Article
Chemistry, Analytical
Keith Smith, Xiaojing Mu, Zhaoqiang Li, J. Stuart Woodhead, Gamal A. El-Hiti
Summary: Two new acridinium triflates with a 2-(succinimidyloxycarbonyl)ethyl side arm have been synthesized and characterized. The chemiluminescence properties and hydrolytic stabilities of the newly synthesized acridinium triflates were investigated.
Article
Chemistry, Analytical
Keith Smith, Xiaojing Mu, Zhaoqiang Li, J. Stuart Woodhead, Gamal A. El-Hiti
Summary: Several novel N-substituted acridinium esters have been synthesized and their chemiluminescent properties have been tested. The characteristics of the substituent on the nitrogen atom were found to affect their chemiluminescent efficiency and hydrolytic stability. Additionally, dibromo-substituted leaving groups slightly accelerated the chemiluminescence process.
Article
Chemistry, Analytical
Keith Smith, Xiaojing Mu, Zhaoqiang Li, Andy M. Holland, J. Stuart Woodhead, Gamal A. El-Hiti
Summary: Several new acridinium esters 2-9 with different substituents on their central acridinium ring have been synthesized and tested for their chemiluminescent properties. The esters with 2,5-dimethylphenyl emit light slowly, while the esters with 2,6-dinitrophenyl and 2,6-bis(trifluoromethyl)phenyl emit light rapidly. The hydrolytic stabilities of the compounds are influenced by the substituent at the 10 position.
Article
Nanoscience & Nanotechnology
Hui Ouyang, Jiaxin Xian, Shuai Luo, Lvxia Zhang, Wenwen Wang, Zhifeng Fu
Summary: A facile one-step doping method was used to synthesize Co single atomic site catalysts in UiO-66 metal-organic frameworks, leading to a significant enhancement in chemiluminescent emission. MXenes were shown to efficiently quench the emission signal of Co SASCs. The combination of Co SASCs and titanium carbide MXenes was successfully applied to develop an immunoassay method for detecting cardiac troponin I.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Manabu Nakazono, Kenji Hamase
Summary: Four novel bis-acridinium esters were synthesized and their chemiluminescence properties were studied. The introduction of fluorine and methyl groups at specific positions greatly affected the chemiluminescence intensities. One of the esters showed strong and long-lasting chemiluminescence under neutral and alkaline conditions and was used for sensitive determination of hydrogen peroxide and catalase activity. The linear calibration ranges for hydrogen peroxide and catalase activity were 5-1000 μM and 0.05-1 U/mL, respectively.
Article
Chemistry, Physical
Cheng-Long Shen, Jin-Hao Zang, Qing Lou, Guang-Song Zheng, Meng-Yuan Wu, Yang-Li Ye, Jin-Yang Zhu, Kai-Kai Liu, Lin Dong, Chong-Xin Shan
Summary: Surface chemical regulation strategy can enhance the chemiluminescence (CL) performance of carbon nanodots (CDs), with optimized CD showing higher brightness and quantum yield compared to the initial CDs. This improvement is attributed to the decreased electron capture from water molecules generated during the CL process.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Hui Ouyang, Hongwei Yuan, Junyi Huang, Jiaxin Xian, Wenwen Wang, Zhifeng Fu
Summary: Single-atom site catalysts with optimal catalytic efficiency are widely used in various fields. However, the low loading ratio of active sites hampers their catalytic activity improvement. Here, a low-temperature reduction method was employed to synthesize CoN4-supported Co2N clusters, which exhibited superior chemiluminescent catalytic capacity compared to pure single-atom site catalysts.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Applied
Keith Smith, Zabair Ahmed, J. Stuart Woodhead, Gamal A. El-Hiti
Summary: Novel acridinium esters with multiple methyl substituents, including one in the 1 or 8-position, have been synthesized and characterized. The influence of methyl substituents on the chemiluminescent properties of the esters has been investigated.
JOURNAL OF OLEO SCIENCE
(2023)
Article
Chemistry, Applied
Manabu Nakazono, Shinkoh Nanbu, Takeyuki Akita, Kenji Hamase
Summary: The introduction of methyl groups in acridinium esters can shift the optimal pH for relatively strong chemiluminescence from neutral to alkaline conditions. Certain compounds exhibit long-lasting chemiluminescence under alkaline conditions, which could be used for detecting hydrogen peroxide concentration.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Yuguang Jing, Xiaohua Yuan, Yingying Xu, Jingyu Hou, Xinge Yu, Bangce Ye, Yingchun Li
Summary: A novel chemiluminescence hydrogel is developed for rapid color visualization of sarcosine in urine, which can be used for information encryption and protection. Four different colors of chemiluminescence hydrogels are prepared by adding different ratios of rhodamine B or fluorescein. In the multicolor hydrogels, activated chemiluminescence can generate conventional multicolor code shift and original white light. The luminescence duration and cause of white light are analyzed using chemiluminescence spectroscopy. Sarcosine oxidase is replaced with sarcosine in the multicolor hydrogels to obtain the translation of editable code, facilitating secondary information encryption and code transmissions. The effective luminescence time of these hydrogels is short (13-50 min), and the code can be naturally deleted.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Analytical
Ming Lei, Yahui Zhang, Yongjie Hu, Yongping Dong, Wangbing Zhang
Summary: Spinel-type CuGa2O4 nanoparticles were combined with MoS2 nanosheets to create a uniform CuGa2O4/MoS2 nanocomposite that could be used as an efficient electrochemical platform. The strong anodic electrogenerated chemiluminescence (ECL) of Ru(bpy)32+ at the MoS2 modified electrode was inhibited in the presence of CuGa2O4 nanoparticles due to resonance energy transfer (RET) between Ru(bpy)32+ ECL and CuGa2O4/MoS2 nanocomposite. The peroxide oxidase-like properties of CuGa2O4 nanoparticles allowed it to interact with cholesterol and cut off the RET pathway, leading to the recovery of ECL signal. The modified electrode showed excellent repeatability, reproducibility, and long-term stability for cholesterol detection in serum samples, demonstrating the potential of spinel-type metal oxide combined with 2D materials in ECL biosensors.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Dongni Han, Danjun Fang, Giovanni Valenti, Francesco Paolucci, Frederic Kanoufi, Dechen Jiang, Neso Sojic
Summary: Electrochemiluminescence (ECL) is an electrochemical technique that offers an optical readout and has recently evolved into a powerful microscopy technique. This study reveals the reaction kinetics of ECL through dynamic imaging, providing a new method for exploring the dynamics and mechanisms of ECL in bioassays and cell microscopy.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jaeyoon Kim, Kyunglim Pyo, Dongil Lee, Won-Yong Lee
Summary: This study characterized the ECL behavior of atomically precise Au-22(SG)(18) NCs in aqueous solution and found that their ECL intensity was significantly higher than that of commonly used Au@BSA NCs, showing sensitivity to the concentrations of Au-22(SG)(18) NCs and TPA.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Anchen Fu, Yanjia Mao, Hongbo Wang, Zhijuan Cao
Summary: Optical analysis, including fluorescent, bioluminescent, and chemiluminescent methods, is a non-destructive and real-time technology with specific spatial resolution that has been developed for studying diseases. The chemiluminescent (CL) probes with an adamantane-dioxetane chemiluminescence (AD-CL) scaffold have attracted much attention due to their elimination of external light source, low phototoxicity, high sensitivity, and facile system without additional reagents. Recent research progress on AD-CL probes, including their molecular modification strategy and applications in various cases, has been reviewed.
PROGRESS IN CHEMISTRY
(2023)
Article
Chemistry, Analytical
Koji Karasawa, Hidetoshi Arakawa
Summary: This article introduces a miRNA analysis system that combines nucleic acid sequence-based amplification (NASBA) and chemiluminescence methods, which can be used for point-of-care testing. This method is compact, simple, rapid, and highly sensitive, and it is of great significance for the development of future point-of-care testing systems.
Article
Chemistry, Multidisciplinary
Keith Smith, Amany S. Hegazy, Gamal A. El-Hiti
JOURNAL OF SULFUR CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Keith Smith, Amany S. Hegazy, Gamal A. El-Hiti
JOURNAL OF SULFUR CHEMISTRY
(2020)
Article
Materials Science, Composites
Yuan Xin, Fangli Duan, Xiaojing Mu
POLYMER COMPOSITES
(2020)
Article
Chemistry, Physical
Wei Gui, Fangli Duan, Xiaojing Mu
APPLIED SURFACE SCIENCE
(2020)
Article
Chemistry, Physical
Keith Smith, Alaa K. H. Al-Khalaf, Kiymet Berkil Akar, Doaa J. K. Al-Badri, Benson M. Kariuki, Gamal A. El-Hiti
Summary: The influence of structured solids on the regioselectivity of the dibromination reaction at room temperature was studied, showing differences in selectivity based on the type of solid used. Practical preparative procedures can be devised based on these observations.
Article
Chemistry, Multidisciplinary
Basil A. Saleh, Keith Smith, Mark C. Elliott, Gamal A. El-Hiti
Summary: In this study, various 2-substituted-1,3-dithiane oxides were metalated and reacted for the first time with a trialkylborane, leading to the migration of functional groups and the formation of novel products. However, the overall yields were low in these reactions.
JOURNAL OF SULFUR CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Yan Gou, Xiaojing Mu, Yan Li, Meiling Tang, Gang Chen, Shangyou Xiao
Summary: The study successfully achieved simultaneous extraction and fractionation of LAB and Tan IIA from Salvia miltiorrhiza Bunge using three-liquid-phase extraction and re-partition as an integrated process.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Xia Wang, Wei Gui, Fangli Duan, Xiaojing Mu
Summary: The study shows that adsorbed functional groups can enhance the interaction strength between graphene oxide and iron oxide substrate, with the magnitude of binding energy enhancement depending on the adsorption sites of functional groups. Models with adjacent C atom to the top oxygen atom on the oxide surface exhibit significantly enhanced binding energy, while other models show slightly increased binding energy.
Article
Engineering, Mechanical
Zhongren Li, Fang Zheng, Lingfei Wang, Fangli Duan, Xiaojing Mu
Summary: The study found that the adsorption of hydrogen atoms during the wear process of graphene can have different influences, leading to the breaking of carbon chains or changes in the propagation direction of wear cavities. Additionally, interfacial C-C bonds tend to form at high-stress positions, further affecting the wear behavior of graphene.
TRIBOLOGY INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Keith Smith, Xiaojing Mu, Zhaoqiang Li, J. Stuart Woodhead, Gamal A. El-Hiti
Summary: Several novel N-substituted acridinium esters have been synthesized and their chemiluminescent properties have been tested. The characteristics of the substituent on the nitrogen atom were found to affect their chemiluminescent efficiency and hydrolytic stability. Additionally, dibromo-substituted leaving groups slightly accelerated the chemiluminescence process.
Article
Chemistry, Multidisciplinary
Haiming Huang, Xiaojing Mu, Jing Deng, Shangyou Xiao, Zhiwei Luo, Gang Chen
Summary: This study aimed to develop a theoretical method for selecting the aqueous two-phase system (ATPS) for paeonol extraction from cortex moutan. The solvation free energies (E-solv) of paeonol were calculated in different ATPS, and their ranking was compared with the extraction yield. The results showed that E-solv ranking was effective in selecting the optimal organic type, organic solvent fraction, and aqueous salt concentration. The use of theoretical E-solv can significantly reduce the tedious experimental work for optimization in ATPS extraction.
Article
Chemistry, Analytical
Keith Smith, Xiaojing Mu, Zhaoqiang Li, Andy M. Holland, J. Stuart Woodhead, Gamal A. El-Hiti
Summary: Several new acridinium esters 2-9 with different substituents on their central acridinium ring have been synthesized and tested for their chemiluminescent properties. The esters with 2,5-dimethylphenyl emit light slowly, while the esters with 2,6-dinitrophenyl and 2,6-bis(trifluoromethyl)phenyl emit light rapidly. The hydrolytic stabilities of the compounds are influenced by the substituent at the 10 position.
Article
Chemistry, Organic
Keith Smith, Alaa K. H. Al-Khalaf, Kiymet Berkil Akar, Benson M. Kariuki, Gamal A. El-Hiti
Summary: The reaction between naphthalene and bromine was investigated, resulting in various brominated products. Crystallization method was employed to obtain high purity products. Additionally, a previously unreported compound, 1,2,4,6-tetrabromonaphthalene, was synthesized and its preparation method was provided.
Article
Chemistry, Organic
Keith Smith, Basil A. Saleh, Mohammed B. Alshammari, Gamal A. El-Hiti, Mark C. Elliott
Summary: Studies have shown that a chiral catalytic system based on a mannitol derivative in the catalytic asymmetric version of the Matteson reaction provides substantial asymmetric induction similar to that achieved with a bis(oxazoline) derivative and ytterbium triflate. Additionally, it was found that fresh ytterbium triflate may reduce the level of asymmetric induction, while aged ytterbium triflate or a fresh sample treated with water can improve the induction effect.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
