Journal
ORAL ONCOLOGY
Volume 45, Issue 2, Pages 103-108Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2008.03.008
Keywords
Ameloblastoma; Odontogenic tumor; beta-Catenin; APC; Mutation; Wnt
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Funding
- Ministry of Education, Science and Culture of Japan
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The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC (adenomatous polyposis coli), beta-catenin and Axin are frequently mutated in some primary human cancers. This study was conducted to clarify the relation of beta-catenin accumulation and the mutation of the CTNNB1 (beta-catenin) gene with the mutation of APC gene in the process of development of odontogenic tumors including ameloblastoma and odontogenic carcinoma (OC). beta-Catenin accumulation was examined by immunohistochemistry in formalin-fixed, paraffin-embedded samples of six ameloblastomas and eight OCs. We also performed a mutation analysis of CTNNB1 and APC to examine the cause of P-catenin accumulation. All, ameloblastoma cases and six out of eight (75%) OC cases exhibited beta-catenin accumulation in the nucleus. CTNNB1 mutation was only found in one OC case, whereas three of six (50%) amelobtastoma cases and two out of eight (25%) OC cases had APC mutations within the mutational cluster region. Our findings suggest that aberrant beta-catenin expression and APC missense mutation may play an important role for the pathogenesis of epithelial odontogenic tumors. (C) 2008 Elsevier Ltd. All rights reserved.
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