Article
Medicine, Research & Experimental
Shirley Lewis, Saket Pandey, Naveen Salins, Jayita Deodhar, Vijay Patil, Tejpal Gupta, Sarbani Ghosh Laskar, Ashwini Budrukkar, Vedang Murthy, Amit Joshi, Kumar Prabhash, Sudhir Nair, Pankaj Chaturvedi, Vanita Noronha, Jai Prakash Agarwal
Summary: This study aimed to estimate the prevalence of baseline distress in head and neck cancer patients undergoing radical intent radiotherapy, finding that 56% of patients had clinically significant distress. Factors predictive of distress included low socioeconomic status, presence of proliferative growth, tumor site, comorbidity, and medical devices at baseline. Patients with low socioeconomic status had higher distress levels, highlighting the need for interventions to alleviate distress.
Article
Health Care Sciences & Services
Sonia Silva, Tiago Paredes, Ricardo Joao Teixeira, Tania Brandao, Klara Dimitrovova, Diogo Marques, Joana Sousa, Monick Leal, Albina Dias, Carole Neves, Graciete Marques, Natalia Amaral
Summary: This study assessed emotional distress in a large sample of cancer patients attending psychological services at an NGO, finding that factors such as sadness, depression, sleep, breathing, being female, and being in the palliative phase were significantly associated with higher levels of distress. The results highlight the importance of early emotional screening and individualized care for cancer patients.
Article
Psychology, Multidisciplinary
David Macias, Brittany N. Hand, Patrik Pipkorn, Amy M. Williams, Steven S. Chang, Joseph Zenga, Marci L. Nilsen, Bethany A. Rhoten, Andrew T. Huang, Nosayaba Osazuwa-Peters, Stacey Maurer, Wendy Balliet, Hong Li, Kenneth J. Ruggiero, Katherine R. Sterba, Evan M. Graboyes
Summary: The study aimed to determine the cut-off score for Inventory to Measure and Assess Image disturbance - Head and Neck (IMAGE-HN) that identifies head and neck cancer patients with clinically relevant body image-related distress (BID). An IMAGE-HN score of >= 22 was found to be optimal, identifying patients with clinically relevant BID. Patients above this cut-off score showed significantly higher levels of depression and anxiety symptoms, as well as worse quality of life.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Bryan Gascon, Aliza A. Panjwani, Olivia Mazzurco, Madeline Li
Summary: Head and neck cancer patients have higher rates of emotional distress compared to other cancer types and the general population. This study compares the prevalence of emotional distress in head and neck cancer patients using different screening measures and explores the relationship between significant distress and cancer-related survival.
Article
Oncology
Wei-Ting Tseng, Yu Lee, Chi-Fa Hung, Pao-Yen Lin, Chih-Yen Chien, Hui-Ching Chuang, Fu-Min Fang, Shau-Hsuan Li, Tai-Lin Huang, Mian-Yoon Chong, Liang-Jen Wang
Summary: The study found that patients with head and neck cancer (HNC) experience stigma, anxiety, and depression, with a significant correlation between them. Stressors can also impact the level of stigma in these patients. Proper identification of comorbidities and reducing stigma should be recommended in mental health efforts for HNC patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Dentistry, Oral Surgery & Medicine
Leticia Rodrigues-Oliveira, Elisa Kauark-Fontes, Carolina Guimaraes Bonfim Alves, Juliana Ono Tonaki, Luiz Alcino Gueiros, Karina Moutinho, Gustavo Nader Marta, Luciana Rodrigues Carvalho Barros, Alan Roger Santos-Silva, Thais Bianca Brandao, Ana Carolina Prado-Ribeiro
Summary: The study found that anxiety, depression, and distress levels in head and neck cancer patients undergoing radiotherapy did not increase during the COVID-19 pandemic. Patients were afraid of being infected by COVID-19, but still complied with their cancer treatment.
Article
Oncology
Zachary M. Kassir, Jinhong Li, Christine Harrison, Jonas T. Johnson, Marci L. Nilsen
Summary: This study found that some caregivers have a more negative perception of patients' quality of life than the patients themselves, and these caregivers tend to experience higher levels of psychosocial distress. Accordingly, interventions to identify and aid at-risk caregivers are critically needed.
Article
Nursing
Ziyao Guan, Wendy Cross, Louisa Lam, James A. Wiley, Mei Sun, Xiaoling Bai, Siyuan Tang
Summary: The study found that the DT is an effective tool in identifying distress among family members of adults diagnosed with schizophrenia, with a cut-off score of six maximizing sensitivity and specificity at 77% and 76% respectively. Over half of the family members reached this cut-off score and experienced significant distress. Distress levels were higher in family members of male patients, parents, and those with a primary school education or below, highlighting the importance of providing screening and interventions for distressed family members.
JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
(2021)
Article
Oncology
Flavia Vicinanza, Edy Ippolito, Antonella Sisto, Bianca Santo, Michele Fiore, Luca Eolo Trodella, Sonia Silipigni, Livia Quintiliani, Sara Ramella
Summary: This study evaluated the psychological impact of the COVID-19 pandemic on cancer patients undergoing radiotherapy. The results showed that 37% of patients experienced significant distress, 22.4% reported depressive symptoms, and 99% of the sample had clinically significant anxiety symptoms. In addition, all patients experienced worsened anxiety during the COVID-19 pandemic, and patients on active treatment had higher levels of distress and anxiety. Lung cancer patients appeared to be more afraid of COVID-19 than other patients.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Deborah A. Forst, Alyx F. Podgurski, Kit M. Quain, Sophia L. Landay, Maya Anand, Emilia Kaslow-Zieve, Michelle M. Mesa, Jamie M. Jacobs, Jorg Dietrich, Michael W. Parsons, Nora Horick, Joseph A. Greer, Tracy T. Batchelor, Vicki A. Jackson, Areej El-Jawahri, Jennifer S. Temel
Summary: Male gender, higher caregiver burden, greater patient depression symptoms, and younger patient age are associated with increased distress among caregivers of patients with malignant gliomas.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Linda McCabe-White, Nima Moghaddam, Anna Tickle, Sanchia Biswas
Summary: Studies have identified various factors associated with psychological distress in couples facing Head and Neck Cancer, including disease burden, reduced social contact, perception of reduced relationship quality, and less adaptive coping. While the effect sizes varied considerably, overall the studies had good methodological quality but could be improved by minimizing non-response bias and fully reporting relational characteristics.
Article
Medicine, Research & Experimental
Eden R. Brauer, Stephanie Lazaro, Charlene L. Williams, David A. Rapkin, Amy B. Madnick, Roger Dafter, Guo Cheng, Ashleigh Porter, Elliot Abemayor, Wanxing Chai-Ho, Elizabeth Morasso, Andrew Erman, Dinesh Chhetri, Maie St John, Deborah J. Wong
Summary: Psychosocial distress is common among head and neck cancer patients, with 57% reporting clinical distress in this study. Factors such as pain, fatigue, anxiety, and depression were significantly associated with clinical distress. A high percentage of distressed patients received same-day psychosocial evaluation, suggesting the feasibility of implementing a brief screening protocol in routine oncology care.
Article
Oncology
Alexandria Harris, Jinhong Li, Karley Atchison, Christine Harrison, Daniel Hall, Tyler VanderWeele, Jonas T. Johnson, Marci L. Nilsen
Summary: This study evaluates the relationship between demographics, clinical characteristics, and posttreatment symptom burden with the subjective sense of flourishing among head and neck cancer survivors. The results suggest that late- and long-term side effects of treatment and financial hardship are associated with lower levels of flourishing.
Article
Oncology
Tongyao Wang, Susan R. Mazanec, Nicholas K. Schiltz, Nipun Chhabra, Rod Rezaee, Joachim G. Voss
Summary: This observational study describes post-traumatic distress in patients with head and neck cancer-related tracheostomy and their family caregivers. The results show that post-traumatic distress related to tracheostomy and general depression is highly prevalent. Higher levels of physical symptoms are moderately correlated with higher levels of post-traumatic distress.
ONCOLOGY NURSING FORUM
(2023)
Article
Health Care Sciences & Services
Lisa Graham-Wisener, Martin Dempster, Aaroon Sadler, Luke McCann, Noleen K. McCorry
Summary: The Distress Thermometer is a valid and accurate screening tool for advanced cancer patients, but caution is needed due to lack of specificity. In this study with 139 participants providing complete data, the optimal cut-off score on the Distress Thermometer was > 6 for total distress and anxiety, and > 4 for depression in patients with advanced cancer.
PALLIATIVE MEDICINE
(2021)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.