Article
Genetics & Heredity
Huichao Huang, Ying Fu, Yankun Duan, Ye Zhang, Miaolong Lu, Zhuchu Chen, Maoyu Li, Yongheng Chen
Summary: This study investigates the profiles of global proteome, acetylome, and phosphoproteome in 5-8 F cells upon SAHA induction, and explores the crosstalk between these data sets. The results demonstrate the interconnectivity of acetylation and phosphorylation signaling networks, and suggest that SAHA-mediated HDAC inhibition may alter acetylation and phosphorylation of viral proteins, leading to reprogramming of cellular signaling pathways and anti-tumor effects in NPC cells.
FRONTIERS IN GENETICS
(2022)
Article
Virology
Zhongshun Liu, Baoqin Xuan, Shubing Tang, Zhikang Qian
Summary: SAHA, an effective anticancer drug, also shows inhibitory effects on many viruses, including HCMV. It has been found that SAHA significantly suppresses HCMV replication by affecting gene transcription, interferon-mediated immune responses, and FABP4 protein expression. This suggests that FABP4 may contribute to the inhibitory effect of SAHA on HCMV replication.
Article
Biochemistry & Molecular Biology
Merve Ozel, Gulden Baskol, Mevlut Baskol, Fatma Gunes, Cigdem Ucar, Busra Nur Dogru, Hilal Akalin
Summary: The study found that SAHA can reduce the cell viability of cholangiocarcinoma cell line and arrest cells in the G0/G1 phase. However, SAHA also increases the expression levels of certain proteins and genes, which may contribute to drug resistance in the cells. Therefore, caution should be exercised when using SAHA for CCA treatment.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hye In Kim, Seok Kyo Seo, Seung Joo Chon, Ga Hee Kim, Inha Lee, Bo Hyon Yun
Summary: SAHA induces apoptosis in human endometrial cells by modulating the TRX/TBP-2 system, showing potential as a therapeutic agent for endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Pantu Kumar Roy, Angela Ji-Won Ha, Shamsun Nahar, Md. Iqbal Hossain, Md. Ashrafudoulla, Sazzad Hossen Toushik, Md. Furkanur Rahaman Mizan, Iksoon Kang, Sang-Do Ha
Summary: This study determined the formation of biofilms by Salmonella Kentucky on different surfaces and found that the histone deacetylase inhibitor-vorinostat (SAHA) could inhibit biofilm formation by downregulating the expression of virulence and quorum-sensing genes. The findings suggest that SAHA has potential as an anti-biofilm agent in the food industry.
Article
Biochemistry & Molecular Biology
Guilherme Freimann Wermelinger, Lucas Rubini, Anna Carolina Carvalho da Fonseca, Gabriel Ouverney, Rafael P. R. F. de Oliveira, Acacio S. de Souza, Luana S. M. Forezi, Gabriel Limaverde-Sousa, Sergio Pinheiro, Bruno Kaufmann Robbs
Summary: Oral squamous cell carcinoma (OSCC) is the majority of oral cancers and the eighth most common cancer in men. Current chemotherapeutics have significant side effects, necessitating the development of new anti-cancer agents. In this study, new 1,2,3-triazole-chalcone hybrids were synthesized and evaluated against OSCC, showing great cytotoxicity and selectivity. The compound 1f was found to induce apoptosis and cell cycle arrest, and it also showed potential affinity for the MDM2 protein. Overall, 1f is a promising lead for a new chemotherapeutic drug against OSCC and possibly other types of cancers.
Article
Biochemistry & Molecular Biology
Isabel de Pedro, Jesus Galan-Vidal, Ana Freije, Ernesto de Diego, Alberto Gandarillas
Summary: p21 plays a crucial role in driving keratinocytes towards differentiation in response to genomic stress by intervening in the mitosis block. Loss of p21 allows cells to escape differentiation and continue proliferation, while also driving keratinocytes from differentiation to apoptosis.
Review
Oncology
Anna Wawruszak, Lidia Borkiewicz, Estera Okon, Wirginia Kukula-Koch, Syeda Afshan, Marta Halasa
Summary: Breast cancer remains a challenging malignancy with varying responses to therapy, requiring the development of new active agents to improve the current treatment regimens. Vorinostat (SAHA) shows promise in the therapy of different histological subtypes of breast cancer, either alone or in combination with other anticancer agents, based on preclinical and clinical trials data.
Article
Chemistry, Medicinal
Sameh M. Elsibaei, Asma Amleh, Mohamed A. Ismail, Wael M. El-Sayed
Summary: The current study tested the antiproliferative activity of three azafuramidines against different human cell lines and explored their molecular mechanisms. The azafuramidines demonstrated potent cytotoxicity, selectivity, and the ability to prevent metastasis. They also arrested cell cycles and increased apoptosis. The chlorophenyl derivatives could potentially act as anticancer agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Medicine, Research & Experimental
Kan Wu, Xueqin Chen, Xufeng Chen, Shirong Zhang, Yasi Xu, Bing Xia, Shenglin Ma
Summary: The study found that SAHA induced radiosensitization in H1299 cells expressing wild-type p53, p53(R175H) or p53(P223L). However, this effect was not observed in parental H1299 (p53-null) cells or cells expressing p53 with certain mutations. Mitochondrial apoptosis was induced in SAHA-sensitized cells following irradiation, and a secondary mutation at K120 could eliminate the radiosensitization effect.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Krimo Toutah, Nabanita Nawar, Sanna Timonen, Helena Sorger, Yasir S. Raouf, Shazreh Bukhari, Jana von Jan, Aleksandr Ianevski, Justyna M. Gawel, Olasunkanmi O. Olaoye, Mulu Geletu, Ayah Abdeldayem, Johan Israelian, Tudor B. Radu, Abootaleb Sedighi, Muzaffar N. Bhatti, Muhammad Murtaza Hassan, Pimyupa Manaswiyoungkul, Andrew E. Shouksmith, Heidi A. Neubauer, Elvin D. de Araujo, Tero Aittokallio, Oliver H. Kraemer, Richard Moriggl, Satu Mustjoki, Marco Herling, Patrick T. Gunning
Summary: Epigenetic targeting, especially with HDAC inhibitors like KT-531, has shown promising efficacy in treating hematological cancers. In the case of T-cell prolymphocytic leukemia (T-PLL), overexpression of HDAC6 has been identified as a target for therapy, with KT-531 demonstrating strong inhibitory potency and safety in preclinical studies. Combination studies with approved cancer drugs have shown synergistic effects, indicating the potential for durable remission in T-PLL patients.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Jia-Yao Li, Tian Tian, Bing Han, Ting Yang, Yi-Xin Guo, Jia-Yu Wu, Yu-Si Chen, Qin Yang, Ru-Jia Xie
Summary: SAHA stimulates FAM134B-mediated ER-phagy to enhance the mitochondrial apoptotic pathway, thereby promoting HCC cell death.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ann-Kathrin Schmidt, Karoline Pudelko, Jan-Eric Boekenkamp, Katharina Berger, Maik Kschischo, Holger Bastians
Summary: Whole chromosome instability is a hallmark of human cancer and can be induced by abnormal microtubule assembly rates during mitosis, triggering errors in chromosome segregation. Loss of tumor suppressor genes can lead to increased mitotic microtubule assembly rates and contribute to chromosome instability in cancer cells.
Article
Multidisciplinary Sciences
Yuta Shinohara, Jumpei Washio, Yuri Kobayashi, Yuki Abiko, Keiichi Sasaki, Nobuhiro Takahashi
Summary: This study investigated the effects of oxygen concentration fluctuations on the glucose metabolism of oral squamous cell carcinoma and normal epithelial cells. It was found that rapid increases in oxygen levels significantly enhanced the metabolic activity of hypoxically cultured cancer cells, while normal cells did not respond to the changes in oxygen levels.
Article
Cardiac & Cardiovascular Systems
Kaihao Wang, Ruijie Tang, Siyuan Wang, Wenyao Wang, Kuo Zhang, Jun Li, Ping Li, Yi-Da Tang
Summary: The study demonstrated that SAHA has anti-fibrotic effects in MI-induced cardiac fibrosis by suppressing the TGF beta/P38 pathway and inhibiting cardiac fibroblasts proliferation induced by TGF-beta 1. SAHA may exert its anti-fibrotic effect through promoting DUSP4 expression and inhibiting TGF-beta 1-induced P38 phosphorylation in cardiac fibroblasts. These findings suggest that SAHA could be a promising treatment for MI-induced cardiac fibrosis.
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
