Review
Biochemistry & Molecular Biology
Md Tipu Sultan, Heesun Hong, Ok Joo Lee, Olatunji Ajiteru, Young Jin Lee, Ji Seung Lee, Hanna Lee, Soon Hee Kim, Chan Hum Park
Summary: Hemostasis is crucial in surgical procedures to prevent uncontrolled bleeding. Surgeons need to understand the mechanisms, effectiveness, and adverse effects of different hemostatic agents to make informed choices. Silk fibroin (SF), a natural protein, has been used in textiles and surgical sutures, and has potential applications in biomedical fields. This review discusses the various forms of SF and the latest advancements in SF-based hemostatic agents.
Article
Engineering, Environmental
Yiwen Yang, Shichen Zhang, Xiaoen Bian, Tian Xia, Ang Lu, Lina Zhang, Yanfeng Wang, Bo Duan
Summary: The developed composite hydrogel demonstrated superior mechanical properties, biocompatibility, and biodegradability for preventing bile leakage in hepatobiliary surgery. It showed excellent cytocompatibility in vitro, tunable degradability, and promoted bile duct restoration and re-vascularization in a rabbit biliary duct injury model, providing a new avenue for utilizing natural polymers in the biomedical field.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Physical
Jose Gonzalez-Serrano, Carmen Vallina, Carlos Gonzalez-Serrano, Andres Sanchez-Monescillo, Jesus Torres, Gonzalo Hernandez, Rosa Maria Lopez-Pintor
Summary: The study found that immediate implant procedures (IIP) with platelet concentrates (PCs) had lower marginal bone loss (MBL) at 6 and 12 months follow-ups compared to IIP without PCs. However, there was no reduction in MBL when PCs were used with bone grafts compared to bone grafts alone.
Article
Engineering, Chemical
Xiaoyu Han, Yushi Ke, Ye Wu, Jian Huang, Weilin Xu, Yunli Wang
Summary: In this study, silk fibroin (SF) powder is modified using chitosan and sodium stearate, and is used for oil-water separation. The modified SF powder exhibits better selectivity for oil than the original SF powder and has higher oil-absorption capacity for both soybean oil and engine oil. This work provides a new method and concept for the study of oil-water separation.
Review
Dentistry, Oral Surgery & Medicine
Jeremy Pitman, Lorenz Seyssens, Veronique Christiaens, Jan Cosyn
Summary: This study assessed the effect of immediate provisionalization on soft tissue changes, hard tissue changes, and clinical parameters following single immediate implant placement. The results suggest that immediate provisionalization may contribute to midfacial soft tissue stability at immediate implants.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Medicine, General & Internal
Chun-Yu Han, De-Zhou Wang, Jian-Fei Bai, Lan-Lan Zhao, Wen-Zhi Song
Summary: For cases with keratinized gingiva widths around implants less than 2mm, the soft tissue width and thickness could be increased by modified ARF surgery combined with XCM and PRF. This surgery significantly alleviated patients' pain and improved oral functional comfort.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Chemistry, Physical
Tongyao Lin, Jinglin Zhang, Dongliang Huo, Fengjuan Yang, Jingxian Zhang, Langhuan Huang, Sui-Ping Deng, Shaozao Tan, Huifang Chen
Summary: An intelligent and responsive coating containing silk fibroin and Cu2+ was successfully prepared on titanium to hinder implant-associated infections. The coating released massive Cu2+ to fight against bacteria under slightly acidic conditions, while only releasing a small amount of Cu2+ under physiological conditions to avoid damage to normal cells. In vivo experiments confirmed the antibacterial properties of the coating against S. aureus with negligible toxicity. The design provides support for addressing bacterial infections during the implantation of titanium substrates.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Guanying Gao, Hanmei Dong, Ruiqi Wu, Jianquan Wang, Yingfang Ao, Yan Xu
Summary: This study developed a regenerative implant with osteogenic and chondrogenic effects for the treatment of hip dysplasia. The implant was created by 3D printing polycaprolactone and crosslinked polydopamine mineralization for the osteogenic part, and silk fibroin and bone morphogenetic protein 2 for the chondrogenic part. The implant exhibited good biocompatibility and restored the anatomical morphology of the acetabulum.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Romane Lilet, Martin Desiron, Gary Finelle, Geoffrey Lecloux, Laurence Seidel, France Lambert
Summary: This prospective case series evaluated the outcomes of immediate implants in posterior sites using a custom-made sealing socket abutment and peri-implant socket filling. The study showed a high implant survival rate of 95%, limited hard and soft tissue dimensional changes, and a shortened treatment time.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Endocrinology & Metabolism
A. Scarano, F. Inchingolo, S. Scogna, L. Leo, A. Greco Lucchina, L. Mavriqi
Summary: Cement-retained restorations on implants offer better passive fit and aesthetics, but excess cement can lead to biological complications such as peri-implant tissue inflammation and periimplantitis. Careful cementation methods and materials can help prevent these cement-related peri-implant diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jiabi Xiong, Wei Sun, Bin Huang, Wei Ji, Bin Shi
Summary: This study aimed to evaluate the effect of ISPRs on the accuracy of intraoral scanned peri-implant soft-tissue profile. The results showed that ISPRs can effectively prevent collapse and dimensional deformation of peri-implant soft tissues.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Dong Chen, Pengbo Chang, Peng Ding, Shuang Liu, Qi Rao, Oseweuba Valentine Okoro, Lingling Wang, Lihong Fan, Amin Shavandi, Lei Nie
Summary: In this study, a hydrogel containing mesenchymal stem cells (MSCs), silk fibroin (SF), and gelatin methacrylate (GelMA) was developed to encapsulate platelet-rich plasma (PRP) for repairing osteochondral defects and promoting cartilage regeneration. The MSCs-laden SG hydrogel loaded with PRP showed potential for cartilage reconstruction as confirmed by histological staining and scoring evaluations after injection into the cartilage defect area in rats. This research is important for the treatment of knee osteoarthritis.
Article
Materials Science, Biomaterials
Sandra Fuest, Ralf Smeets, Martin Gosau, Farzaneh Aavani, Christian Knipfer, Audrey Laure Celine Grust, Alexander Kopp, Mustafa Becerikli, Bjoern Behr, Levi Matthies
Summary: Biomaterials and coating techniques have significant benefits for advanced medical therapies. This study explores the layer-by-layer deposition of silk fibroin on different materials, showing promising results for modulating the body's immune response to implants. In vitro evaluations demonstrate that while silk fibroin coatings induce a higher inflammatory response, they do not affect hemocompatibility. Further in vivo studies are needed to confirm the effects on osteogenesis.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Physical
Chiara Cianci, David Chelazzi, Giovanna Poggi, Francesco Modi, Rodorico Giorgi, Marco Laurati
Summary: Silk artifacts are susceptible to degradation, but a combination of self-regenerated silk fibroin (SRSF) and cellulose nanocrystals (CNC) in dispersions shows promising results in improving the strength of aged fibers. The hybrid dispersions accelerate fibroin assembly, leading to the formation of more compact colloidal structures and the enhancement of crystalline structures in films, ultimately providing optimal axial strength to aged silk fibers. This innovative approach utilizing renewable materials could serve as effective tools for the preservation and restoration of historical textiles.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ahmed Elbrashy, Ahmed H. Osman, Mohamed Shawky, Niveen Askar, Mohamed Atef
Summary: This study compared the use of xenograft or platelet derived growth factor (PRF) in grafting the jumping gap during immediate implant placement. The results showed that the use of xenograft material resulted in superior outcomes in terms of crestal bone loss, buccolingual socket reduction, and implant stability quotient (ISQ) values compared to PRF.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joo-Hyung Yoon, Dae-Won Kim, Suk Keun Lee, Seong-Gon Kim
Summary: This study revealed that systemic administration of 4HR increased the weight of the submandibular glands in male rats. Furthermore, the expression levels of testosterone and VEGF in the submandibular glands were increased due to 4HR administration.
HEAD & FACE MEDICINE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Seong-Gon Kim
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, Research & Experimental
Yei-Jin Kang, Sang-Shin Lee, Seong-Gon Kim
Summary: A 75-year-old male patient presented with a 35-mm fluctuant lesion on the floor of the mouth. The lesion was a dome-shaped non-infiltrating angiolipoma, and it was successfully excised using an intraoral approach. This is the first reported case of this type of tumor being treated in this way in an elderly patient.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Seong-Gon Kim, Young-Wook Park, Ji-Hyeon Oh
Summary: This retrospective study analyzed the changes in condylar position following mandibular setback surgery with manual guidance. The results showed significant anterior-lateral-inferior movement of the condyle within 1 week after surgery, but the condyle returned to its original position over time.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Jwa-Young Kim, Yong-Chan Lee, Seong-Gon Kim, Umberto Garagiola
Summary: This comprehensive review explores the integration of 3D printing and Virtual Surgical Planning (VSP) in orthognathic and oral maxillofacial surgery, which enables personalized surgical methods, precise planning through tactile 3D models, and accurately designed surgical guides for improved patient-centric care and predictable outcomes.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Jwa-Young Kim, Seong-Gon Kim, Umberto Garagiola
Summary: The potential of sericin, a protein derived from silkworms, is explored for bone graft applications due to its biocompatibility, hydrophilic nature, and cost-effectiveness. It has antioxidant, anti-inflammatory, and UV-resistant properties that contribute to a healthier bone-healing environment, and its incorporation into 3D-printed grafts could lead to personalized medical solutions. However, gaps still exist in our understanding of sericin's mechanism of action, its long-term biocompatibility in humans, and the best methods for incorporating it into graft materials.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Min Keun Kim, Min Ji Ham, Won Rae Kim, Hyung Giun Kim, Kwang Jun Kwon, Seong Gon Kim, Young Wook Park
Summary: This study aimed to evaluate the accuracy of three-dimensional surgical guides and titanium implants in a rabbit model, as well as the surgical outcomes of mandibulectomy and reconstructive surgery. The accuracy of the implants was within the acceptable error range, while the surgical accuracy varied in different measured areas. The angle between the mandibular lower borders showed the most sensitive results, and the distance between the lingual cusps of the first molars represented the most accurate outcomes. The angle between the mandibular lower borders was found to be a good indicator for evaluating reconstructive surgery outcomes.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Seong-Gon Kim
Summary: This study evaluated the optimal scaffold material for silk sericin-based bone grafts using a critical-sized bone defect model in rat calvaria. The results showed that collagen exhibited better bone regeneration capability in silk sericin-based bone grafts compared to gelatin.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Yei-Jin Kang, Dae-Won Kim, Won-Geun Yang, Weon-Sik Chae, Seong-Gon Kim
Summary: The study demonstrates that pretreatment with 4-hexylresorcinol (4HR) increases the β-sheet structure of silk sericin, induces BMP-2 expression, and enhances bone regeneration ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yong-Chan Lee, Seong-Gon Kim
Summary: Orthognathic surgery has traditionally relied on traditional surgical planning, but the advent of virtual surgical planning (VSP) and 3D printing technologies has revolutionized the field, bringing unprecedented precision and customization. VSP allows for real-time adjustments and reduces planning time, while 3D printing enhances the predictability of surgical outcomes. The integration of VSP and 3D printing offers innovative solutions that surpass the limitations of traditional methods.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Dhouha Gaida, Young-Wook Park, Seong-Gon Kim
Summary: This study investigated the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, specifically in relation to diabetes-induced taste issues. The findings highlight the significant deterioration of taste buds in diabetic rats and suggest the potential therapeutic benefits of 4-HR in improving taste perception.
APPLIED SCIENCES-BASEL
(2023)
Meeting Abstract
Cell & Tissue Engineering
Seong-Gon Kim, Ji-Hyeon Oh, Yei-Jin Kang, HaeYong Kweon
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Seong-Gon Kim, Yei-Jin Kang, HaeYong Kweon, Ji-Hyeon Oh
TISSUE ENGINEERING PART A
(2022)
Review
Dentistry, Oral Surgery & Medicine
Seong-Gon Kim
Summary: The regeneration of bone is a challenging topic for maxillofacial plastic and reconstructive surgeons. Successful bone regeneration requires timely provision of essential components, including cellular components, extracellular matrix, and inorganic components. Selection of appropriate methods for personalized bone regeneration is crucial.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Seong-Gon Kim
Summary: 4-Hexylresorcinol is an amphiphilic organic compound that regulates microorganisms by inducing stress on the endoplasmic reticulum and altering protein folding. It inhibits the NE-kappa B signal pathway and TNF-alpha production, while increasing the production of angiogenesis and bone formation related proteins. It also demonstrates strong anti-inflammatory reaction and capillary regeneration in diabetic models, making it applicable for various types of surgical wounds.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
