Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 11, Pages 4250-4255Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05116d
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Funding
- National Natural Science Foundation of China [30960460, 20925205, 20832005]
- National Basic Research Program of China (973 Program) [2009CB522300]
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A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.
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