Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 6, Pages 1723-1726Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01045f
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Funding
- NSFC [20872032, 20972044]
- NCET [08-0175]
- Chinese Ministry of Education [108167]
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A novel strategy to systematically tune the pK(a) values of rhodamines is described. This strategy was applied to rationally develop compound 1e with a pK(a) of 6.5, the highest among rhodamine amide derivatives, and it could be employed to detect acidic pH variations in living cells with a turn-on signal.
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