Review
Biochemistry & Molecular Biology
Steven He, Rajdeep Chakraborty, Shoba Ranganathan
Summary: Oral cancer is a common type of head and neck squamous cell carcinoma, with a high mortality rate. International research on the molecular pathways of oral cancer has implications for early diagnosis, prognosis, and the development of new drugs. This review focuses on the pathways of proliferation and apoptosis in OSCC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jian Wang, Zhi-ya Zhang, Jie Jiang, Li Tang, Xiao-yan Wang, Zhen Wang, Xue-lian Yang, Xin-lin Yu, Cheng-chen Huang, Feng Chen, Hai-su Wan, Su-juan Ye
Summary: The histone demethylase KDM2A plays an oncogenic role in esophageal squamous cell carcinoma, with its depletion inhibiting malignant phenotypes and overexpression having the opposite effect. KDM2A induces a set of oncogenic gene expressions while suppressing others, demonstrating its dual role in ESCC cells. Targeted inhibition of upregulated oncogenes in KDM2A-depleted cells shows a synergistic suppressive effect on ESCC malignant phenotypes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jun Liang, Jingang Liu, Zhaoming Deng, Zhigang Liu, Lizhong Liang
Summary: DLX6 is overexpressed in oral cancer tissues and is associated with advanced tumor stage and poor prognosis. DLX6 promotes proliferation and inhibits cell apoptosis in oral cancer cells. The EGFR-CCND1 pathway may be a potential mechanism involved in the regulatory axis.
Article
Oncology
Yuanyuan Kang, Ying Zhang, Yan Sun
Summary: miR-198 downregulation in OSCC tissues and cell lines is associated with poor overall survival and disease-free survival. Overexpression of miR-198 significantly inhibits proliferation, invasion, and EMT of OSCC cells. Luciferase assay results demonstrate that miR-198 interacts with CDK4 by directly targeting its binding site in the CDK4 sequence.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunguang Zhao, Zhiyun Liu
Summary: It has been discovered that SERPINE1 is highly expressed in oral squamous cell carcinoma (OSCC) and exerts oncogenic effects through a mechanism mediated by miR-617. The miR-617/SERPINE1 axis may serve as a potential therapeutic target for OSCC.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yue Xiao, Yanjun Duan, Yongjie Wang, Xiaojia Yin
Summary: The study demonstrated that resveratrol inhibits the growth and promotes apoptosis of CAL-27 oral squamous cell carcinoma cells by regulating the ZNF750/RAC1 signaling pathway. Resveratrol also suppresses malignant progression by modulating the expression of angiogenin, cell adhesion molecules, and vascular markers.
Article
Biochemistry & Molecular Biology
Shanshan Liu, Wenzhen Gao, Yupu Lu, Qin Zhou, Rongjian Su, Tomoka Hasegawa, Juan Du, Minqi Li
Summary: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck with a poor prognosis and unsatisfactory treatment. This study found that the protein histidine phosphatase LHPP plays an important role in the development of OSCC. LHPP inhibits the growth and migration of OSCC by decreasing the activity of the PI3K/AKT signaling pathway and promoting apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xiaotao Zheng, Fang Du, Xuepeng Gong, Ping Xu
Summary: Circ_0005320 is upregulated in oral squamous cell carcinoma (OSCC) and promotes tumor progression. Knockdown of circ_0005320 inhibits cell growth, migration, and invasion, and induces apoptosis in OSCC. The circ_0005320-miR-486-3p/miR-637 axis mediates the activation of the JAK2/STAT3 pathway.
Article
Gastroenterology & Hepatology
Bin Sun, Weidan Ji, Chunying Liu, Xuejing Lin, Lei Chen, Haihua Qian, Changqing Su
Summary: miR-2392 is significantly down-regulated in HCC and functions as a tumor suppressor by targeting JAG2 to inhibit proliferation, clonogenicity, mobility, spheroid formation, and maintenance of CSC-like characteristics in HCC cells. CTCs from HCC patients with lower serum miR-2392 levels exhibit stronger spheroid formation ability, and a negative correlation between miR-2392 levels in serum and the number of CTC spheroids has been observed. JAG2 is highly expressed in HCC and is associated with poor prognosis and patient survival.
LIVER INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ke Huang, Zhibin Liu, Myoung-Ok Kim, Ki-Rim Kim
Summary: The study found that gossypetin can inhibit the proliferation, migration, and invasion of oral squamous cell carcinoma cells, and exert its anticancer effects by inducing apoptosis and cell cycle arrest. These findings suggest that gossypetin has the potential to be used as a chemopreventive agent for oral cancer.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Oncology
L. Liu, B. Guo, Y. Han, S. Xu, S. Liu
Summary: This study uncovered a functional role of MARCH1 in oral squamous cell carcinoma (OSCC) and identified PHLPP2 as an important target of MARCH1 for modulating OSCC cell proliferation and apoptosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hong Zhang, Zhenhua Wang, Zhongti Zhang
Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.
Article
Biochemistry & Molecular Biology
Lin Qiu, Han Liu, Shuang Wang, Xiao-Hua Dai, Jian-Wei Shang, Xiao-Li Lian, Guan-Hua Wang, Jun Zhang
Summary: Oral squamous cell carcinoma (OSCC) is a major cause of cancer-related death worldwide, with its pathophysiology involving abnormal expression of the FKBP11 gene. Research has shown that FKBP11 promotes the progression of OSCC by regulating cell proliferation, cell cycle, and apoptosis pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Yujia Wang, Ruixin Wang, Bowen Li, Zhuoshan Huang, Sufeng Zhao, Suling Chen, Tianjun Lan, Siqi Ren, Fan Wu, Jing Tan, Jinsong Li
Summary: Cancer-associated fibroblasts (CAFs) play a significant role in tumor development and progression. This study found that CAFs derived from the invasive tumor front (CAFs-F) have a greater ability to promote tumor invasion compared to CAFs derived from the superficial tumor (CAFs-S). The increased expression of MFAP5 in CAFs-F may be involved in this process.
Article
Oncology
Yajun Shen, Haoyue Xu, Lingyu Li, Yunping Lu, Min Zhang, Xin Huang, Xiaofei Tang
Summary: This study found that PRDX1 is the only highly expressed member of the PRDX family in OSCC that affects patient prognosis, and its expression is closely related to tumor characteristics. GSEA results showed that the high expression of PRDX1 is involved in multiple cancer-related functions and signaling pathways.
CANCER MANAGEMENT AND RESEARCH
(2021)
