☆ 3.8 Article

Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2011)

Journal

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY

Volume 112, Issue 4, Pages 548-554

Publisher

MOSBY-ELSEVIER

DOI: 10.1016/j.tripleo.2011.04.026

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Categories

Dentistry, Oral Surgery & Medicine

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Abstract

Objective. The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. Study design. Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. Results. Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P < .05). Conclusions. This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:548-554)

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