Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

‘Click chemistry’ synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase

(2010) Ivone Carvalho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cyclooligomerisation of azido-alkyne-functionalised sugars: synthesis of 1,6-linked cyclic pseudo-galactooligosaccharides and assessment of their sialylation by Trypanosoma cruzi trans-sialidase

(2010) Vanessa L. Campo et al.   Chemical Science

Chemistry and Biology of Galactofuranose-Containing Polysaccharides

(2009) Michele R. Richards et al.   CHEMBIOCHEM

Development of New and SelectiveTrypanosoma cruzitrans-Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives

(2009) Jin Hyo Kim  et al.   CHEMBIOCHEM

Potent Fluoro-oligosaccharide Probes of Adhesion inToxoplasmosis

(2009) Sarah A. Allman et al.   CHEMBIOCHEM

Approaches for the Development of New Anti-Trypanosoma cruzi Agents

(2009) Diogo Rodrigo Magalhaes Moreira et al.   CURRENT DRUG TARGETS

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) ofToxoplasma gondii

(2009) James A. Garnett et al.   PROTEIN SCIENCE

A New Generation of SpecificTrypanosoma cruzi trans-Sialidase Inhibitors

(2008) Sabrina Buchini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic and Mechanistic Analysis ofTrypanosoma cruziTrans-Sialidase Reveals a Classical Ping-Pong Mechanism with Acid/Base Catalysis†

(2008) Iben Damager et al.   BIOCHEMISTRY

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

(2008) João Neres et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural insights into sialic acid enzymology

(2008) Alejandro Buschiazzo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Disease-associated carbohydrate-recognising proteins and structure-based inhibitor design

(2008) Mark von Itzstein   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chemical Structure of Major Glycoconjugates from Parasites

(2008) Lucia Mendonca-Previato et al.   CURRENT ORGANIC CHEMISTRY

Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease

(2008) J NERES et al.   DRUG DISCOVERY TODAY

Sialoglycotherapeutics in Protozoal Diseases

(2008) Angana Ghoshal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY