Article
Biochemistry & Molecular Biology
Svetlana S. Efimova, Olga S. Ostroumova
Summary: This study systematically analyzed the molecular mechanisms of action of saponins and related compounds on model lipid membranes, demonstrating their effects on membrane hydration layer restructuring, membrane dipole potential alteration, lipid melting and disordering, and lipid packing modifications. It was also found that the ability of saponins to disengage markers from lipid vesicles might be determined by their ability to induce positive curvature stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Miriam Hernandez-Morales, Victor Han, Richard H. Kramer, Chunlei Liu
Summary: FeRIC is a magnetogenetic technique using RF alternating magnetic fields to activate TRPV channels and increase cytosolic Ca2+ levels. The interaction between RF and ferritin increases free cytosolic iron levels, triggering the activation of specific pathological channels.
Article
Biochemistry & Molecular Biology
Dayana N. Chernyshova, Alexander A. Tyulin, Olga S. Ostroumova, Svetlana S. Efimova
Summary: This study focused on the action of lantibiotic nisin on phospholipid membranes, revealing that its effectiveness depends on the membrane composition and can exert its anti-tumor activity by forming ion pores. The preferential interaction of nisin with cardiolipin-enriched bilayers was observed, and small molecules were found to enhance the membrane activity of nisin.
Article
Chemistry, Multidisciplinary
Dan Qiao, Himanshu Joshi, Huangtianzhi Zhu, Fushi Wang, Yang Xu, Jia Gao, Feihe Huang, Aleksei Aksimentiev, Jiandong Feng
Summary: Synthetic nanopores have been developed for applications in membrane filtration technologies and biomolecular sensing, but challenges remain in providing them with atomically defined shape and deliberate placement of chemical groups. A chemically defined transmembrane nanopore, EPM, demonstrates stable transmembrane transport functionality, particularly with up to 21-fold selectivity for potassium over sodium ions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Tingting Zhao, Nicola L. Bell, Greig Chisholm, Balamurugan Kandasamy, De-Liang Long, Leroy Cronin
Summary: In order to meet the increasing energy density demands of battery technology, the development of electrolytes with high electron storage capacity is crucial. Polyoxometalate (POM) clusters have the potential to act as electron storage electrolytes for flow batteries. However, little is known about the factors influencing the storage ability of these clusters, hindering their rational design. This study investigates large POM clusters and identifies key structural and speciation factors influencing their improved storage ability over previously reported clusters.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Cedric Vallee, Brendan Howlin, Rebecca Lewis
Summary: The Epithelial Sodium Channel/Degenerin (ENaC/DEG) family is a superfamily of sodium-selective channels with high homology in the pore region, playing important physiological roles in various animal species. The G/SxS selectivity filter and other conserved residues are crucial for ion selectivity, with different residues involved in ion permeability depending on the ion type. This review highlights new perspectives for further exploration of ion selectivity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Anastasiia A. Zakharova, Svetlana S. Efimova, Olga S. Ostroumova
Summary: This study investigated the ability of polymyxin B to form ion pores in model membranes, revealing that the antibiotic predominantly interacts with negatively charged lipids. The pore-forming ability of polymyxin B depends on the shape of membrane lipids and could be utilized to develop innovative lipopeptide-based formulations.
Article
Multidisciplinary Sciences
Chuandi Yu, Wen Ding, Lei Zhu, Yuhang Zhou, Yingkui Dong, Ling Li, Juanjuan Liu, Yizhuo Wang, Zehua Li, Lina Zhu, FaJun Chen, Maosen Ruan, Dongming Qian, Yujuan Wang, Bo Wu, Huangtao Xu, Ming Li, Yunchen Bi, Hao Wang, Weiqian Wang, Peng Chao, Lei Xing, Bing Shen, Han Dai, Lisha Zha, Hongxin Zhao, Junfeng Wang
Summary: By incorporating M2(1-46) protein into nanodiscs, researchers generated vNARs that specifically bind to tetrameric M2 proteins and can block ion influx through M2 channels. This study provides a new approach for developing influenza vaccines by targeting the M2 protein.
Article
Biophysics
Themis Lazaridis
Summary: The M2 proton channel in influenza A virus allows acidification of the virion when external pH is lowered, but does not conduct protons outward when internal pH is lowered. Trp41 and Asp44 residues play a role in preventing pH-driven outward conductance, but the mechanism is unclear. Molecular dynamics simulations reveal that inward proton movement is easier than outward movement when key His37 residues are neutral, and this preference for inward movement increases with increasing charge on His37. Several factors contribute to this asymmetry, including electrostatic interactions, orientation of hydronium ions, and trapping of ions at specific sites in the channel.
BIOPHYSICAL JOURNAL
(2023)
Article
Chemistry, Physical
Yuxin Tong, Ang Gao, Qinghua Zhang, Tao Gao, Jinming Yue, Fanqi Meng, Yue Gong, Shibo Xi, Zejing Lin, Minglei Mao, Siyuan Peng, Xuefeng Wang, Dongdong Xiao, Dong Su, Yanhong Luo, Hong Li, Liquan Chen, Liumin Suo, Lin Gu
Summary: The study demonstrates how cation-synergy stabilization can enable anion redox of Chevrel phase Mo6S8 in aluminum ion batteries, with atomic-resolved imaging revealing the crucial role of Mo-Mo bond contraction and elongation in maintaining structural stability.
ENERGY STORAGE MATERIALS
(2021)
Article
Chemistry, Physical
Ke Zhou, Yining Li, Shiyao Zheng, Maojie Zhang, Chunyang Zhang, Corsin Battaglia, Haodong Liu, Kuan Wang, Pengfei Yan, Jianjun Liu, Yong Yang
Summary: The study reveals that increasing the manganese content can reduce irreversible oxygen loss in DRXs, enhancing cycling stability.
ENERGY STORAGE MATERIALS
(2021)
Review
Plant Sciences
Stephen D. Tyerman, Samantha A. McGaughey, Jiaen Qiu, Andrea J. Yool, Caitlin S. Byrt
Summary: Aquaporins have various functions in plants, including as water and neutral solute channels, signaling hubs, and disease virulence factors. They show differences compared to animal aquaporins in terms of ion transportation, potentially playing important roles in different membranes. The permeability of aquaporins can span a wide range, requiring tight regulation through protein interactions and posttranslational modifications.
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021
(2021)
Article
Chemistry, Multidisciplinary
Boya Sun, Qiongqiong Lu, Kaixuan Chen, Wenhao Zheng, Zhongquan Liao, Nikolaj Lopatik, Dongqi Li, Martin Hantusch, Shengqiang Zhou, Hai Wang, Zdenek Sofer, Eike Brunner, Ehrenfried Zschech, Mischa Bonn, Richard Dronskowski, Daria Mikhailova, Qinglei Liu, Di Zhang, Minghao Yu, Xinliang Feng
Summary: This study reports on the construction of redox-active phosphorus-oxygen terminals as an attractive strategy to significantly enhance the specific capacities of Nb4C3 MXenes for ultrafast Na+ storage. The molecular-level design of MXene terminals provides opportunities for developing high-capacity and fast-charging electrodes, alleviating the energy-power tradeoff typical for energy-storage devices.
ADVANCED MATERIALS
(2022)
Article
Engineering, Chemical
Yun Jin, Yiyi Fan, Xiuxia Meng, Jinyong Li, Claudia Li, Jaka Sunarso, Naitao Yang, Bo Meng, Weimin Zhang
Summary: In this study, a one-dimensional model was used to investigate the transport of hydrated cations through 2D MXene membranes, with parameters regressed using experimental data to show significant influences of external electric field and transmembrane pressure on permeation flux.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Biophysics
Yiqing Wang, Jinwei Zhang, Haiping Gao, Yuan Sun, Lei Wang
Summary: This paper summarized the fabrication approaches and application progress of lipid nanotubes (LNTs), and discussed the potential significance for their future development.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Shaodong Zhang, Hao-Jan Sun, Andrew D. Hughes, Bogdan Draghici, Janis Lejnieks, Pawaret Leowanawat, Annabelle Bertin, Lidiannie Otero De Leon, Oleg V. Kulikov, Yingchao Chen, Darrin J. Pochan, Paul A. Heiney, Virgil Percec
Article
Chemistry, Multidisciplinary
Bogdan Draghici, Daniela Vullo, Suleyman Akocak, Ellen A. Walker, Claudiu T. Supuran, Marc A. Ilies
CHEMICAL COMMUNICATIONS
(2014)
Article
Chemistry, Organic
Alan R. Katritzky, Bahaa El-Dien M. El-Gendy, Bogdan Draghici, C. Dennis Hall, Peter J. Steel
JOURNAL OF ORGANIC CHEMISTRY
(2010)
Article
Chemistry, Organic
Bogdan Draghici, Bahaa El-Dien M. El-Gendy, Alan R. Katritzky
SYNTHESIS-STUTTGART
(2012)
Article
Chemistry, Multidisciplinary
Bogdan Draghici, Finn K. Hansen, Ana-Maria Buciumas, Bahaa El-Dien M. El-Gendy, Ekaterina Todadze, Alan R. Katritzky
Meeting Abstract
Biochemistry & Molecular Biology
Rajesh Kishore Kumar Sanku, Nicole Lemon, Matthew Salkovitz, Bogdan Draghici, Marc A. Ilies, Ellen A. Walker
Meeting Abstract
Biochemistry & Molecular Biology
Taylor Alexis Spoon, Rajesh Kishore Kumar Sanku, Bogdan Draghici, Marc A. Ilies, Ellen Walker
Meeting Abstract
Biochemistry & Molecular Biology
Rajesh Kishore Kumar Sanku, Bogdan Draghici, Yang Pan, Marc Ilies, Ellen Walker
Article
Nanoscience & Nanotechnology
Uttam Satyal, Bogdan Draghici, Lisa L. Dragic, Qiangnan Zhang, Kyle W. Norris, Muniswamy Madesh, Eugen Brailoiu, Marc A. Ilies
ACS APPLIED MATERIALS & INTERFACES
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Uttam Satyal, Bogdan Draghici, Tiffany Sommers, Qiangnan Zhang, Marc Ilies
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Utpal Mondal, Bogdan Draghici, Joseph Musco, Marc Ilies
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Marc Ilies, Rajesh Sanku, Bogdan Draghici, Utpal Mondal, Ellen Walker, Claudiu Supuran
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Joseph Musco, Bogdan Draghici, Utpal Mondal, Marc Ilies
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Bogdan Draghici, Bahaa El-Dien M. El-Gendy
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Meeting Abstract
Chemistry, Multidisciplinary
Bahaa El-Dien M. El-Gendy, Alan R. Katritzky, C. Dennis Hall, Bogdan Draghici
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2010)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)