Journal
ORAL ONCOLOGY
Volume 50, Issue 5, Pages 380-386Publisher
ELSEVIER
DOI: 10.1016/j.oraloncology.2013.12.019
Keywords
Human papillomavirus; Oropharyngeal cancer; Epidemiology
Categories
Funding
- NCI NIH HHS [R25 CA057730] Funding Source: Medline
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Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC. (C) 2014 Elsevier Ltd. All rights reserved.
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