Article
Biochemistry & Molecular Biology
Zhiyuan Dou, Chunping Qiu, Xun Zhang, Shu Yao, Chen Zhao, Zixiang Wang, Ran Chu, Jingying Chen, Zhongshao Chen, Rongrong Li, Kun Wang, Penglin Liu, Chang Liu, Kun Song, Beihua Kong
Summary: This study found that HJURP is overexpressed in ovarian cancer and is associated with unfavorable prognosis. Knockdown of HJURP inhibits proliferation, metastasis, and induces cell stagnation in ovarian cancer cells. Mechanistically, HJURP regulates WEE1 through the MYC pathway, affecting chemosensitivity and DNA repair in ovarian cancer cells. Moreover, silencing HJURP enhances sensitivity to cisplatin and improves the synergistic effect of combined therapy with cisplatin and AZD1775 in ovarian cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jian-Lei Zhao, Jun Yang, Ke Li, Yang Chen, Mei Tang, Hui -Li Zhu, Chun-Lai Nie, Zhu Yuan, Xin-Yu Zhao
Summary: Targeting replication stress response is a promising therapeutic strategy for breast tumors, and combination therapy of ATR inhibitor and cisplatin may offer potential benefits.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Cristina Mir, Yoelsis Garcia-Mayea, Laia Garcia, Pol Herrero, Nuria Canela, Rocio Tabernero, Juan Lorente, Josep Castellvi, Eva Allonca, Juana Garcia-Pedrero, Juan Pablo Rodrigo, Angel Carracedo, Matilde Esther LLeonart
Summary: Syntenin-1 (SDCBP) has been identified as an important protein involved in chemoresistance and stemness of HNSCC tumors. Depletion of SDCBP sensitizes HNSCC cells to cisplatin and reduces CSC markers. SDCBP expression is associated with Src activation, poorly differentiated tumor grade, advanced tumor stage, and shorter survival rates in a series of 382 HNSCC patients, indicating it may be a promising therapeutic target for eliminating CSCs and cisplatin resistance.
Article
Dentistry, Oral Surgery & Medicine
Shomereeta Roy, Souvick Roy, Kumari Anuja, Shweta Thakur, Yusuf Akhter, Swatishree Padhi, Birendranath Banerjee
Summary: The study showed that inhibiting p38 resulted in decreased expression of CSC markers and beta-catenin in cisplatin resistant HNSCC cells, as well as reduced migration potential and sphere forming ability. Additionally, there was an increase in apoptotic index, indicating increased sensitivity to cisplatin.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Oncology
Nan Zuo, Lin Ma, Tianyang Liu, Weitao Hu, Yupeng Luo, He Meng, Qiushi Ren, Yongqiang Deng, Lanlan Wei, Qi Liu
Summary: HPV-positive head and neck squamous cell carcinoma (HNSCC) has a better prognosis and greater cisplatin sensitivity compared to their HPV-negative counterparts. Understanding the molecular mechanisms underlying HPV-induced cisplatin sensitivity is crucial for improving the prognosis of HPV-negative HNSCC. This study revealed a deficiency in the Fanconi anemia (FA) pathway and reduced XPF expression in HPV-positive HNSCC cells. Inhibiting XPF increased the activity of the alternative end-joining (alt-EJ) pathway in HPV-negative HNSCC, leading to enhanced cisplatin sensitivity. Combining FA and alt-EJ inhibition may be a strategy to treat HPV-negative HNSCC.
Article
Cell Biology
Yu-Ying Chao, Bu-Miin Huang, I-Chen Peng, Pei-Rong Lee, Yi-Shyun Lai, Wen-Tai Chiu, Yi-Syuan Lin, Shih-Chieh Lin, Jung-Hsuan Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Chia-Yih Wang
Summary: Loss of primary cilia is associated with chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Disruption of primary ciliogenesis sensitizes PDAC cells to cisplatin treatment, indicating a potential therapeutic strategy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Medicine, Research & Experimental
Xuanyu Zhang, Chao Shang, Xue Qiao, Yan Guo
Summary: This review summarizes the role of immunogenic cell death (ICD) and its biomarkers in the chemoresistance of head and neck squamous cell carcinoma (HNSCC). ICD can improve patient survival and prognosis, and can be used as molecular markers for tumor diagnosis and prognosis. Additionally, the key biomarkers of ICD can be developed into new targets for regulating HNSCC chemoresistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Neha Khera, Asvika Soodhalaagunta Rajkumar, Khlood Abdulkader M. Alkurdi, Zhiao Liu, Hong Ma, Ahmad Waseem, Muy-Teck Teh
Summary: Through transcriptome datamining, 10 multidrug chemoresistance genes were identified in head and neck squamous cell carcinoma. Among them, NEK2 and INHBA showed significant prognostic values in multiple cancer types. Drug library screens discovered two compounds targeting INHBA and NEK2, which resensitized cisplatin-resistant cells.
Article
Immunology
Konjit Getachew Muleta, Isabel Ulmert, Kedir Hussen Hamza, Sharne van Dijl, Joy Nakawesi, Katharina Lahl
Summary: Rotavirus (RV) infection induces strong adaptive immunity, with initial clearance depending on cytotoxic CD8 T cells. Type I classical dendritic cells (cDC1) play a key role in CD8 T cell induction and RV cytotoxicity. This study found that the individual Toll-like receptor 3 (TLR3) and MyD88-mediated signaling pathways were not required for CD8 T cell response or RV clearance. Surprisingly, absence of type I interferon (IFN) signaling did not alter the accumulation of RV-specific CD8 T cells, but it impaired their ability to produce IFN gamma and granzyme.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Shuyan Sheng, Wenzhuo Su, Deshen Mao, Conghan Li, Xinyang Hu, Wanyu Deng, Yong Yao, Yongsheng Ji
Summary: Drug resistance can impair treatment effects and miR-21 may facilitate the development or maintenance of drug resistance in cancer cells. Restoring drug sensitivity by inhibiting miR-21 expression can improve therapeutic strategies.
Article
Oncology
Amandine Moretton, Jana Slyskova, Marwan E. Simaan, Emili A. Arasa-Verge, Mathilde Meyenberg, D. Alonso Cerron-Infantes, Miriam M. Unterlass, Joanna I. Loizou
Summary: In this study, a series of cisplatin derivatives compatible with click chemistry were synthesized to investigate the repair of DNA crosslinks and cellular responses. It was found that these compounds bind to DNA and generate DNA damage. They can be visualized and quantified in cells through fluorescence probes and biotin tagging, respectively. Furthermore, one of the compounds can be used to identify DNA repair proteins.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Shuo Yang, Zhi-Jun Yuan, Yue-Hong Zhu, Xue Chen, Wei Wang
Summary: The study revealed that lncRNA PVT1 decreases the sensitivity of HNSCC cells to cetuximab by enhancing methylation-mediated inhibition of miR-124-3p, providing a new insight into the cetuximab chemoresistance of HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Medicine, Research & Experimental
Jitendra Gupta, Abdulrahman T. Ahmed, Nahla A. Tayyib, Rahman S. Zabibah, Qakhramon Shomurodov, Mostafai N. Kadheim, Fahad Alsaikhan, Pushpamala Ramaiah, Lathamangeswari Chinnasamy, Saeed Samarghandian
Summary: This article focuses on the emergence of cisplatin resistance in gastric cancer cells, with a focus on molecular pathways, pharmacological compounds, and nanostructures. It highlights the role of non-coding RNAs and exosomes in determining cisplatin response in gastric cancer cells. The use of nanoplatforms for delivery of cisplatin in gastric cancer therapy is also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Faezeh Tolue Ghasaban, Amirhosein Maharati, Amir Sadra Zangouei, Alireza Zangooie, Meysam Moghbeli
Summary: Although there is a good prognosis for early stage head and neck tumors, half of them are detected at an advanced stage with poor prognosis. The combination of chemotherapy, radiotherapy, and surgery is the treatment option for head and neck cancer patients. Cisplatin is the first-line drug for HNC patients, but resistance to cisplatin is common. This review investigates the role of microRNAs in cisplatin response in head and neck tumors, suggesting a non-invasive miRNA panel marker for predicting cisplatin response and improving clinical outcomes.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.