Review
Chemistry, Physical
Changrong Shi, Zijian Zhou, Hongyu Lin, Jinhao Gao
Summary: This review focuses on the current development of advanced imaging technologies aiming to predict the treatment response in cancer therapy, with special interest in systems that provide rapid and noninvasive assessment of pharmacokinetics and tumor microenvironment. It also provides an overview of the emerging artificial intelligence technology and machine learning in medical imaging applications, discussing the current status, practical significance, and future challenges. Ultimately, the authors hope that this review will inspire research interest in molecular imaging and precision medicine.
Review
Dentistry, Oral Surgery & Medicine
Jasper Vonk, Jaron Gerard de Wit, Floris Jan Voskuil, Max Johannes Hendrikus Witjes
Summary: Early diagnosis and aggressive surgical excision are crucial for optimal treatment outcomes in oral squamous cell carcinomas. However, current diagnostic tools and intraoperative assessment methods are limited, leading to late-stage detection of oral cancer.
Article
Oncology
Armando De Virgilio, Raul Pellini, Giovanni Cammaroto, Rossella Sgarzani, Andrea De Vito, Manlio Gessaroli, Andrea Costantino, Gerardo Petruzzi, Bianca Maria Festa, Flaminia Campo, Claudio Moretti, Barbara Pichi, Giuseppe Mercante, Giuseppe Spriano, Claudio Vicini, Giuseppe Meccariello
Summary: This study retrospectively evaluated the clinical and pathological characteristics, treatment details, and oncological outcomes of 139 patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with Trans Oral Robotic Surgery (TORS). The results showed that TORS is a safe and effective treatment option with good oncological outcomes.
Article
Medicine, General & Internal
Agnieszka Krolikowska, Karolina Filipska-Blejder, Renata Jablonska, Beata Haor, Anna Antczak-Komoterska, Monika Biercewicz, Lech Grzelak, Marek Harat, Robert Slusarz
Summary: The aim of this study was to evaluate the quality of life after surgical treatment of brain tumors. The results showed that the greatest reduction in quality of life after surgery was observed in patients with low-grade glial tumors and extracerebral tumors, while after 30 days, there was an improvement in quality of life for all patients. The histopathological diagnosis of different tumor types had an impact on patients' quality of life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Sander Ubels, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan Willem Haveman, Joos Heisterkamp, Grard Nieuwenhuijzen, Fatih Polat, Jeroen Schouten, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: This retrospective cohort study aimed to assess the effectiveness of different treatment strategies for anastomotic leak after oesophagectomy. The study found that less invasive primary treatment resulted in fewer complications. Therefore, less invasive primary treatment may lead to better clinical outcomes, but further studies are needed to confirm these findings.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Victoria Huynh, Kathryn Colborn, Shelby Smith, Levi N. Bonnell, Gretchen Ahrendt, Nicole Christian, Simon Kim, Dan D. Matlock, Clara Lee, Sarah E. Tevis
Summary: This study aimed to compare longitudinal patient-reported outcomes between breast cancer patients undergoing lumpectomy and mastectomy, finding that mastectomy patients experienced significantly greater decreases in breast satisfaction, psychosocial well-being, and sexual well-being over time compared with lumpectomy patients, with lumpectomy patients more likely to return to baseline scores at 3 and 6 months postoperatively. Understanding these differences can inform early intervention strategies to prevent long-term morbidities.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ravindri Jayasinghe, Ashan Fernando, Umesh Jayarajah, Sanjeewa Seneviratne
Summary: This study evaluated the post-treatment quality of life in Sri Lankan breast cancer patients and found that factors such as sexual functioning, breast and arm symptoms, and hair loss contributed to a poorer quality of life, while the impact on overall health status was minimal. The type of surgery did not seem to be significantly associated with quality of life. Further studies with larger sample sizes are needed to explore these factors in more depth.
Article
Dentistry, Oral Surgery & Medicine
Anne-Susann Bachmann, Joerg Wiltfang, Katrin Hertrampf
Summary: This study adapted the Speech Handicap Index (SHI) to German and compared it to the German Voice-Handicap-Index (VHI) in assessing the quality of life for oral cancer patients with posttreatment speech difficulties. The results showed that the SHI reliably assessed speech intelligibility and articulation-related quality of life, with a significantly greater responsiveness compared to the VHI in capturing experienced handicap in speech impairments.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Medicine, General & Internal
Maria Lavdaniti, Ioannis Tilaveridis, Dimitra Palitzika, Athanasios Kyrgidis, Stefanos Triaridis, Konstantinos Vachtsevanos, Angeliki Kosintzi, Konstantinos Antoniades
Summary: This study assessed the quality of life of oral cancer patients after surgical therapy and identified factors affecting it. The location of the tumor was found to impact social contact and nutritional supplements. Patients' quality of life deteriorated immediately after treatment but significantly improved over time.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ankit Maheshwari, Partha Sarathi Patra, Sukanta Ray, G. K. Dhali, Kshaunish Das
Summary: This study validated the effectiveness of COPPS in a geographically diverse patient population, demonstrating a positive correlation between COPPS severity and number of hospitalisations and days spent in hospital.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Surgery
D. Peter O'Leary, Siun M. Walsh, Jarlath Bolger, Chwanrow Baban, Hilary Humphreys, Sorcha O'Grady, Aisling Hegarty, Aoife M. Lee, Mark Sheehan, Jack Alderson, Ruth Dunne, Martina M. Morrin, Michael J. Lee, Colm Power, Deborah McNamara, Niamh McCawley, Will Robb, John Burke, Jan Sorensen, Arnold D. Hill
Summary: The evaluation of conservative treatment for acute uncomplicated appendicitis showed higher recurrence rates and inferior quality of life in the antibiotics-only group, despite lower total costs. Surgery remains the mainstay of treatment for this common acute surgical condition.
Editorial Material
Medicine, General & Internal
Christobel M. Saunders, Lesley Stafford, Martha Hickey
Summary: Breast cancer has significant physical and psychological effects, and guidelines and care models are available to alleviate these effects.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Orthopedics
Lisa M. J. Esteban Lopez, Lisa Hoogendam, Guus M. Vermeulen, Jonathan Tsehaie, Harm P. Slijper, Ruud W. Selles, Robbert M. Wouters
Summary: In the nonsurgical treatment of thumb carpometacarpal (CMC-1) osteoarthritis (OA), pain and limitations in activities of daily living (ADL) did not worsen after 12 months of follow-up. Patient satisfaction with treatment results was high, supporting the sustainability of nonsurgical treatment.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Health Care Sciences & Services
Philipp Jehn, Philippe Korn, Nils-Claudius Gellrich, Alexander-Nicolai Zeller, Michael-Tobias Neuhaus, Frank Tavassol, Ruediger Zimmerer, Gertrud Krueskemper, Simon Spalthoff
Summary: This study found that many oral cancer patients lack information about the potential physical and psychological consequences of surgery, and that this lack of information is significantly correlated with increased perception of posttherapeutic disorders. Patients' quality of life may benefit from having their information needs adequately fulfilled during the diagnosis and treatment of oral cancer.
QUALITY OF LIFE RESEARCH
(2021)
Article
Oncology
Atilla Soran, Aykut Soyder, Serdar Ozbas, Vahit Ozmen, Hasan Karanlik, Abdullah Igci, Mahmut Muslumanoglu, Turkkan Evrensel, Zafer Canturk, Zafer Utkan, Cihangir Ozaslan, Cihan Uras, Umit Ugurlu, Cavit Col, Neslihan Cabioglu, Ali Uzunkoy, Bahadir M. Gulluoglu, Ergun Erdem, Can Konca, Efe Sezgin
Summary: This study evaluated the long-term quality of life in de novo stage IV breast cancer patients who received either loco-regional treatment (LRT) and systemic treatment (ST) or ST alone. The study found that patients who had LRT had similar physical and mental health outcomes compared to those who received ST only after living for more than 3 years. Additionally, the quality of life in de novo stage IV BC patients was found to be worse compared to stage I-III BC patients.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Carlos Llorens, Beatriz Soriano, Lucia Trilla-Fuertes, Leticia Bagan, Ricardo Ramos-Ruiz, Angelo Gamez-Pozo, Cristina Pena, Jose V. Bagan
Summary: By using RNAseq technology to explore the pathophysiology of proliferative verrucous leukoplakia, differences in gene expression related to immune surveillance and cancer biomarkers were identified, providing a possible explanation for malignant transformation in some cases.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Saman Warnakulasuriya, Omar Kujan, Jose M. Aguirre-Urizar, Jose Bagan, Miguel Angel Gonzalez-Moles, Alexander R. Kerr, Giovanni Lodi, Fernanda Weber Mello, Luis Monteiro, Graham R. Ogden, Philip Sloan, Newell W. Johnson
Summary: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of oral cancer, and an expert group updated the nomenclature and classification of OPMDs, adding oral lichenoid lesions and oral manifestations of 'chronic graft-versus-host disease' to the list. It is recommended to establish a global research consortium to study the natural history of OPMDs based on the proposed classification.
Review
Dentistry, Oral Surgery & Medicine
Juan Seoane, Saman Warnakulasuriya, Jose Vicente Bagan, Jose Manuel Aguirre-Urizar, Pia Lopez-Jornet, Gonzalo Hernandez-Vallejo, Miguel Angel Gonzalez-Moles, Manuel Pereiro-Ferreiros, Javier Seoane-Romero, Pablo Varela-Centelles
Summary: This study discussed the terminology and classification of actinic cheilitis (AC) and reached a consensus on its diagnostic and therapeutic approaches. Experts agreed on the terminology, classification, diagnosis, and treatment of AC, but highlighted a lack of agreement on diagnostic criteria and procedures.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Alex Proano-Haro, Leticia Bagan, Jose Bagan
Summary: A systematic review and meta-analysis on the incidence of recurrences in patients with Proliferative Verrucous Leukoplakia (PVL) found that different treatment strategies have limited impact on reducing the recurrence rate of PVL, with insufficient scientific evidence to support any specific treatment approach.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Miguel angel Gonzalez-Moles, Fernanda Weber Mello, Jose V. Bagan, Saman Warnakulasuriya
Summary: This study investigated the malignant transformation of oral proliferative verrucous leukoplakia, finding that females and gingiva were more commonly affected. The pooled proportion of malignant transformation was 43.87%, with conventional squamous cell carcinoma being the most frequent histopathological subtype. No conclusive results were found between malignant transformation and sex, age, tobacco, or alcohol consumption.
Article
Dentistry, Oral Surgery & Medicine
Monica Pentenero, Samuele Sutera, Giovanni Lodi, Jose V. Bagan, Camile S. Farah
Summary: Oral Medicine is a young dental specialty that deals with orofacial conditions not directly related to common tooth pathologies like dental caries or periodontal diseases. Survey data from practitioners in Europe and Australia show that clinical practice in Oral Medicine commonly involves immune-mediated disorders, potentially malignant disorders, oral mucosal infections, and chronic pain disorders, with geographical variabilities.
Article
Oncology
Alejandro Herreros-Pomares, Carlos Llorens, Beatriz Soriano, Leticia Bagan, Andrea Moreno, Silvia Calabuig-Farinas, Eloisa Jantus-Lewintre, Jose Bagan
Summary: Through integrated analysis of MeDIP-seq and RNAseq data, hypermethylation patterns were found in PVL patients, aligning with the deregulation status observed in OSCC patients compared to normal tissue. This study suggests potential diagnostic biomarkers for PVL and OSCC, indicating the promise of novel epigenetic-based therapies.
Article
Medicine, General & Internal
Valentina Dikova, Eloisa Jantus-Lewintre, Jose Bagan
Summary: This study investigated the levels of certain salivary cytokines as potential biomarkers for distinguishing between oral squamous cell carcinoma (OSCC), oral leukoplakia (OL), and healthy individuals. The findings suggest that IL-6, IL-8, TNF-alpha, HCC-1, and PF-4 in saliva may be useful in differentiating between these conditions, with IL-6 and TNF-alpha potentially indicating the progression of OSCC, especially in the presence of neck metastases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sara Principe, Enrique Zapater-Latorre, Leo Arribas, Enrique Garcia-Miragall, Jose Bagan
Summary: The study analyzed salivary cytokines in head and neck cancer patients before and after radiotherapy, finding significant increases in IL-8 and MCP-1 post-treatment. IL-8 was identified as a potential predictive biomarker for positive outcomes in radiotherapy.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alejandro Lorenzo-Pouso, Susana B. Bravo, Javier Carballo, Maria del Pilar Chantada-Vazquez, Jose Bagan, Leticia Bagan, Cintia M. Chamorro-Petronacci, Mercedes Conde-Amboage, Rafael Lopez-Lopez, Abel Garcia-Garcia, Mario Perez-Sayans
Summary: This study investigated the salivary proteome in MRONJ patients and identified differentially expressed proteins. Three prioritized proteins were identified, which may serve as a potential biomarker panel for the prediction or diagnosis of MRONJ.
Article
Dentistry, Oral Surgery & Medicine
Monica Pentenero, Samuele Sutera, Giovanni Lodi, Jose Bagan, Camile S. Farah
Summary: This report investigates the attitudes and practices of Oral Medicine Practitioners (OMPs) in the diagnosis, risk stratification, and treatment of oral leukoplakia (OL). Lack of consensus in the management of OL was observed, indicating a need for treatment guidelines to reduce variability among practitioners.
Article
Oncology
Antonio Ferrer-Sanchez, Jose Bagan, Joan Vila-Frances, Rafael Magdalena-Benedito, Leticia Bagan-Debon
Summary: Using deep learning, this study developed a model to predict the probability of malignancy and high-risk dysplasia in oral leukoplakia lesions. The model achieved high sensitivity and specificity in predicting malignant transformation and high-risk dysplasia, and the generated heatmap provided interpretability of the model's output.
Article
Biochemistry & Molecular Biology
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Eloisa Jantus-Lewintre, Concepcion Gimeno-Cardona, Jose Bagan
Summary: This study aims to compare and describe the composition and diversity of the oral microbiome in patients with homogeneous leucoplakia, proliferative verrucous leukoplakia, oral squamous cell carcinoma, and OSCC preceded by PVL. The number of bacterial species was lower in cancer patients, with Fusobacteriota being the dominant group. PVL and PVL-OSCC patients had a higher abundance of Campilobacterota and lower Proteobacteria compared to other groups. This is the first study comparing oral microbiome alterations in these groups, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Alex Proano, Diana Garcia, Juan Sandoval, Jose Bagan
Summary: This study investigated the pathophysiologic differences between proliferative verrucous leukoplakia-associated oral squamous cell carcinoma (PVL-OSCC) and non-PVL-OSCC through transcriptomic and DNA methylation analyses. The results showed that PVL-OSCC patients had lower expression of cancer-related genes and hypermethylation of the promoter region of many genes, suggesting that DNA methylation could be a regulatory mechanism.
Article
Dentistry, Oral Surgery & Medicine
Jose Bagan, Miguel Martorell, Jose L. Cebrian, Andrea Rubert, Leticia Bagan, Carlos Mezquida, David Hervas
Summary: This study analyzed the differences in cancer development among patients with oral leukoplakia and identified certain factors that increased the risk of malignant transformation. The histology type and tongue location were found to be associated with an increased risk of developing cancer.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
