Article
Surgery
Zhouying Peng, Yumin Wang, Yaxuan Wang, Ruohao Fan, Kelei Gao, Hua Zhang, Zhihai Xie, Weihong Jiang
Summary: The study showed that for recurrent nasopharyngeal carcinoma, endoscopic endonasal nasopharyngectomy (EEN) is an effective treatment option with a 2-year overall survival rate of 48.6% and disease-free survival rate of 42.6%. Advanced T stages were associated with poor prognosis, indicating that T staging may be an independent prognostic factor.
FRONTIERS IN SURGERY
(2021)
Article
Oncology
Wanpeng Li, Huankang Zhang, Hanyu Lu, Huan Wang, Yurong Gu, Houyong Li, Xicai Sun, Hongmeng Yu, Dehui Wang
Summary: Salvage endoscopic nasopharyngectomy is effective in the management of advanced recurrent nasopharyngeal carcinoma, with factors such as patient age, BMI, tumor stage, and invasion significantly impacting prognosis. Further large-scale studies are needed to compare the efficacy of endoscopic surgery with re-irradiation in this patient population.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jing Feng Zong, Po-Ju Lin, Hsiao-Hui Tsou, Qiaojuan Guo, Yi-Chun Liu, Hanchuan Xu, Chih-Wen Twu, Wei Zheng, Rong-San Jiang, Kai -Li Liang, Tian-Yun Lin, Jian Ji Pan, Shao Jun Lin, Jin-Ching Lin
Summary: The purpose of this study was to compare the acute toxicity of two different induction chemotherapy regimens in patients with advanced nasopharyngeal carcinoma. The results showed that the weekly chemotherapy regimen significantly reduced acute toxicities and had higher complete response rates and lower relapse rates, without compromising tumor response and survivals.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
An-An Xu, Jing-Jing Miao, Lin Wang, An-Chuan Li, Fei Han, Xun-Fan Shao, Zhi-Wen Mo, Shao-Min Huang, Ya-Wei Yuan, Xiao-Wu Deng, Chong Zhao
Summary: This study analyzed the clinical outcomes of concurrent chemoradiotherapy (CCRT) alone for loco-regionally advanced nasopharyngeal carcinoma (LANPC) based on 10-year results, aiming to provide evidence for individualized treatment strategy and designing appropriate clinical trial for different risk LANPC patients.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Quan Liu, Xicai Sun, Han Li, Jiaying Zhou, Yurong Gu, Weidong Zhao, Houyong Li, Hongmeng Yu, Dehui Wang
Summary: In this study, types of Transnasal Endoscopic Nasopharyngectomy (TEN) for recurrent Nasopharyngeal Carcinoma (rNPC) were established, showing promising results in the treatment of rNPC. The types of TEN provide effective guidelines for the surgical treatment of rNPC, with factors such as recurrent T stage, type of TEN, and surgical margin being independent predictors of outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Zhi-Qiang Wang, Yu-Long Xie, You-Ping Liu, Xiong Zou, Jin-Hua Chen, Yi-Jun Hua, Yang-Kui Gu, Yan-Feng Ouyang, Zi-Kun Yu, Rui Sun, Pei-Yu Huang, Ming-Yuan Chen
Summary: Salvage ENPG combined with ICA pretreatment is a feasible and effective surgical option for resecting rNPC lesions adjacent to the ICA, with promising survival rates and manageable postoperative complications.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Oncology
Jing-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo, Yun Xu, Cai-Rong Hu, Jian-Ji Pan, Shao-Jun Lin
Summary: This study compared the efficacy and toxicity of radiotherapy combined with nimotuzumab versus chemoradiotherapy in patients with locally recurrent nasopharyngeal carcinoma. The results showed no significant difference in survival rates between the two groups, but the CRT group had a higher incidence of severe late radiation injuries. Further studies are needed to confirm these findings.
Article
Otorhinolaryngology
Raymond K. Tsang, Walter C. P. Chan, Floyd Christopher Holsinger, Joseph C. K. Chung, Velda L. Y. Chow, Jimmy Y. W. Chan, Wai-Kuen Ho, William Wei
Summary: This study presents the experience of 33 cases of robotic-assisted nasopharyngectomy, with a focus on local recurrent nasopharyngeal carcinoma. The study shows a high local control rate of 85.1% and a median follow-up period of 38 months.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Lin Su, Lei She, Liangfang Shen
Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Benjian Zhang, Yiliang Li, Jingjin Weng, Bo Huang, Molu Ban, Guiping Lan, Yu Lu, Jianhui Luo, Shenhong Qu, Yongfeng Si
Summary: The study assessed the feasibility and safety of ENPG combined with LDRT in T1-2 NPC patients, demonstrating that this treatment provided satisfactory survival outcomes, improved QoL, and reduced the incidence of sequelae.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Immunology
Zhouying Peng, Yumin Wang, Yan Fang, Yaxuan Wang, Xiaotian Yuan, Mingxia Shuai, Shumin Xie, Ruohao Fan, Hua Zhang, Zhihai Xie, Weihong Jiang
Summary: This study analyzed the efficacy of immunotherapy for patients with recurrent nasopharyngeal carcinoma (NPC) and explored the possibility of salvage endoscopic skull base nasopharyngectomy. The study found that PD-1 immunotherapy may improve the remission rate in patients with recurrent NPC. Salvage endoscopic skull base nasopharyngectomy could be another option for patients with poor immunotherapeutic outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Wai Tong Ng, Yoke Lim Soong, Yong Chan Ahn, Hussain AlHussain, Horace C. W. Choi, June Corry, Vincent Gregoire, Kevin J. Harrington, Chao Su Hu, Kenneth Jensen, Dora L. Kwong, Johannes A. Langendijk, Quynh Thu Le, Nancy Y. Lee, Jin Ching Lin, Tai Xiang Lu, William M. Mendenhall, Brian O'Sullivan, Enis Ozyar, Jian Ji Pan, Lester J. Peters, Sharon S. Poh, David I. Rosenthal, Giuseppe Sanguineti, Yungan Tao, Joseph T. Wee, Sue S. Yom, Melvin L. K. Chua, Anne W. M. Lee
Summary: The reirradiation for locally recurrent nasopharyngeal carcinoma (NPC) is challenging due to the delicate balance needed between achieving local salvage and minimizing treatment toxicities. High-level evidence is lacking, but pragmatic consensus guidelines based on expert opinions provide useful references for decision-making. Through iterative revisions, recommendations with high-to-moderate agreement were formulated regarding general treatment strategies and details of reirradiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Otorhinolaryngology
Xiong Zou, Zheng-Kai Feng, Yi-Jun Hua, You-Ping Liu, Yu-Long Xie, Yan-Feng Ouyang, Yong-Long Liu, Zhi-Qiang Wang, Rui You, Xi Ding, Qi Yang, Zi-Kun Yu, Pei-Yu Huang, Shun-Lan Wang, Ming-Yuan Chen
Summary: This study investigated the use of low-temperature plasma radiofrequency ablation for radical endoscopic nasopharyngectomy in resectable localized recurrent nasopharyngeal carcinoma (rNPC) and found it to be a safe and simplified method with good survival benefits.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen, Yun-Fei Xia
Summary: The optimal treatment strategy for de novo metastatic nasopharyngeal carcinoma (mNPC) is a combination of palliative chemotherapy (PCT) followed by concurrent chemoradiotherapy. Specifically, concurrent chemoradiotherapy with single-agent platinum after 4-6 cycles of PCT is suggested to achieve better survival outcomes.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Rui You, You -Ping Liu, Yu -Long Xie, Chao Lin, Chong -Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong -Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si -Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan Chen
Summary: This study compared the efficacy and safety of hyperfractionation with standard fractionation in intensity-modulated radiotherapy. The results showed that hyperfractionation significantly reduced the incidence of severe late complications and improved overall survival, suggesting that it could be used as the standard of care for patients with locally advanced recurrent nasopharyngeal carcinoma.
Article
Oncology
Dong Pan, Xiaoming Rong, Yingying Zhu, Wai Tong Ng, Dongping Chen, Honghong Li, Yongteng Xu, Yamei Tang
Summary: This study developed and validated a nomogram to predict overall survival in head and neck cancer survivors following the diagnosis of radiation-induced brain necrosis (RN). The nomogram showed favorable performance in both internal and external validation cohorts, indicating its clinical usefulness.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Sandra Nuyts, Heleen Bollen, Sweet Ping Ng, June Corry, Avraham Eisbruch, William M. Mendenhall, Robert Smee, Primoz Strojan, Wai Tong Ng, Alfio Ferlito
Summary: Proton therapy is a promising radiation therapy method for improving outcomes in head and neck cancer patients. It can minimize radiation dose to surrounding vital structures, reducing toxicity. However, current evidence on its effectiveness is limited, leading to scarce reimbursement indications in most countries. Despite this, there are approximately 100 proton therapy centers worldwide, and initial experiences for head and neck cancer are being reported. This review aims to summarize the early clinical experience and challenges of proton therapy for head and neck cancer.
Review
Oncology
Kazi Anisha Islam, Larry Ka-Yue Chow, Ngar Woon Kam, Ying Wang, Chi Leung Chiang, Horace Cheuk-Wai Choi, Yun-Fei Xia, Anne Wing-Mui Lee, Wai Tong Ng, Wei Dai
Summary: This study investigates molecular biomarkers for prognostic prediction in patients with nasopharyngeal carcinoma (NPC). Seventeen important markers are identified, including genetic polymorphisms, methylation, microRNAs, mutation, and gene expression panels. These biomarkers can be used to predict patient survival and guide personalized therapy. The study also highlights the clinical need for a comprehensive evaluation of multiple types of biomarkers in a multicenter study, and these biomarkers are involved in various signaling pathways that could be potential therapeutic targets.
Article
Oncology
Zhiyuan Xu, Li Yang, Wai-Tong Ng, Aya El Helali, Victor Ho-Fun Lee, Lingyu Ma, Qin Liu, Jishi Li, Lin Shen, Jijie Huang, Jiandong Zha, Cheng Zhou, Anne W. M. Lee, Longhua Chen
Summary: This study evaluated the efficacy of reduced cumulative doses of induction and concurrent cisplatin in treating nasopharyngeal carcinoma. The results showed that the treatment scheme achieved similar favorable outcomes to the NPC-0501 trial with excellent tolerability.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Oncology
Melvin L. K. Chua, Joanne Y. H. Lua, Wai-Tong Ng, Anne W. M. Lee
CHINESE CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Leandro L. Matos, Alvaro Sanabria, K. Thomas Robbins, Gyorgy B. Halmos, Primoz Strojan, Wai Tong Ng, Robert P. Takes, Peter Angelos, Cesare Piazza, Remco de Bree, Ohad Ronen, Orlando Guntinas-Lichius, Avraham Eisbruch, Mark Zafereo, Antti A. Makitie, Ashok R. Shaha, Andres Coca-Pelaz, Alessandra Rinaldo, Nabil F. Saba, Oded Cohen, Fernando Lopez, Juan P. Rodrigo, Carl E. Silver, Timo E. Strandberg, Luiz Paulo Kowalski, Alfio Ferlito
Summary: The projected increase in life expectancy is expected to lead to a rise in age-related diseases, including cancer. This report critically reviews the literature on managing older patients with head and neck cancer (HNC). Older adults, especially those who are frail or have comorbidities, are more prone to complications and toxicities from HNC treatment. Screening older patients for predispositions and managing comorbidities is essential. Age alone should not be a determining factor for less intensive treatment, and older patients should be treated according to the best standard of care to avoid increased treatment failure rates and mortality. A multidisciplinary tumor board should establish the treatment plan, involving shared decision-making with patients and family, and treatment modifications should be considered for patients with severe comorbidities, frailty, or who refuse recommendations.
ADVANCES IN THERAPY
(2023)
Article
Medicine, General & Internal
Rui You, You -Ping Liu, Yu -Long Xie, Chao Lin, Chong -Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong -Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si -Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan Chen
Summary: This study compared the efficacy and safety of hyperfractionation with standard fractionation in intensity-modulated radiotherapy. The results showed that hyperfractionation significantly reduced the incidence of severe late complications and improved overall survival, suggesting that it could be used as the standard of care for patients with locally advanced recurrent nasopharyngeal carcinoma.
Article
Oncology
Alan W. L. Mui, Anne W. M. Lee, Wai-Tong Ng, Victor H. F. Lee, Varut Vardhanabhuti, Shei-Yee Man, Daniel T. T. Chua, Xin-Yuan Guan
Summary: This study aimed to investigate the optimal time for early therapeutic response prediction with multi-parametric magnetic resonance imaging (MRI) in patients with nasopharyngeal carcinoma (NPC) receiving concurrent chemo-radiotherapy (CCRT). The results showed that DW-MRI on week-1 and DCE-MRI on week-2 can serve as the optimal time points for early therapeutic response prediction.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Aya El Helali, Tai-Chung Lam, Elaine Yee-Ling Ko, David J. H. Shih, Chun Kau Chan, Charlene H. L. Wong, Jason W. H. Wong, Lydia W. T. Cheung, Johnny K. S. Lau, Anthony P. Y. Liu, Ann S. Y. Chan, Herbert H. Loong, Stephen Tak Sum Lam, Godfrey Chi-Fung Chan, Victor H. F. Lee, Kwok Keung Yuen, Wai-Tong Ng, Anne W. M. Lee, Edmond S. K. Ma
Summary: This study investigated the feasibility of the HKU-HKSH Multi-disciplinary Molecular Tumour Board (MTB) in determining genome-guided therapy for treatment-refractory solid cancers in Hong Kong. The results showed that MTB-guided treatment positively impacted patients' overall survival, illustrating the applicability of next-generation sequencing comprehensive gene profiling (CGP) in real-world clinical practice.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Editorial Material
Oncology
Ezra Hahn, Wai Tong Ng
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Oncology
Yiling Li, Fengyuan Gong, Yangyang Guo, Wai Tong Ng, Michael Benedict A. Mejia, Wen-Long Nei, Cuicui Wang, Zhanguo Jin
Summary: Radiotherapy is a common treatment for nasopharyngeal carcinoma (NPC) but can cause radiation-induced temporal lobe injury (RTLI). Predicting RTLI at the early stage using machine learning (ML) models can help personalize radiation dose adjustment. However, the accuracy of these models remains unclear, warranting a meta-analysis for evaluation.
TRANSLATIONAL CANCER RESEARCH
(2023)
Review
Oncology
Qin Liu, Jishi Li, Wai Tong Ng, Anne W. M. Lee
Summary: This review discusses the personalized and intensified treatment strategies for de novo metastatic NPC. Researchers have attempted to define M1 subcategorization to reflect the risk profile and tailor personalized treatment. The multimodality approach incorporating chemotherapy, immunotherapy, locoregional radiation, and ablative treatment to metastatic sites has been shown to improve overall control.
CHINESE CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Chi Leung Chiang, Tai Chung Lam, James Chun Bong Li, Kenneth Sik Kwan Chan, Aya El Helali, Yolanda Yim Ping Lee, Laalaa Hiu Ting Law, Danyang Zheng, Anthony Wing Ip Lo, Ngar Woon Kam, Wing Sum Li, Alice Ka Wai Cheung, James Chung Hang Chow, Sunny Po Chung Chan, Jessica Wing Yu Lai, Sarah Wai Man Lee, Feng-Ming (Spring) Kong, Wai Tong Ng, Dora Lai Wan Kwong, Anne Wing Mui Lee
Summary: This study evaluated the safety and efficacy of bintrafusp alfa in platinum-refractory recurrent or metastatic nasopharyngeal cancer patients. The results showed that bintrafusp alfa demonstrated modest treatment activity, but the high rates of hyper-progressive disease and treatment discontinuation due to treatment-related adverse events are concerning.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Oncology
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T. C. Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K. C. Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L. W. Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard
Summary: This study updated the evaluation of chemotherapy for nasopharynx carcinoma through a network meta-analysis. The results showed that the addition of induction chemotherapy or adjuvant chemotherapy to chemoradiotherapy improved overall survival for patients with non-metastatic nasopharyngeal carcinoma compared to chemoradiotherapy alone.
Review
Oncology
Victor Ho-Fun Lee, Marlinda Adham, Wala Ben Kridis, Paolo Bossi, Ming-Yuan Chen, Imjai Chitapanarux, Vincent Gregoire, Sheng Po Hao, Cheryl Ho, Gwo Fuang Ho, Danita Kannarunimit, Dora Lai-Wan Kwong, Ka-On Lam, Wai Kei Jacky Lam, Quynh-Thu Le, Anne Wing-Mui Lee, Nancy Y. Lee, To-Wai Leung, Lisa Licitra, Darren Wan-Teck Lim, Jin-Ching Lin, Kwok Seng Loh, Pei-Jen Lou, Jean-Pascal Machiels, Hai-Qiang Mai, Ricard Mesia, Wai-Tong Ng, Roger Kai-Cheong Ngan, Joshua K. Tay, Raymond King-Yin Tsang, Chi-Chung Tong, Hung-Ming Wang, Joseph T. Wee
Summary: The COVID-19 pandemic has had a significant impact on the healthcare industry, particularly in the field of otorhinolaryngology. This study provides consensus recommendations on the management of nasopharyngeal carcinoma in the context of the current pandemic and potential future airborne diseases or disasters, with a focus on the use of plasma EBV DNA as a biomarker.
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
