Article
Biochemistry & Molecular Biology
Yuhang Liu, Anwei Zhou, Yiping Zhang, Zihan Tian, Xiao Cheng, Ya Gao, Xinyuan Zhou, Xiaotong Wu, Kerong Chen, Xinghai Ning
Summary: A photoactive self-healing hydrogel called Macropatch has been developed to promote wound healing by protecting the wound from further injury, sealing organ bleeding, and preventing bacterial infections under visible light irradiation. The hydrogel exhibits good self-healing capability, mechanical strength, tissue adhesiveness, and visible light-induced antibacterial activity, leading to a fast recovery of bacteria-infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Cell Biology
Matthew Hunt, Monica Torres, Etty Bachar-Wikstrom, Jakob D. Wikstrom
Summary: Mitochondria play a critical role in wound healing and chronic wound pathogenesis through various mechanisms such as metabolism, apoptosis, and redox signaling. However, most studies have used animal models instead of patient tissue, highlighting a need for more research using human samples.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Jace Ming Xuan Chia, Zack Zhong Sheng Goh, Zi Yang Chua, Kennedy Yao Yi Ng, Diana Ishak, Si Ming Fung, Joanne Yuen Yie Ngeow, Konstadina Griva
Summary: During the COVID-19 outbreak, cancer patients and caregivers face heightened vulnerability and anxiety. They primarily focus on heightened threat perception, impact on healthcare experience, sense of responsibility, striving for normalcy, and feelings of safety and trust.
Article
Polymer Science
Yali Zhao, Jiayue Chen, BingXi Wang, Li Wei
Summary: In this study, multifunctional mussel-inspired hydrogels CACS-Fe3+-CYCS and CACS-Fe3+ were prepared, which can provide a moist environment, close adhesion, and self-healing and antibacterial properties for the repair of infectious wounds. Metal coordination and covalent bonds improve the adhesion and self-healing properties, while the loading of Resina Draconis enhances the antibacterial properties of these hydrogels.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Infectious Diseases
Ali Pormohammad, Nadia K. Monych, Sougata Ghosh, Diana L. Turner, Raymond J. Turner
Summary: Wounds continue to be a serious medical concern, with infectious microbes in biofilm form delaying the healing process. Developing novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm, and wound healing properties are necessary. Nanomaterials show promising applicability for various wound types with their unique properties.
Article
Immunology
Ming-Wei Jan, Hong-Lin Su, Tsung-Hsien Chang, Kuen-Jer Tsai
Summary: Human parechovirus type 3 (PeV-A3) infection is identified as a cause of severe nerve disease or sepsis in infants and young children, with neuropathogenic mechanisms involving interferon and inflammatory cytokine expression, activation of death signaling pathways, and establishment of an experimental disease model of parechovirus encephalitis. In vivo studies in neonatal mice showed weight loss, paralysis, and mortality, with evidence of PeV-A3 infection, inflammatory cytokine expression, and death signaling transduction in the brain tissues. These findings suggest that PeV-A3-mediated neurological disorders involve activation of death signaling and inflammation responses, which may contribute to clinical manifestations associated with PeV-A3 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
AbdulRahman A. Saied, Manish Dhawan, Asmaa A. Metwally, Mathumalar Loganathan Fahrni, Priyanka Choudhary, Om Prakash Choudhary
Summary: Monkeypox is a zoonotic disease that spreads between animals and humans. The current outbreak is not related to travel and mainly spreads through close contact and exposure to contaminated materials. Diagnosis of monkeypox relies on nucleic-acid amplification testing, while other methods are time-consuming. There is no specific treatment for monkeypox, but vaccinia vaccine and certain drugs used for smallpox may be beneficial.
Article
Engineering, Biomedical
Changfa Sun, Wenjie Liu, Lili Wang, Run Meng, Jia Deng, Rui Qing, Bochu Wang, Shilei Hao
Summary: Infectious wounds pose significant challenges in clinical practice and developing new antibiotics has become increasingly difficult. In this study, a K31-PGLa hydrogel was designed and synthesized, which demonstrated synergistic effects with commercial antibiotics against drug-resistant bacteria by down-regulating efflux pump synthesis genes. Furthermore, the photopolymerized K31-PGLa/PEGDA hydrogels effectively inhibited the growth of drug-resistant bacteria and promoted skin wound closure in mice.
MATERIALS TODAY BIO
(2023)
Article
Medicine, General & Internal
Susanne Stampf, Nicolas J. Mueller, Christian van Delden, Manuel Pascual, Oriol Manuel, Vanessa Banz, Isabelle Binet, Sabina De Geest, Pierre-Yves Bochud, Alexander Leichtle, Stefan Schaub, Jurg Steiger, Michael Koller
Summary: The STCS is a large transplant cohort study that has enrolled over 5500 solid organ transplant recipients by the end of 2019. The study has published approximately 70 scientific papers and plans to further explore personalized medicine and digital epidemiology in the future.
Article
Medicine, General & Internal
Ralphe Bou Chebl, Rawan Safa, Mohammad Sabra, Ali Chami, Iskandar Berbari, Sarah Jamali, Maha Makki, Hani Tamim, Gilbert Abou Dagher
Summary: This study found that there was no significant difference in hospital mortality rates between solid tumor patients and hematological tumor patients presenting with sepsis or septic shock. However, hematological malignancy patients admitted with sepsis or septic shock had higher rates of bacteremia.
Article
Polymer Science
Mahalakshmi Pandian, G. Reshma, C. Arthi, Mar Masson, Jayakumar Rangasamy
Summary: Wound healing is a complex process, and the presence of bacteria can hinder this process, resulting in infectious wounds. Numerous biomedical and biomaterial research efforts have been made over the past 20 years to address this issue. Polymeric scaffolds and hydrogels are the best candidates for developing effective drug-delivery biomaterials.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Oncology
Liese Vandeborne, Pan Pantziarka, An M. T. Van Nuffel, Gauthier Bouche
Summary: This review summarizes research activities using approved vaccines to treat cancer, with data supporting cancer therapeutic use for 16 vaccines. Clinical trials have been conducted or are ongoing for 10 vaccines, while preclinical evidence supports further evaluation of the remaining 6 vaccines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Emelie Ohnstedt, Hava Lofton Tomenius, Peter Frank, Stefan Roos, Evelina Vagesjo, Mia Phillipson
Summary: Non-healing wounds are a growing medical problem that causes significant suffering. In this study, the topical administration of the drug candidate ILP100 proved to be safe and accelerated wound healing in minipigs, using different evaluation methods.
Article
Chemistry, Multidisciplinary
Nazila Farhangi Ghaleh Joughi, Mohammad Reza Farahpour, Mojtaba Mohammadi, Saeed Jafarirad, Sanaz Mahmazi
Summary: In this study, Ag/laterite nanocomposite (NC) coated with chitosan was synthesized for the treatment of infectious wounds. The synthesized NC showed antibacterial properties and promoted wound healing.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Medicine, General & Internal
Kayla Enriquez, Saned Raouf, John Shakpeh, Michelle Niescierenko, Finda Mayah-Toto
Summary: This study investigated the compliance with surgical antibiotic prophylaxis (SAP) and identified potential issues. The findings revealed low compliance and highlighted the need for further research and implementation of measures to ensure proper use of SAP.
Editorial Material
Dentistry, Oral Surgery & Medicine
Stefano Fedele, Stephen Porter
Letter
Dentistry, Oral Surgery & Medicine
Daniel Cohen Goldemberg, Andreia Cristina de Melo, Livia Cristina de Melo Pino, Heliton Spindola Antunes, Jair Carneiro Leao, Stephen Porter
Biographical-Item
Dentistry, Oral Surgery & Medicine
Stephen R. Porter, Alexander Crighton
Article
Oncology
Alessio Gambino, Adriana Cafaro, Roberto Broccoletti, Luca Turotti, Dora Karimi, Giorgia El Haddad, Colin Hopper, Stephen R. Porter, Luigi Chiusa, Paolo G. Arduino
Summary: Ulcers in the oral mucosa can be caused by various factors and are difficult to diagnose. Optical coherence tomography has been suggested as a potential method for diagnosing and distinguishing between traumatic and malignant ulcers.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dina Taimeh, Richeal Ni Riordain, Stefano Fedele, Rachel Leeson
Summary: This study aimed to explore the experiences of patients with TMDs in the National Health Service and their healthcare priorities when seeking treatment. Semi-structured interviews were conducted, and thematic analysis was used to identify key themes. The findings highlighted challenges and needs related to accessing appropriate care, receiving a diagnosis and sufficient information, interacting with clinical staff, treatment strategies and support.
Article
Dentistry, Oral Surgery & Medicine
Stefano Fedele, Arwa Al-Hamad, Valeria Mercadante, Stephen Porter, David Isenberg, Ana Poveda-Gallego, Sarah. T. T. Brown
Summary: This study explored the feasibility of salivary electrostimulation in individuals with primary Sjogren's syndrome and provided parameters for future phase III trials. The results showed that salivary electrostimulation could improve dry mouth symptoms in patients with Sjogren's syndrome without adverse events. The completion of this study provides reliable evidence for future trials.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Dina Taimeh, Richeal Ni Riordain, Stefano Fedele, Rachel Leeson
Summary: The aim of this study is to develop a patient-reported experience measure to evaluate the clinical experience of patients with temporomandibular disorders. Input from various sources, including literature, patients, and experts, was utilized to develop a preliminary questionnaire, which underwent cognitive testing to generate the final measure. This measure effectively evaluates the clinical experience of patients and has gained recognition with patient involvement.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
S. R. Porter, A. Ukwas
Summary: Cachexia is a common feature in patients with advanced malignancy of the head and neck, driven by various mechanisms induced by the tumor itself, leading to reduced nutritional intake, increased metabolism, and loss of adipose and skeletal tissue.
Article
Dentistry, Oral Surgery & Medicine
Waleed Alamoudi, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
Summary: This study aims to evaluate the content and quality of audiovisual online information about OED. The findings show that most of the materials are scientific in nature, with poor quality and lacking essential patient information. However, these materials could still be useful for patient education with improvements needed.
Article
Dentistry, Oral Surgery & Medicine
Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
Summary: This study aimed to assess the information needs of patients with chronic oral diseases and the agreement between clinicians and patients on important topics. The results showed that there were unmet needs regarding dysplasia, and clinicians were not able to fully predict patients' priorities.
Article
Dentistry, Oral Surgery & Medicine
Dina Taimeh, Richeal Ni Riordain, Stefano Fedele, Rachel Leeson
Summary: This study explored the structural validity and internal consistency reliability of General Anxiety Disorder-7, Patient Health Questionnaire-8, 15, and Jaw Functional Limitation Scale-20 in patients with chronic pain of temporomandibular disorders. The results showed positive evidence of structural validity and internal consistency of these questionnaires, suggesting their suitability for use in evaluating chronic pain in temporomandibular disorder patients.
Review
Dentistry, Oral Surgery & Medicine
Brittany A. Klein, Muhammad Ali Shazib, Alessandro Villa, Fabio de Abreu Alves, Piamkamon Vacharotayangul, Stephen Sonis, Stefano Fedele, Nathaniel S. Treister
Summary: ICIs can cause immune related adverse events, including orofacial manifestations. This review summarizes the characteristics of orofacial irAEs and provides guidance on identifying and managing these toxicities.
FRONTIERS IN ORAL HEALTH
(2022)
