Article
Medicine, Research & Experimental
Natalia Ivanjko, Nikola Stokovic, Marina Milesevic, Viktorija Rumenovic, Reinhard Windhager, Kuber T. Sampath, Natasa Kovacic, Danka Grcevic, Slobodan Vukicevic
Summary: Bone morphogenetic proteins (BMPs) require a suitable delivery system for treating spinal and bone defects. INFUSE, the only commercially available BMP-based device, has major disadvantages. A novel device called OSTEOGROW, containing BMP6 dispersed within autologous blood coagulum, shows promising results for bone regeneration. This study compares the release dynamics and cellular response of OSTEOGROW and INFUSE implants and demonstrates that OSTEOGROW is superior in inducing bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Orthopedics
Nikola Stokovic, Natalia Ivanjko, Marina Milesevic, Ivona Matic Jelic, Kristian Bakic, Viktorija Rumenovic, Hermann Oppermann, Larry Shimp, T. Kuber Sampath, Marko Pecina, Slobodan Vukicevic
Summary: The study demonstrated that the ABGS containing rhBMP6 and cylindrical ceramic blocks induced new bone formation in rats with improved biomechanical properties. The combination of components showed promising results, supporting potential clinical applications for bone regeneration.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Endocrinology & Metabolism
Christoph A. Lahr, Marietta Landgraf, Ferdinand Wagner, Amaia Cipitria, Ines Moreno-Jimenez, Onur Bas, Beat Schmutz, Christoph Meinert, Amanda Dos Santos Cavalcanti, Tomoji Mashimo, Yoshiki Miyasaka, Boris M. Holzapfel, Abbas Shafiee, Jacqui A. McGovern, Dietmar W. Hutmacher
Summary: An orthotopic humanised tissue-engineered osteosarcoma model in a genetically engineered rat has been successfully developed, allowing for the study of metastatic spread to the lung. The results highlight the crucial role of humanised animal models in bone disease research.
Article
Oncology
Lisa M. Butler, Emma Evergren
Summary: Membrane trafficking and organelle contact sites play important roles in regulating cell metabolism and survival, which are often deregulated in cancer. Prostate cancer is a leading cause of cancer-related death in men, and there is a need to identify prognostic biomarkers and therapeutic targets. This study explored the morphology of organelles and membrane contact sites in prostate cancer tissue and found that there are adaptations in membrane contact sites between mitochondria and the ER during prostate cancer progression. These adaptations are androgen-dependent and may support pro-proliferative signaling and metabolic changes in prostate cancer cells.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Philippa A. Hulley, Helen J. Knowles
Summary: This study presents a novel approach to differentiate primary human CD14+ monocyte-derived osteoclasts in 3D collagen gels. The method allows for the enrichment and study of differentiating subpopulations of osteoclasts, providing a new avenue for investigating molecular mechanisms of human osteoclasts.
Article
Multidisciplinary Sciences
Camila Soares Lopes, Mateus Machado Delfino, Mario Tanomaru-Filho, Estela Sasso-Cerri, Juliane Maria Guerreiro-Tanomaru, Paulo Sergio Cerri
Summary: This study evaluated the biocompatibility and hepatotoxicity of a new bioceramic intracanal medicament, Bio-C Temp. The results showed that Bio-C Temp is biocompatible and does not have hepatotoxic effects.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Manuel Estevez, Giorgia Montalbano, Alvaro Gallo-Cordova, Jesus G. Ovejero, Isabel Izquierdo-Barba, Blanca Gonzalez, Clarissa Tomasina, Lorenzo Moroni, Maria Vallet-Regi, Chiara Vitale-Brovarone, Sonia Fiorilli
Summary: Nowadays, there is growing interest in developing systems that can guide and influence cell activities for bone regeneration. In this study, researchers combined type-I collagen and superparamagnetic iron oxide nanoparticles (SPIONs) to design magnetic and biocompatible electrospun scaffolds for bone regeneration. The experimental results showed that the nanostructured scaffolds composed of collagen fibers with embedded SPIONs exhibited enhanced magnetic properties and preserved the viability and adhesion of bone cells.
Article
Geography, Physical
Luciano Varela, Lucia Clavijo, P. Sebastian Tambusso, Richard A. Farina
Summary: Stable isotope analysis is a valuable tool for understanding the paleoecology and paleodiet of fossil mammals. By studying the stable isotope composition of fossil bones from a site in southern Uruguay, researchers found that the herbivorous species in the area consumed a high proportion of C-3 plants, indicating a dry environment. The results also suggest niche partitioning among different species.
QUATERNARY SCIENCE REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
William A. Lackington, Dominic Gehweiler, Ivan Zderic, Dirk Nehrbass, Stephan Zeiter, Arlyng Gonzalez-Vazquez, Fergal J. O'Brien, Martin J. Stoddart, Keith Thompson
Summary: This study aimed to determine the therapeutic efficacy of rhBMP-2 using different scaffolds. The collagen-hydroxyapatite scaffold showed enhanced therapeutic efficacy compared to collagen-only scaffolds. Limited luminal remodeling was observed in both CO and CHA groups.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Phebe H. van Langevelde, Errikos Kounalis, Lars Killian, Emily C. Monkcom, Daniel L. J. Broere, Dennis G. H. Hetterscheid
Summary: This study reports a dinuclear copper complex inspired by the active site of multicopper oxidases (MCOs), which undergoes a proton-coupled electron transfer pathway during its electrochemical reduction process, resulting in a larger overpotential. The study also reveals the role of metal-metal cooperativity and the constraints of a rigid ligand framework in catalysis, leading to an improved selectivity for the oxygen reduction reaction (ORR) due to better stabilization of reaction intermediates between the copper centers.
Article
Chemistry, Multidisciplinary
Hsiu-Mei Lin, Chih-Hwa Chen, Fu-Yin Hsu, Zhi-Yuan Wu, Pei-Chun Wong
Summary: In this study, mesoporous bioactive glass (MBG) was synthesized from diatom, a natural material.The surface morphology of MBG was observed using transmission electron microscope, and its physical properties were analyzed by X-ray diffraction and thermogravimetric analysis. The biocompatibility was determined by MTT assay. MBG was then combined with gelatin to form a nanofiber matrix through electrospinning. Activated growth factors were grafted on the surface of the nanofiber matrix using ethyl(dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide. The nanofiber structure of MBG was observed using scanning electron microscope. The in vivo biocompatibility and bone healing were analyzed through animal experiments and histology. The results demonstrated that MBG had no organic residue and a pore size of approximately 10 nm. The MBG nanofiber matrix significantly improved bone healing compared to the control group. Overall, the MBG nanofiber matrix has great potential in orthopedic applications for enhancing bone-tendon healing.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Food Science & Technology
Zitao Guo, Bo Hu, Lingyu Zhu, Yuliang Yang, Chunyu Liu, Fan Liu, Yi Shi, Moying Li, Zhenghua Gu, Yu Xin, Dalong Yi, Huaigao Liu, Liang Zhang
Summary: This study conducted a twelve-week intervention to investigate the anti-obesity effects of yak bone collagen hydrolysates (YBCH) on mice with a high-fat diet. The results indicated that supplementation with YBCH ameliorated the obesity-associated phenotypes of mice, which might be achieved by regulating the gut microbiota.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Carmen Esposito, Melania Gigante, Federico Lugli, Pasquale Miranda, Claudio Cavazzuti, Alessandra Sperduti, Marco Pacciarelli, Simon Stoddart, Paula Reimer, Caroline Malone, Luca Bondioli, Wolfgang Mueller
Summary: The Early Iron Age in Italy saw significant changes that influenced the political and cultural landscape of the peninsula. Settlements by people from the eastern Mediterranean had an impact on Italy, Sardinia, and Sicily. The Villanovan culture, particularly in central and southern Italy, played a leading role in interaction with diverse groups. This study examines human mobility in Fermo during the Early Iron Age using archaeological, osteological, and isotope data, shedding light on connectivity dynamics in Italian frontier sites.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Zhifa Wang, Leng Han, Ye Zhou, Jiacheng Cai, Shuohui Sun, Junli Ma, Weijian Wang, Xiao Li, Limin Ma
Summary: Cell sheet technology combined with 3D-printed titanium alloy scaffolds can be used to fabricate biomimetic engineered bone, offering a novel and promising strategy for the precise repair of bone defects. The combination of bone marrow mesenchymal stem cell sheet technology and 3D porous titanium alloy scaffolds enhances the biological behaviors of cells and increases the angiogenic potential of the scaffolds.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Karel Klima, Dan Ulmann, Martin Bartos, Michal Spanko, Jaroslava Duskova, Radka Vrbova, Jan Pinc, Jiri Kubasek, Marek Vlk, Tereza Ulmannova, Rene Foltan, Eitan Brizman, Milan Drahos, Michal Beno, Vladimir Machon, Jaroslav Capek
Summary: In an experimental study, an extruded Zn-0.8Mg-0.2Sr alloy was analyzed for biocompatibility and toxicity on a rabbit model, demonstrating good biocompatibility without signs of toxicity at the implantation site. The alloy slowly degraded in vivo, forming solid corrosion products on its surface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
