Article
Oncology
Alvin K. Liu, Jonn Wu, Eric Berthelet, Nafisha Lalani, Nicole Chau, Eric Tran, Sarah Nicole Hamilton
Summary: Brain metastases from head and neck cancer are rare and carry a poor prognosis, with treatment involving intracranial radiotherapy associated with improved survival.
Review
Oncology
Morena Fasano, Ida D'Onofrio, Maria Paola Belfiore, Antonio Angrisani, Valentina Caliendo, Carminia Maria Della Corte, Mario Pirozzi, Sergio Facchini, Marianna Caterino, Cesare Guida, Valerio Nardone, Alfonso Reginelli, Salvatore Cappabianca
Summary: This review discusses the role of clinical management, geriatric evaluation, and therapeutic approaches in elderly patients with head and neck squamous cell carcinoma (HNSCC). Elderly HNSCC patients are often frail with multiple comorbidities and may receive suboptimal treatment. The review summarizes different strategies for the clinical management of elderly HNSCC patients.
Article
Oncology
Gautier Marcq, Luca Afferi, Yann Neuzillet, Timo Nykopp, Charlotte S. Voskuilen, Marc A. Furrer, Wassim Kassouf, Atiqullah Aziz, Anne Sophie Bajeot, Mario Alvarez-Maestro, Peter Black, Morgan Roupret, Aidan P. Noon, Roland Seiler, Kees Hendricksen, Mathieu Roumiguie, Karl H. Pang, Paul Laine-Caroff, Evanguelos Xylinas, Guillaume Ploussard, Marco Moschini, Paul Sargos
Summary: This study investigated the outcomes of muscle-invasive bladder cancer patients with positive surgical margins following radical surgery. It found that half of these patients will experience recurrence within a year and eventually die from the disease. Adjuvant chemotherapy may have a potential role in this patient population, but further clinical trials are needed.
Review
Biochemistry & Molecular Biology
David C. Marcu, Cristian Grava, Loredana G. Marcu
Summary: The latest developments in the management of head and neck cancer involve the use of artificial intelligence and radiomics, particularly delta radiomics, for patient stratification and treatment evaluation. Radiomics enables the extraction of data from imaging modalities to evaluate tumor features and guide treatment decisions. Delta radiomics, which assesses feature variations over time, is shown to have superior value for predicting treatment outcomes and stratifying patients into risk categories. This work aims to review and evaluate the role of delta radiomics in head and neck cancer for tumor response and normal-tissue toxicity predictions, as well as highlight the significance of holomics for comprehensive patient characterization and treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Maria Gebre-Medhin, Eva Brun, Per Engstrom, Hedda Haugen Cange, Lalle Hammarstedt-Nordenvall, Johan Reizenstein, Jan Nyman, Edvard Abel, Signe Friesland, Helena Sjodin, Henrik Carlsson, Karin Soderkvist, Marcus Thomasson, Bjorn Zackrisson, Per Nilsson
Summary: The study demonstrates that for patients with locoregionally advanced HNSCC, cisplatin is superior to cetuximab in terms of locoregional control when used in combination with radiotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Camil Ciprian Mirestean, Cristiana Eugenia Simionescu, Roxana Irina Iancu, Mihai Cosmin Stan, Dragos Petru Teodor Iancu, Florinel Badulescu
Summary: Chondrosarcoma is a rare disease with a relatively good prognosis. In this case, a 30-year-old patient was treated with surgery, chemotherapy, and radiotherapy. Despite the early loss from the oncological record, there was no recurrence of the disease. Treatment decisions should consider tumor size, resection margins, and potential adverse reactions to adjuvant therapy.
Article
Oncology
Yannan Wang, Mengxue Wang, Yan Tang, Bincan Sun, Kai Wang, Feiya Zhu
Summary: The perioperative mortality rate of head and neck cancer was approximately 1%, with causes of death including acute heart failure, rupture of large blood vessels in the neck, and respiratory failure. Risk factors for perioperative mortality included preoperative radiotherapy, previous chemotherapy, hypertension, diabetes, advanced clinical stage, and postoperative infection.
Article
Dentistry, Oral Surgery & Medicine
Zhenlin Dai, Youya He, Xu Zhang, Zhen Tian, Guopei Zhu, Zhenhu Ren, Lulu Ye, Zheqi Liu, Chunyue Ma, Wei Cao, Tong Ji
Summary: This study investigated the clinicopathological features of head and neck dermatofibrosarcoma protuberans (HNDFSP) and identified the expression of clinically relevant indicators. The results showed that HNDFSP is rare and challenging to control locally, with a worse prognosis using current treatment strategies. Wide local excision and long-term follow-up are needed, while radiotherapy may improve the prognosis of patients with HNDFSP.
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Sharon Tzelnick, Aviram Mizrachi, Sagit Stern Shavit, Daniel Ben-Ner, Yonathan Reuven, Bshara Elias, Thomas Shpitzer, Gideon Bachar
Summary: The study found that elderly cancer patients undergoing major head and neck surgeries have higher complication rates compared to younger patients, but the difference is not significant. Elderly patients have lower postoperative complication and survival rates.
Article
Cell Biology
Yuanyuan Liu, Xing Wang, Yuying Liu, Jianqiang Yang, Wei Mao, Chen Feng, Xiaoliang Wu, Xinwei Chen, Lixiao Chen, Pin Dong
Summary: NAT10 promotes lymph node metastasis in HNSCC by stabilizing the GLMP transcript through ac4C modification. Inhibition of NAT10 may serve as a therapeutic strategy for HNSCC.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Jing Wei, Hui Deng, Lihua Wu, Jianbo Song, Junping Zhang, Wenhui Yang, Mengxian Zhang, Hongtao Zhen
Summary: This study aimed to explore the epidemiological characteristics and prognostic factors of head and neck lymphoepithelial carcinoma (LEC). A retrospective cohort study was conducted using data from the Surveillance, Epidemiology and End Results database. Kaplan-Meier survival analysis and Cox regression models were used to assess overall survival (OS) and cancer-specific survival (CSS). Nomograms were established to predict OS and CSS in patients with nasopharyngeal LEC, and the effects of treatment were compared using the restricted mean survival time (RMST). The results showed that head and neck LEC had a favorable prognosis, and radiotherapy played a significant role in managing nasopharyngeal LEC patients influenced by multiple prognostic factors.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Review
Oncology
Miguel Reis Ferreira, Anna Pasto, Tony Ng, Vinod Patel, Teresa Guerrero Urbano, Cynthia Sears, William G. Wade
Summary: This article focuses on how microbiota research can contribute to the improvement of radiotherapy for head and neck squamous cell carcinoma (HN-SCC), specifically discussing its relevance to human physiology, its interactions with HN-SCC, and the potential use of microbiota as predictive and prognostic biomarkers. The article also discusses the potential of leveraging the microbiota and its interactions with immunity to improve treatment results, drawing parallels with other cancers where research is more advanced. The authors map out future directions of research and explain clinical implications in detail.
CANCER TREATMENT REVIEWS
(2022)
Article
Oncology
Wenli Liu, Aiham Qdaisat, Renata Ferrarotto, Clifton D. Fuller, Ming Guo, Larissa A. Meyer, Santhosshi Narayanan, Gabriel Lopez, Lorenzo Cohen, Eduardo Bruera, Ehab Y. Hanna, Sai-Ching J. Yeung
Summary: This study examined the association between hypomagnesemia and survival in patients with head and neck cancer receiving concurrent chemoradiation with cisplatin and/or carboplatin. It was found that higher frequency and severity of hypomagnesemia during treatment were significantly associated with shorter survival, independent of other known prognostic factors. Further prospective studies are necessary to investigate the impact of preventing hypomagnesemia on survival in this patient population.
Article
Oncology
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Summary: A retrospective analysis of 447 patients with HNSCC revealed that HPV negativity, high neutrophil/lymphocyte ratio, disease-free interval ≤6 months, and poor performance status were predictors of worse survival. Furthermore, the majority of recurrences and metastases occurred within 6 months to 2 years after treatment completion.
Article
Otorhinolaryngology
M. Lundberg, A. Haapaniemi, J. Hagstrom, S. Juteau, M. Hernberg, A. A. Makitie, S. Vento
Article
Otorhinolaryngology
S. Sainio, K. Blomgren, M. Lundberg
Article
Oncology
Timo Carpen, Stina Syrjanen, Lauri Jouhi, Reija Randen-Brady, Caj Haglund, Antti Makitie, Petri S. Mattila, Jaana Hagstrom
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Otorhinolaryngology
Anni Koskinen, Marie Lundberg, Markus Lilja, Jyri Myller, Matti Penttilae, Heini Huhtala, John M. Lee, Karin Blomgren, Sanna Toppila-Salmi
Summary: This study aimed to compare the need for revision surgery, long-term efficacy, and satisfaction in chronic rhinosinusitis patients who had undergone maxillary sinus operation with either balloon sinuplasty or traditional endoscopic sinus surgery (ESS) technique. The results showed that although the patient groups expressed equal satisfaction and change in symptoms after the operations, the need for revision surgery was higher after balloon sinuplasty than after ESS.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Article
Otorhinolaryngology
Lena Hafren, Riitta Saarinen, Marie Lundberg
Summary: This study investigated the impact of the lockdown during the COVID-19 pandemic on the incidence of Bell's palsy and SSNHL. The results showed a decrease in the incidence of Bell's palsy during the pandemic, while no significant change was observed in the incidence of SSNHL. This suggests a possible association between Bell's palsy and transmittable respiratory tract pathogens.
ACTA OTO-LARYNGOLOGICA
(2022)
Article
Otorhinolaryngology
Marie Lundberg, Markus Lilja, Karin Blomgren, Ida Kotisalmi, Antti A. Makitie, Sara Sainio, Maija Hytonen
Summary: Preoperative antibiotic prophylaxis effectively reduced postoperative infection rate after septoplasty, while postoperative antibiotics alone showed no significant effect. One dose of intravenous cefuroxime before incision was the most effective preventive measure, and local anesthesia also reduced the risk of SSI.
CLINICAL OTOLARYNGOLOGY
(2022)
Article
Allergy
Raffi Tchekmedyian, Marie Lundberg, Kathleen M. Buchheit, Rie Maurer, Deborah Gakpo, Jyotsna Mullur, Jillian C. Bensko, Tanya M. Laidlaw
Summary: Anosmia and hyposmia severely impact the physical, emotional, and mental health of patients with aspirin-exacerbated respiratory disease (AERD), leading to safety concerns in their daily lives.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Otorhinolaryngology
Sara Sainio, Marie Lundberg, Sari Hammaren-Malmi, Petra Pietarinen, Karin Blomgren
Summary: This study aimed to investigate the effect of the Alar Nasal Valve Stent on nasal breathing in patients with lateral nasal wall insufficiency. The results showed a significant subjective improvement in nasal breathing after the surgery, but no difference in objective symptom measurements was observed.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Allergy
Annina Lyly, Emma Genberg, Paula Kauppi, Paula Virkkula, Stella E. Lee, Tanya M. Laidlaw, Sanna Toppila-Salmi, Marie Lundberg
Summary: This retrospective study evaluated the effects of biologics on asthma patients with concomitant CRS. The use of anti-IgE and/or anti-IL-5/5R biologics reduced the need for oral corticosteroids medication and improved nasal polyp score and sinonasal outcome test scores. However, the discontinuation rate of biologic therapy was high.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Review
Surgery
J. Hellgren, M. Lundberg, N. Rubek, C. von Buchwald, S. Steinsvag, A. Makitie
Summary: This review of studies from the Nordic countries over the past decade shows that septoplasty is effective in relieving nasal obstruction. However, the lack of standardization in patient selection, surgical methods, and follow-up procedures leads to a 25% failure rate in septoplasty surgery.
FRONTIERS IN SURGERY
(2022)
Editorial Material
Otorhinolaryngology
Simon Chiang, Sophie E. E. Yu, Tejas S. Athni, Regan W. Bergmark, Alice Z. Maxfield, Rachel E. Roditi, Kathleen M. Buchheit, Marie Lundberg, Margaret B. Mitchell, Stella E. E. Lee
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Allergy
Pinja Ilmarinen, Anna Julkunen-Iivari, Lic Odont, Marie Lundberg, Annika Luukkainen, Mikko Nuutinen, Jussi Karjalainen, Heini Huhtala, Juha Pekkanen, Hannu Kankaanranta, Sanna Toppila-Salmi
Summary: This study conducted a phenotypic clustering analysis of adult-onset asthma in Finland, identifying two clusters with early and late onset, and found partial overlap with clusters identified in clinical settings. These results are important for a better understanding of adult-onset asthma phenotypes and support personalized management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Otorhinolaryngology
Sara Sainio, Karin Blomgren, Anu Laulajainen-Hongisto, Marie Lundberg
Summary: This study aimed to assess the long-term effectiveness of one KOS treatment for NAR patients. The results showed that KOS treatment significantly improved the symptoms and nasal airflow of patients for at least 1 year, potentially reducing the need for invasive treatments.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Sara Sainio, Karin Blomgren, Anni Koskinen, Marie Lundberg
Summary: This study aimed to explore the predictive factors of postoperative outcome of frontal sinus balloon dilation through a retrospective questionnaire study. It was found that previous sinonasal surgery predicted a higher revision rate, and the hybrid surgery group had significantly fewer reoperations compared to the balloon only group.
Review
Allergy
Annina Lyly, Tanya M. Laidlaw, Marie Lundberg
Summary: The pathomechanisms of NSAID-exacerbated respiratory disease are complex and involve genetic predisposition, environmental triggers, dysregulation of fatty acid and lipid metabolism, altered cellular interactions, and chronic inflammation in the respiratory track. Understanding the background of this illness is crucial as it significantly impacts patients' lives.
FRONTIERS IN ALLERGY
(2021)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
