Article
Multidisciplinary Sciences
Irinela Chilibon, Adina-Maria Paun, Cristina Vasiliu, Elena Diacu, Raluca Isopescu, Eleonora-Mihaela Ungureanu
Summary: Sensitive electrodes based on complexing azulene polymer films were prepared using electrochemical deposition. The films were characterized using various methods and it was found that the complexing units were preserved in the films.
Article
Biochemistry & Molecular Biology
Hongfei Wu, Xingxing Lu, Jingbo Xu, Xiaoming Zhang, Zhinian Li, Xinling Yang, Yun Ling
Summary: A series of new N-(thiophen-2-yl) nicotinamide derivatives were designed and synthesized based on the modification of natural products and the active substructure splicing method. Among them, compounds 4a and 4f showed excellent fungicidal activities and had higher control efficacies compared to commercial fungicides. These derivatives are significant lead compounds, and compound 4f is a promising fungicide candidate.
Article
Polymer Science
Anamika Mishra, Sonal Gupta, Asit Patra
Summary: The facile and efficient synthesis of conjugated donor-acceptor polymers via direct C-H arylation polymerization has received significant interest in the field of organic electronics. In this study, a one-pot synthesis method was used to successfully synthesize a series of bis(thiophen-2-yl)benzothiadiazole-based donor-acceptor polymers. The resulting polymers exhibited excellent solubility and were characterized for their optical and electrochemical properties. Additionally, the polymer films blended with PC71BM showed temperature-dependent absorption for potential photovoltaic applications, with a power conversion efficiency of 3.82%.
Article
Chemistry, Physical
Sunil L. Dhonnar, Vishnu A. Adole, Rahul A. More, Nutan V. Sadgir, Bapu S. Jagdale, Thansing B. Pawar, Mohamed I. Elzagheid, Lydia Rhyman, Ponnadurai Ramasami
Summary: This study synthesized and analyzed two novel oxadiazole derivatives using experimental and computational methods, and investigated their spectra, structural parameters, charge transfer, and reactivity. The experimental results showed that these compounds exhibited moderate antibacterial and antifungal activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Sebastian Lijewski, Jiri Tydlitat, Beata Czarczynska-Goslinska, Milan Klikar, Jadwiga Mielcarek, Tomasz Goslinski, Lukasz Sobotta
Summary: In this study, a new tetrapyrazinoporphyrazine derivative with peripheral menthol-thiophenyl substituents was successfully synthesized and purified with a 36% yield. Characterization of the derivative was done using UV-Vis, NMR, and MS spectroscopy, with further analysis of its structure through complex NMR studies. The new tetrapyrazinoporphyrazine exhibited low singlet oxygen generation, but showed high stability under visible light irradiation.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Physical
Manish Rana, Aysha Fatima, Nazia Siddiqui, Sajad Hussain Dar, Saleem Javed, Rahisuddin
Summary: Compound 3c was synthesized and characterized, showing strong antioxidant activity and intercalative mode of interaction with DNA. The study provided a comprehensive analysis of its molecular structure and properties using experimental and computational methods.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Mirna T. Helmy, Farid M. Sroor, Karima F. Mahrous, Khaled Mahmoud, Hamdi M. Hassaneen, Fatma M. Saleh, Ismail A. Abdelhamid, Mohamed A. Mohamed Teleb
Summary: Twelve novel chalcone derivatives were synthesized using the Claisen-Schmidt condensation reaction, and compound 7g showed the most promising anticancer activity among them.
ARCHIV DER PHARMAZIE
(2022)
Article
Pharmacology & Pharmacy
Y. -C. Liu, J. Luo, S. -Y. Wang, Z. -X. Liang, X. Zhang, B. -D. Wang, Y. -Y. LI, R. -X. Lei, J. -Y. Wang, G. -P. Zhao, C. -X. Bai, H. Chen
Summary: This study aimed to investigate the CT-DNA binding properties and HeLa cell viabilities of metal complexes derived from H2L1 and HL2. A series of metal complexes derived from H2L1 and HL2 were synthesized, and their structures were characterized. Both ligands and their metal complexes can bind strongly to CT-DNA through hydrogen bond and intercalation, and the groove pattern cannot be excluded. The presence of [Ni(HL1)(2)] and [Cu(HL1)(2)] showed lower viabilities in HeLa cells, indicating their potential as anti-tumor drugs.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Sukriye Cakmak, Sevgi Kansiz, Mohammad Azam, Cem Cuneyt Ersanli, Onder Idil, Aysel Veyisoglu, Hasan Yakan, Halil Kutuk, Arunabhiram Chutia
Summary: A novel heterocyclic amide derivative was synthesized and investigated for its significant antioxidant and antimicrobial properties through experimental and computational studies.
Article
Chemistry, Inorganic & Nuclear
Marjaana Taimisto, Merja J. Poropudas, J. Mikko Rautiainen, Raija Oilunkaniemi, Risto S. Laitinen
Summary: The reaction between [RuCl2(CO)(3)](2) and Te(2)Tpn(2) (Tpn=thiophen-2-yl, C4H3S) in the absence of light resulted in the formation of cct-[RuCl2(CO)(2)(TeTpn(2))(2)] (1) [cis(Cl)-cis(CO)-trans(TeTpn(2))] and TeTpn(2) (2), along with the precipitation of tellurium. Both complex 1 and monotelluride 2 were characterized using NMR spectroscopy and single-crystal X-ray diffraction. The decomposition of Te(2)Tpn(2) to TeTpn(2) was found to be faster than the ligand substitution in [RuCl2(CO)(3)](2) by TeTpn(2) based on Te-125 NMR spectroscopy.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gulraiz Ahmad, Nasir Rasool, Adeel Mubarik, Ameer Fawad Zahoor, Muhammad Ali Hashmi, Muhammad Zubair, Muhammad Bilal, Mohamed Hussien, Muhammad Saeed Akhtar, Sajjad Haider
Summary: A series of pyrazine analogs were synthesized by a Suzuki cross-coupling reaction in this study. The impact of various substituents on the properties of the molecules was investigated, and the structures and properties of the compounds were analyzed through DFT calculations and experimental comparisons.
Article
Chemistry, Medicinal
Liyu Zhao, Yin Sun, Wenbo Yin, Linfeng Tian, Nannan Sun, Yang Zheng, Chu Zhang, Shizhen Zhao, Xin Su, Dongmei Zhao, Maosheng Cheng
Summary: A series of novel derivatives were designed and synthesized, and compounds A30-A34 exhibited excellent broad-spectrum antifungal activity with low minimum inhibitory concentrations against various fungi. Compounds A31 and A33 showed high metabolic stability in vitro and weak inhibitory effects on liver microsomal enzymes. Compound A31 demonstrated favorable pharmacokinetic properties in SD rats.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Optics
Soyeon Kim, Nam Gi Cho, Namwook Kim, Gi-Chung Kwon, Jun-Gill Kang, Youngku Sohn, In Tae Kim
Summary: Introducing different substituents to the thiophenyl moiety of 2-hydroxy-4-benzoate can modulate its luminescence properties, with methoxy group significantly enhancing the quantum yield and cyano group slightly enhancing it; MHncTB also exhibits orange emission in specific solvents, attributed to the excited state proton transfer from the solute to the solvent.
JOURNAL OF LUMINESCENCE
(2021)
Article
Chemistry, Organic
Nur Hidayah Azeman, Muhammad Asif Ahmad Khushaini, Rusli Daik, Ahmad Ghadafi Ismail, Burhanuddin Yeop Majlis, Muhammad Mat Salleh, Tg Hasnan Tg Abdul Aziz, Ahmad Ashrif A. Bakar, Ahmad Rifqi Md Zain, Chin-Hoong Teh
Summary: In this study, a novel material BOBzBT(2) with an extended pi-conjugation backbone was synthesized through functionalization and the addition of benzo[b]thiophene rings to improve solubility and promote cation radicals' formation. The disappearance of the stretching peak in FTIR confirmed the coupling of benzo[b]thiophene rings, and UV-visible analysis showed transitions related to the pi-pi* interactions between thiophene and bithiophene groups. The compound BOBzBT(2) exhibited high purity in DSC analysis, and showed interactions with creatinine through NH-S and NH-O hydrogen bonding.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Isabella Romeo, Antonella Brizzi, Federica Pessina, Francesca Alessandra Ambrosio, Francesca Aiello, Carmela Belardo, Gabriele Carullo, Giosue Costa, Luciano De Petrocellis, Maria Frosini, Livio Luongo, Samuele Maramai, Marco Paolino, Aniello Schiano Moriello, Claudia Mugnaini, Francesco Scorzelli, Sabatino Maione, Federico Corelli, Vincenzo Di Marzo, Stefano Alcaro, Anna Artese
Summary: We developed a rational drug design strategy and synthesized ligands to improve the binding properties and potency of a previously identified TRPV1 agonist. Molecular modeling and simulations guided the design towards introducing a lipophilic iodine and a flat pyridine/benzene at a specific position in the ligand. Most synthesized compounds showed high TRPV1 efficacy, selectivity, and protective properties against oxidative stress-induced ROS formation. The compounds also exhibited neuroprotective and antinociceptive effects in biological evaluations.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Alessio Cesaretti, Carmela Bonaccorso, Veronica Carboni, Maria Sole Giubila, Cosimo Gianluca Fortuna, Fausto Elisei, Anna Spalletti
Article
Chemistry, Multidisciplinary
Chiara M. A. Gangemi, Rosalba Randazzo, Masimiliano Gaeta, Cosimo G. Fortuna, Maria E. Fragala, Roberto Purrello, Alessandro D'Urso
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2020)
Article
Chemistry, Multidisciplinary
Carmela Bonaccorso, Irina Naletova, Cristina Satriano, Giorgia Spampinato, Vincenza Barresi, Cosimo G. Fortuna
Article
Chemistry, Physical
Alessio Cesaretti, Paolo Foggi, Cosimo G. Fortuna, Fausto Elisei, Anna Spalletti, Benedetta Carlotti
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Medicinal
Maria Grazia Perrone, Morena Miciaccia, Paola Vitale, Savina Ferorelli, Cristina da Costa Bernardes Araujo, Gabriella Silva de Almeida, Thaisa Francielle Souza Domingos, Luiz Claudio Rodrigues Pereira da Silva, Marcelo de Padula, Lucio Mendes Cabral, Plinio Cunha Sathler, Carmela Bonaccorso, Cosimo G. Fortuna, Antonio Scilimati
Summary: Cardiovascular diseases (CVDs) lead to over 17 million deaths globally each year, with arterial thrombosis being a significant contributor. Platelets play a crucial role in the pathogenesis of these diseases, and modulating their activity is an effective treatment strategy for thrombotic events. Research on inhibitors targeting COX-1 and COX-2 activity show potential for selective inhibition and new therapeutic approaches for cardiovascular diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Gabriele Valora, Carmela Bonaccorso, Alessio Cesaretti, Cosimo G. Fortuna, Anna Spalletti, Fausto Elisei
Summary: This study thoroughly investigated the interactions between a series of sterically hindered phenanthroline derivatives and first-row transition metal ions through a combined spectroscopic study. The research found that the fluorescence emission quenching of these compounds is highly sensitive to the presence of cations, which can be utilized for analytical purposes. Additionally, femtosecond transient absorption measurements revealed unique excite state dynamics depending on the charge density of the metal ions considered.
Article
Infectious Diseases
Dafne Bongiorno, Nicolo Musso, Paolo G. Bonacci, Dalida A. Bivona, Mariacristina Massimino, Stefano Stracquadanio, Carmela Bonaccorso, Cosimo G. Fortuna, Stefania Stefani
Summary: The research team focused on synthesizing novel antibiotics - synthetic heteroaromatic stilbene derivatives, which have a broad spectrum of antibacterial activity. Experimental validation showed excellent bacteriostatic activity, paving the way for the development of new antibiotics.
Article
Chemistry, Applied
Letizia Mencaroni, Carmela Bonaccorso, Valentina Botti, Benedetta Carlotti, Giuseppe Consiglio, Fausto Elisei, Cosimo G. Fortuna, Anna Spalletti, Alessio Cesaretti
Summary: Six water-soluble bications with a symmetric A+-pi-D-pi-A+ structure were synthesized and studied for their absorption, fluorescence properties, and nonlinear optical response. The molecules exhibited a panchromatic family of dyes covering the entire visible spectrum and displayed ultrafast intramolecular charge transfer processes. These compounds, with significant fluorescence capability and good water solubility, show potential for bioimaging applications.
Article
Biochemistry & Molecular Biology
Alessio Cesaretti, Eleonora Calzoni, Nicolo Montegiove, Tommaso Bianconi, Martina Alebardi, Maria Antonietta La Serra, Giuseppe Consiglio, Cosimo Gianluca Fortuna, Fausto Elisei, Anna Spalletti
Summary: Fluorescence imaging is seeking new far-red emitting probes that selectively respond to specific biological targets. Cationic push-pull dyes, with their intramolecular charge transfer (ICT) character and strong interaction with nucleic acids, show promise in meeting these requirements. In this study, two isomers of push-pull dimethylamino-phenyl dyes were examined for their ICT dynamics, DNA/RNA affinity, and in vitro behavior. The para-quinolinium derivative exhibited RNA-selectivity, localizing in nucleoli and mitochondria with fluorescence microscopy. It also showed potential as a theranostic agent with improved turn-on response and localized staining ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Federica Sipala, Gianfranco Cavallaro, Giuseppe Forte, Cristina Satriano, Alessandro Giuffrida, Aurore Fraix, Angelo Spadaro, Salvatore Petralia, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Simone Ronsisvalle
Summary: In recent years, the study of SARS-CoV-2 spike protein and its mutations has become crucial in understanding its interaction with human host receptors. Through in silico studies, it has been found that heterocyclic compounds with different chemical characteristics may interact with the spike protein and disrupt the interaction between ACE2 and the spike protein. Although further research is needed, this study suggests that these heterocyclic push-pull compounds could potentially inhibit spike protein-ACE2 binding.
Article
Fisheries
Martina Contino, Greta Ferruggia, Roberta Pecoraro, Elena Maria Scalisi, Gianfranco Cavallaro, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Antonio Salvaggio, Fabiano Capparrucci, Teresa Bottari, Maria Violetta Brundo
Summary: Polystyrene (PS) is a widely used plastic polymer, mainly for disposable products. Due to its resistance to degradation, PS can remain in the environment for a long time. This study found that nanoplastics made of amino-modified polystyrene (nPS-NH2) could bioaccumulate in the head, especially in the eyes, after being internalized. Moreover, their interaction with receptors could lead to oxidative stress and apoptosis in the bioaccumulated regions. This study confirms the danger of nanoplastic wastes released into the environment.
Article
Chemistry, Physical
Alessio Cesaretti, Anna Spalletti, Fausto Elisei, Paolo Foggi, Raimondo Germani, Cosimo G. Fortuna, Benedetta Carlotti
Summary: This study investigated the excited-state dynamics and nonlinear optical properties of two symmetrical quadrupolar cationic push-pull compounds with different lateral electron donors, as well as their dipolar counterparts. The research found that excited-state symmetry breaking in the quadrupolar compounds significantly affects their nonlinear optical properties and two-photon absorption ability.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Valentina Botti, Lorena Urbanelli, Krizia Sagini, Luigi Tarpani, Alessio Cesaretti, Cosimo G. Fortuna, Fausto Elisei
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2020)
Review
Chemistry, Medicinal
Carmela Bonaccorso, Tiziano Marzo, Diego La Mendola
Article
Chemistry, Organic
Jimi M. Alex, Giovanna Brancatelli, Stefano Volpi, Carmela Bonaccorso, Alessandro Casnati, Silvan Geremia, Peter B. Crowley
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
