Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 7, Issue 13, Pages 2761-2769Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b901631g
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- PRESTO of JST (Japan Science and Technology)
- JSPS (Japan Society for the Promotion of Science)
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This paper describes the synthesis and properties of a novel molecular beacon (MB) containing a benzene-phosphate backbone at its stem moiety. The fluorescence intensity of MBs was found to stabilize by the introduction of the benzene-phosphate backbone at its stem moiety. Furthermore, an MB containing the benzene-phosphate backbone was more resistant to DNase I (endonuclease) than an MB comprising natural DNA and 2'-O-methyl-RNA. These results indicate that the MB with the benzene-phosphate backbone is superior as a molecular beacon as compared to the MB composed of natural DNA and 2'-O-methyl-RNA.
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