Article
Agriculture, Dairy & Animal Science
C. M. Ylioja, A. J. Carpenter, L. K. Mamedova, K. M. Daniels, P. J. Ross, S. L. Laflin, T. H. Swartz, B. J. Bradford
Summary: The study evaluated the impact of sodium salicylate treatment on mammary gland changes in multiparous Holstein cows. Results showed no significant effects on milk yield or plasma metabolites, but differential gene expression and downregulation of immune-related pathways were observed. Further investigation into epigenetic effects on milk production is warranted.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Pediatrics
Chelsea M. Torres, Andrew S. Geneslaw, Leanne Svoboda, Arthur J. Smerling, Katherine R. Schlosser Metitiri
Summary: This study evaluated the relationship between intravenous acetaminophen and opioid exposure after cardiac surgery. Comparing before and after the implementation of a standardized pain pathway, it was found that opioid exposure decreased (0.38 milligram per kilogram of morphine equivalents [IQR 0.10-0.81] vs 0.26 milligram per kilogram of morphine equivalents [0.09-0.56], P =.01) and acetaminophen exposure increased (3 [2-4] vs 4 [4-5] doses, P <.001).
JOURNAL OF PEDIATRICS
(2023)
Review
Surgery
Chengyu Hou, Feng Liu, Chengbin Liu
Summary: This study reviewed the efficacy of submucosal administration compared with intravenous or intramuscular injections of dexamethasone for mandibular third molar surgery outcomes, finding similar results across various parameters but with low-quality evidence. Further high-quality randomized controlled trials are needed to confirm these conclusions.
FRONTIERS IN SURGERY
(2021)
Review
Chemistry, Medicinal
Mohammad Ali Goudarzi, Mohammad Radfar, Zohreh Goudarzi
Summary: Inflammation, a defense mechanism of the body against injury or infection, contributes to the development of chronic diseases. Peppermint and its main component, menthol, have been found to have anti-inflammatory potential by inhibiting various pathways involved in inflammation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Erin M. Corsini, Nicolas Zhou, Mara B. Antonoff, Reza J. Mehran, David C. Rice, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Wayne L. Hofstetter
Summary: This study investigated the use of ketorolac in patients undergoing esophagectomy and found no significant association with postoperative bleeding or renal dysfunction. Data showed a gradual increase in the use of ketorolac over the years following surgery. Furthermore, subgroup analysis based on dosage and patients receiving trimodality therapy did not demonstrate a relationship between ketorolac and postoperative adverse events.
ANNALS OF THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Yiyuan Xia, Yifan Xiao, Zhi-Hao Wang, Xia Liu, Ashfaqul M. Alam, John P. Haran, Beth A. Mccormick, Xiji Shu, Xiaochuan Wang, Keqiang Ye
Summary: This study reveals that gut dysbiosis is associated with Alzheimer's disease (AD) pathogenesis and certain Bacteroides strains are found to be elevated in the gut microbiota of AD patients. Specifically, Bacteroides fragilis and its metabolites 12-HHTrE and PGE2 are shown to activate microglia and induce AD pathologies. Moreover, recolonization of mice with AD patient fecal samples containing these Bacteroides strains leads to the development of AD pathologies, accompanied by upregulation of the C/EBP beta/Asparaginyl endopeptidase (AEP) pathway, microglia activation, and cognitive disorders. The findings suggest a causal role for Bacteroides fragilis and its metabolites in activating microglia and inducing AD pathologies in transgenic mice.
NATURE COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zaid Tamimi, Rola Al Habashneh, Islam Hamad, Mutasim Al-Ghazawi, Ala' Abu Roqa'a, Hamza Kharashgeh
Summary: A randomized clinical trial involving 133 patients showed that the use of Serratipeptidase for 5 days after surgical removal of impacted lower third molars significantly improved trismus and swelling, but showed no significant difference in relieving pain.
Article
Medicine, General & Internal
Francisco Javier Quesada-Bravo, Ana Rocio Garcia-Carricondo, Fernando Espin-Galvez, Carmen Fernandez-Sanchez, Damaso Fernandez-Gines, Maria del Mar Requena-Mullor, Raquel Alarcon-Rodriguez
Summary: The study compared the benefits of combining dexamethasone-bupivacaine with articaine-epinephrine as an anesthetic block after third molar surgery. Results showed that the combination significantly reduced postoperative pain and decreased analgesic drug consumption, supporting the use of bupivacaine as an alternative to articaine in oral surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Sydney E. Reed, Hon Sen Tan, Matthew E. Fuller, Vijay Krishnamoorthy, Tetsu Ohnuma, Karthik Raghunathan, Ashraf S. Habib
Summary: Following cesarean delivery under neuraxial anesthesia, only a small percentage of parturients received the currently recommended multimodal analgesic regimen of neuraxial morphine with NSAIDs and acetaminophen, while the majority received acetaminophen-opioid combination drugs. Further investigation should focus on the implications of this practice on patient outcomes.
ANESTHESIA AND ANALGESIA
(2021)
Article
Oncology
Lauren M. Hurwitz, Mary K. Townsend, Susan J. Jordan, Alpa V. Patel, Lauren R. Teras, James V. Lacey, Jennifer A. Doherty, Holly R. Harris, Marc T. Goodman, Yurii B. Shvetsov, Francesmary Modugno, Kirsten B. Moysich, Kim Robien, Anna Prizment, Joellen M. Schildkraut, Andrew Berchuck, Renee T. Fortner, Andrew T. Chan, Nicolas Wentzensen, Patricia Hartge, Dale P. Sandler, Katie M. O'Brien, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Susan J. Ramus, Celeste Leigh Pearce, Anna H. Wu, Emily White, Ulrike Peters, Penelope M. Webb, Shelley S. Tworoger, Britton Trabert
Summary: The study found that frequent aspirin use is associated with lower ovarian cancer risk, regardless of other ovarian cancer risk factors in subgroups.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Dafne Chisci, Stefano Parrini, Nicola Baldini, Glauco Chisci
Summary: The purpose of this study was to explore patterns of pre-operative pain and test for the relationship between symptom patterns (such as pain intensity, tooth location, and referred pain area) and third molar extraction surgery. A retrospective observational study was conducted on 86 patients, and a significant correlation was found between pain score and pain area. The study concludes that pain intensity plays a role in determining the orofacial distribution of pain.
Article
Oncology
Lorena Marcano-Bonilla, Cathy D. Schleck, William S. Harmsen, Omid Sadr-Azodi, Mitesh J. Borad, Tushar Patel, Gloria M. Petersen, Terry M. Therneau, Lewis R. Roberts, Nele Brusselaers
Summary: This study found that statins were associated with a decreased risk of biliary tract cancers and its subtypes. Low-dose aspirin alone was not associated with decreased risk, and the use of both statins and low-dose aspirin did not further decrease the risk. NSAIDs were associated with a higher risk of biliary tract cancers, while metformin was not associated with the risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ehsan Momeni, Hoda Barati, Melika Rajaei Arbabi, Behrouz Jalali, Mahdieh-Sadat Moosavi
Summary: The study aimed to determine the effect of LLLT on reducing pain, swelling, and trismus following the mandibular impacted third molar surgery. While pain, swelling, and trismus were lower on the radiated side, only pain was found to be significant on the radiated side.
Article
Medicine, General & Internal
Jeong-Kui Ku, Jae-Young Kim, Mi-Kyoung Jun, Yeong Kon Jeong, Jong-Ki Huh
Summary: This study compared the effects of general anesthesia and local anesthesia on postoperative pain levels following third molar extractions. The results showed that the duration of the operation was more correlated with postoperative pain than the type of anesthesia used.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Haley M. Oberhofer, Adityanarayan Rao, Jacob T. Carlson, Bruce A. Mast, Christopher J. Simmons, Karol A. Gutowski, Ellen S. Satteson
Summary: This study aimed to provide comprehensive data on postoperative analgesic prescribing patterns among members of the American Society of Plastic Surgeons (ASPS), and to facilitate evaluation and improvement of opioid use.
ANNALS OF PLASTIC SURGERY
(2022)
