Article
Oncology
Qigen Fang, Yao Wu, Wei Du, Xu Zhang, Defeng Chen
Summary: The expression of PD-L1 in high-grade salivary gland carcinomas was significantly associated with tumor stage, and a tumor proportion score (TPS) of >= 1% was common in 43.1% of patients, with significant differences in 5-year disease-free survival and overall survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Rheumatology
Martha S. van Ginkel, Tineke van der Sluis, Marian L. C. Bulthuis, Henk J. Buikema, Erlin A. Haacke, Suzanne Arends, Stine Harder, Fred K. L. Spijkervet, Hendrika Bootsma, Arjan Vissink, Frans G. M. Kroese, Bert van der Vegt
Summary: Objective digital image analysis (DIA) algorithm can be used to identify lymphoepithelial lesions (LELs) in salivary glands of primary Sjögren's syndrome (pSS) patients. The presence of intraepithelial B-lymphocytes can serve as a clear indicator of pSS and an objective alternative to LEL scoring.
Article
Oncology
Lisa Nachtsheim, M. Mayer, M. F. Meyer, F. Oesterling, H. Kajueter, C. Arolt, A. Quaas, J. P. Klussmann, P. Wolber
Summary: This study provides an overview of the epidemiology of primary salivary gland carcinomas (SGC) based on one of the largest cancer registries in Europe. The study found that the incidence rate of SGC has remained stable over the observed period, and smaller tumors and those without lymph node or distant metastases had a better survival rate.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Muhammet Bekir Hacioglu, Bulent Erdogan, Murat Bardakci, Efnan Algin, Burcu Gulbagci, Ilhan Hacibekiroglu, Jamshid Hamdard, Omer Fatih Olmez, Hadi Akkus, Berna Oksuzoglu, Sema Sezgin Goksu, Shute Ailia Dae, Ahmet Taner Sumbul, Muzaffer Ugrakli, Mustafa Karaagac, Elif Sahin, Devrim Cabuk, Ozden Ozer, Tugba Yavuzsen, Rukiye Arikan, Osman Kostek, Muhammed Mustafa Atci, Abdullah Sakin, Adem Deligonul, Duygu Bayir, Murat Dincer, Oktay Unsal, Ozan Yazici, Esra Zeynelgil, Ahmet Gulmez, Hakan Harputluoglu, Cihan Erol, Mehmet Ali Nahit Sendur, Aydin Aytekin, Baran Akagunduz, Irem Oner, Ozlem Er, Bugra Oztosun, Mahmut Gumus, Fatih Selcuk Biricik, Musa Baris Aykan, Nuri Karadurmus, Ezgi Degerli, Nebi Serkan Demirci, Esma Turkmen, Teoman Sakalar, Saban Secmeler, Ozgur Tanriverdi, Ali Alkan, Yasemin Kemal, Ibrahim Cil, Caglar Unal, Yakup Iriagac, Ozkan Alan, Sevinc Balli, Yuksel Urun, Erkan Ozcan, Nazim Serdar Turhal, Irfan Cicin
Summary: This retrospective-multicenter study includes data from 37 medical oncology clinics from different regions of Turkey, and a total of 443 salivary gland cancers were analyzed. The study shows that distant metastasis is more common in major salivary gland cancers, while locoregional recurrence is more common in minor salivary gland cancers. Epidemiological information, metastasis and recurrence patterns, treatment modalities, and survival analysis of the patients over 20 years of follow-up are presented in this study.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Oncology
Haruto Nishida, Takahiro Kusaba, Kazuhiro Kawamura, Yuzo Oyama, Tsutomu Daa
Summary: We summarize the histopathological characteristics of prognostic factors for salivary gland cancers (SGCs) and discuss the potential diagnostic and treatment targets of genes or molecules. SGCs are diagnosed through histopathological examination, which greatly influences their progression, including metastasis and recurrence. The WHO Classification of Head and Neck Tumors categorizes malignant and benign epithelial tumors into different types. MEC, AdCC, salivary duct carcinoma, salivary carcinoma, NOS, myoepithelial carcinoma, epithelial-myoepithelial carcinoma, and carcinoma ex pleomorphic adenoma are commonly seen types. While some have specific grading systems, a universal grading system has not been recommended for SGCs. On the other hand, cautious treatment is required for PA to prevent metastasis or recurrence.
Review
Medicine, General & Internal
Rui Liao, Hai-Tao Yang, Heng Li, Li-Xiong Liu, Kai Li, Jing-Jing Li, Jie Liang, Xiao-Ping Hong, Yu-Lan Chen, Dong-Zhou Liu
Summary: Sjogren's syndrome is a chronic autoimmune disease with complicated clinical manifestations. Salivary gland biopsy plays a crucial role in diagnosis and risk assessment for the disease.
FRONTIERS IN MEDICINE
(2022)
Article
Otorhinolaryngology
William Tyler Turchan, Mark C. Korpics, Michael Rooney, Matthew Koshy, Michael T. Spiotto
Summary: Metastatic salivary gland cancers, particularly in patients with ACC, exhibit heterogeneous behavior. The anatomic site of metastasis, specifically lung-only metastasis, is shown to be associated with improved survival in this population, which should be considered in future studies aiming to optimize therapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Conor E. Steuer, Glenn J. Hanna, Kartik Viswanathan, James E. Bates, Azeem S. Kaka, Nicole C. Schmitt, Alan L. Ho, Nabil F. Saba
Summary: Salivary gland cancers are rare and histologically diverse tumors that can range from indolent to aggressive, causing significant morbidity and mortality. Surgical resection is the main treatment, but radiation and systemic therapy are also critical. Due to their rarity and heterogeneity, a multidisciplinary approach is best for managing these cancers. This review highlights current standards of care and exciting new research aiming to improve patient outcomes for salivary gland cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Dentistry, Oral Surgery & Medicine
John Lennon Silva Cunha, Silvia Ferreira de Sousa, Carolina Peres Mota, Joao Vitor Rocha Silva, Israel Leal Cavalcante, Erasmo Bernardo Marinho, Ciro Dantas Soares, Ricardo Luiz Cavalcanti de Albuquerque-Junior, Roberta Barroso Cavalcante, Aline Correa Abrahao, Michelle Agostini, Mario Jose Romanach, Bruno Augusto Benevenuto de Andrade, Pablo Agustin Vargas, Oslei Paes de Almeida
Summary: Sialolipoma is a rare histological variant of lipoma that mainly affects the salivary glands, particularly in the parotid gland and palate of female adults. Clinically, it often presents as a slow-growing nodule, and conservative surgical excision is the preferred treatment with low recurrence rates. Pathologists need to recognize sialolipomas to avoid misdiagnoses with other lipomatous tumors that can impact salivary glands.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Malin Tordis Meyer, Christoph Watermann, Thomas Dreyer, Sueleyman Erguen, Srikanth Karnati
Summary: Salivary gland tumors consist of both malignant and benign tumors, with the most common malignant tumors being mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma, and the most common benign tumor being pleomorphic adenoma. Due to their low incidence rates and complex histological patterns, diagnosing salivary gland tumors accurately can be challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Michal Gontarz, Jakub Bargiel, Krzysztof Gasiorowski, Tomasz Marecik, Pawel Szczurowski, Jan Zapala, Grazyna Wyszynska-Pawelec
Summary: This study from a single institution in southern Poland over 26 years provides epidemiological data on primary epithelial salivary gland tumors, showing an increase in incidence rates attributed to benign tumors, particularly in elderly patients with Warthin tumors. Pediatric patients mainly suffered from mucoepidermoid carcinoma.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
Marie Westergaard-Nielsen, Christian Godballe, Jesper Grau Eriksen, Stine Rosenkilde Larsen, Katalin Kiss, Tina Agander, Benedicte Parm Ulhoi, Birgitte Charabi, Tejs Ehlers Klug, Henrik Jacobsen, Jorgen Johansen, Claus Andrup Kristensen, Elo Andersen, Maria Andersen, Simon Andreasen, Kristine Bjorndal
Summary: This study analyzed data of Danish salivary gland carcinoma patients diagnosed from 1990 to 2015, finding that the age-adjusted incidence remained stable and factors such as histological grade significantly impacted survival rates.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Rheumatology
Esther Mossel, Martha S. van Ginkel, Erlin A. Haacke, Suzanne Arends, Silvia C. Liefers, Konstantina Delli, Jolien F. van Nimwegen, Alja J. Stel, Fred K. L. Spijkervet, Arjan Vissink, Bert van der Vegt, Frans G. M. Kroese, Hendrika Bootsma
Summary: The study aimed to understand the relative value of different approaches in assessing salivary gland involvement in pSS. The results showed that histopathology, salivary flow, and ultrasonography assess different constructs of salivary gland involvement and have low correlations. Therefore, these three modalities are complementary and cannot directly replace each other in the diagnosis of pSS.
Review
Medicine, General & Internal
Farzana Chowdhury, Anwar Tappuni, Michele Bombardieri
Summary: Primary Sjogren's syndrome is a chronic autoimmune disease affecting salivary and lachrymal glands, causing dry mouth and eyes symptoms. There is currently no disease-modifying drug approved for treatment, with therapies focused on symptom relief. Management of oral dryness remains a significant unmet clinical need for patients with pSS.
FRONTIERS IN MEDICINE
(2021)
Article
Otorhinolaryngology
Di Zhang, Yuce Wei, Yue Chai, Fei Qi, Mei Dong
Summary: The study aimed to investigate the clinicopathological features and prognosis of postoperative major salivary acinar cell carcinoma (MSACC) and develop a prognostic model. A total of 1398 patients were enrolled from the Surveillance, Epidemiology, and End Results database. Age, marital status, sex, histological grade, T stage, and lymph node status were identified as prognostic factors. A novel nomogram and web calculator were developed for individualized survival prediction and risk stratification. The proposed model provides valuable information for treatment adjustment in high-risk subgroups.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Lisanne V. van Dijk, Abdallah S. R. Mohamed, Sara Ahmed, Nafiul Nipu, G. Elisabeta Marai, Kareem Wahid, Nanna M. Sijtsema, Brandon Gunn, Adam S. Garden, Amy Moreno, Andrew J. Hope, Johannes A. Langendijk, Clifton D. Fuller
Summary: By utilizing "big-data," a personalized radiotherapy prediction model was developed to accurately stratify patients with head and neck cancer into high, intermediate, and low mortality risk groups, providing guidance for personalized radiotherapy.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Andreas Smolders, Adriaan C. Hengeveld, Stefan Both, Robin Wijsman, Johannes A. Langendijk, Damien C. Weber, Anthony J. Lomax, Francesca Albertini, Gabriel Guterres Marmitt
Summary: By reconstructing the delivered treatment, it was found that despite delivery inaccuracies, there is still an expected benefit for proton therapy in lung cancer patients. The choice of deformable image registration algorithm and a/b ratio were assessed for their importance.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kasper Daugaard Larsen, Mads Mose Jensen, Anne-Sophie Homoe, Elisabeth Arndal, Grethe Badsberg Samuelsen, Anders Koch, Xiaohui Chen Nielsen, Preben Homoe, Tobias Todsen
Summary: Nasopharyngeal swabs (NPS) are considered the gold standard for SARS-CoV-2 testing, but alternative specimens such as oropharyngeal swabs (OPS) and nasal swabs may be preferable. However, there is still a lack of strong evidence regarding their diagnostic sensitivity for SARS-CoV-2 testing.
Article
Oncology
David J. Thomson, Clare Cruickshank, Helen Baines, Russell Banner, Matthew Beasley, Guy Betts, Helen Bulbeck, Frances Charlwood, Judith Christian, Matthew Clarke, Olly Donnelly, Bernadette Foran, Callum Gillies, Clare Griffin, Jarrod J. Homer, Johannes A. Langendijk, Lip Wai Lee, James Lester, Matthew Lowe, Andrew McPartlin, Elizabeth Miles, Christopher Nutting, Nachi Palaniappan, Robin Prestwich, James M. Price, Clare Roberts, Justin Roe, Ramkumar Shanmugasundaram, Rita Simoes, Anna Thompson, Catharine West, Lorna Wilson, Jane Wolstenholme, Emma Hall
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
M. Y. Errahmani, M. Locquet, D. Broggio, D. Spoor, G. Jimenez, J. Camilleri, J. A. Langendijk, A. P. G. Crijns, M. O. Bernier, J. Ferrieres, J. Thariat, S. Boveda, Y. Kirova, P. Loap, V Monceau, S. Jacob
Summary: This study assessed the doses of sinoatrial node (SAN) and atrioventricular node (AVN) in breast cancer patients treated with 3D-CRT and evaluated the relevance of large cardiac structures as surrogates. The results showed that right-sided breast cancer patients may have higher AVN doses exceeding 1 Gy, while left-sided breast cancer patients had lower SAN and AVN doses. Among the large cardiac structures, the right atrium may be a meaningful surrogate, especially for left-sided breast cancer patients with inclusion of IMN.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Carl Frederik Haugaard, Simon Andreasen, Patrick R. G. Eriksen, Caroline Olsen, Katalin Kiss, Kristine Bjorndal, Marie Westergaard-Nielsen, Preben Homoe
Summary: This retrospective cohort study examined the histological tumor types, location, incidence, and survival of benign and malignant salivary gland tumors in the Greenlandic Inuit population. The study found that 76% of the tumors were benign, with pleomorphic adenoma being the most common type. Malignant tumors accounted for 24% of the cases, with lymphoepithelial carcinoma being the most common type. The study provides valuable insights into the epidemiology of salivary gland tumors in the Greenlandic Inuit population.
Article
Otorhinolaryngology
Marie Westergaard-Nielsen, Christian Godballe, Jesper Grau Eriksen, Stine Rosenkilde Larsen, Katalin Kiss, Tina Agander, Benedicte Parm Ulhoi, Birgitte Wittenborg Charabi, Tejs Ehlers Klug, Henrik Jacobsen, Jorgen Johansen, Claus Andrup Kristensen, Elo Andersen, Maria Andersen, Kristine Bjorndal
Summary: The aim of this study was to report the incidence, histological subtypes, survival rates, and prognostic factors of salivary gland carcinoma based on a national cohort. All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 were included and analyzed. The study found that the most frequent subtype was adenoid cystic carcinoma and that advanced stage had a negative impact on survival rates.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Ida Grunske Schmidt, Malene Korsholm, Jorgen Johansen, Jens Ahm Sorensen, Christian Godballe, Kristine Bjorndal
Summary: The Danish head and neck cancer fast-track program aims to reduce waiting time and improve survival for patients suspected of cancer. This study found a low frequency of missed cancers in the program, indicating its accuracy and effectiveness.
Article
Oncology
Simon Long Krogh, Carsten Brink, Ebbe Laugaard Lorenzen, Eva Samsoe, Ivan Richter Vogelius, Ruta Zukauskaite, Birgitte Vrou Offersen, Jesper Grau Eriksen, Olfred Hansen, Jorgen Johansen, Agon Olloni, Christina H. Ruhlmann, Lone Hoffmann, Henrik Dahl Nissen, Martin Skovmos Nielsen, Karen Andersen, Cai Grau, Christian Ronn Hansen
Summary: This study reports the development and structure, as well as the functionality and experience, of a national radiotherapy plan database. The system is based on the DICOM-RT standard and allows direct connections to Danish radiotherapy centers. It supports data segregation and collaboration projects, with user access provided through a web interface. The system has been used for data collection, quality assurance, and audit data set generation.
Article
Oncology
Jacob Kinggaard Lilja-Fischer, Morten Horsholt Kristensen, Pernille Lassen, Torben Steiniche, Trine Tramm, Magnus Stougaard, Christian Maare, Jorgen Johansen, Hanne Primdahl, Claus Andrup Kristensen, Maria Andersen, Jesper Grau Eriksen, Jens Overgaard
Summary: This study tested the feasibility of using custom-made HPV next generation sequencing (NGS) panel in oropharyngeal squamous cell carcinoma (OPSCC), and correlated it with p16 immunohistochemistry (IHC). The results showed that HPV DNA testing or typing did not provide additional information in prognostic assessment compared to p16 IHC, which remains the most widely used and accepted prognostic indicator.
Article
Audiology & Speech-Language Pathology
Sabina Storbjerg Houmoller, Li-Tang Tsai, Anne Wolff, Sreeram Kaithali Narayanan, Dan Dupont Hougaard, Michael Gaihede, Dorte Hammershoi, Tobias Neher, Christian Godballe, Jesper Hvass Schmidt
Summary: This study aims to investigate the effects of previous occupational noise exposure in older adults with hearing loss on audiometric configuration, acoustic reflex thresholds, self-reported hearing abilities, and hearing aid effectiveness. The study found that greater occupational noise exposure is associated with a higher prevalence of steeply sloping audiograms and poorer self-reported hearing abilities. There is also a correlation between hearing thresholds and elevated acoustic reflex thresholds.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2023)
Article
Medicine, General & Internal
Christoffer Bing Madsen, Max Rohde, Oke Gerke, Christian Godballe, Jens Ahm Sorensen
Summary: This study investigated the diagnostic accuracy of up-front 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and MRI for detecting cervical lymph node metastases in patients with T1-T2 oral squamous cell carcinoma. The results showed that PET/CT had higher sensitivity but lower specificity compared to neck MRI, and the overall accuracy of both imaging modalities was comparable. Therefore, a combination of PET/CT and MRI should be used for diagnosing cervical lymph node metastases in T1-T2 oral cavity cancer.
Article
Geriatrics & Gerontology
Sabina Storbjerg Houmoller, Anne Wolff, Li-Tang Tsai, Sreeram Kaithali Narayanan, Dan Dupont Hougaard, Michael Lyhne Gaihede, Tobias Neher, Christian Godballe, Jesper Hvass Schmidt
Summary: This study aims to provide clinical guidance for prescribing hearing aids to older adults with presbycusis. The findings suggest that premium hearing aids yield slightly better self-reported hearing abilities compared to basic-feature hearing aids, although the differences are small and statistically significant in only a few outcome variables.
FRONTIERS IN AGING
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
