Journal
ORAL ONCOLOGY
Volume 50, Issue 10, Pages 991-999Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2014.06.012
Keywords
Adenoid cystic carcinoma; Cell line; Salivary gland tumors
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Funding
- NIH National Institute of Dental and Craniofacial Research
- NIH Office of Rare Diseases Research [HHSN268200900039C]
- The Salivary Gland Tumor Bank (SGTB)
- The Kenneth D. Muller professorship
- NCI [CA-16672]
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Objective: To develop in vitro adenoid cystic carcinoma cell line as a surrogate for functional studies. Materials and methods: Cells obtained from a primary ACC of the base of tongue were cultivated in vitro and immortalized with h-TERT. Morphologic, cytogenetic and functional studies were performed. Results: Tumor cells were verified by positive reactions to keratin and smooth muscle actin and phenotypic cellular and nuclear features. In-vitro cell growth and colony formation assay supported their tumor nature. Conclusion: We authenticated an ACC cell line with hybrid epithelial-myoepithelial feature as a resource for functional experimentation. (C) 2014 Elsevier Ltd. All rights reserved.
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