Article
Engineering, Biomedical
Naiwei Chi, Svjetlana Lozo, Rathnayake A. C. Rathnayake, Sylvia Botros-Brey, Yin Ma, Margot Damaser, Rong R. Wang
Summary: In this study, the multiscale structure, molecular composition, and biomechanics of collagen fibrils in connective tissues of healthy women and POP patients were analyzed. The correlation between these properties and clinical POP quantification scores was established. The study revealed that collagen characteristics change with the progression of POP, suggesting a link between severe prolapse and altered collagen properties. The findings also indicate that the deterioration of the collagen matrix is synchronized with prolapse progression. These results highlight the potential of using non-invasive clinical tests to quantitatively assess collagen abnormalities and guide personalized treatment for POP patients.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Rory Gibney, Eleonora Ferraris
Summary: The study utilized aerosol jet printing to process collagen type I and II into dense constructs with suitable mechanical properties for replicating dense collagenous connective tissues. Collagen type II exhibited lower viscosity compared to type I, and both types experienced a drop in viscosity due to aerosol jet printing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Costantino Casale, Giorgia Imparato, Claudia Mazio, Paolo A. Netti, Francesco Urciuolo
Summary: Alignment of ECM in engineered tissues can affect cell behavior and tissue properties, with high aspect ratio chambers promoting spontaneous alignment of collagenous network. This alignment provides contact guidance for the formation of highly polarized capillary-like structures, suggesting potential application for fast angio-genesis in damaged aligned tissues.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Naim Kittana, Mohyeddin Assali, Wolfram-Hubertus Zimmermann, Norman Liaw, Gabriela Leao Santos, Abdul Rehman, Susanne Lutz
Summary: The study showed that reinforcement of ECT using C-MWCNT can enhance the biophysical properties of the tissue, including increased stiffness, reduced contraction, improved elasticity and extensibility, as well as higher resilience and toughness compared to control tissues.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Linda Irons, Cristina Cavinato, Jay D. Humphrey
Summary: The healthy adult aorta can adapt to sustained changes in hemodynamic loads, but this ability can be compromised in aging and pathological processes. This study investigates persistent non-homeostatic changes in the thoracic aorta of mice with hypertension. A computational model is used to analyze the effects of mechanosensitive and angiotensin II-related cell signaling pathways. The findings suggest that altered properties of collagen deposited during hypertension may persist even after blood pressure is restored to normal levels.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Jonas F. Eichinger, Daniel Paukner, Roland C. Aydin, Wolfgang A. Wall, Jay D. Humphrey, Christian J. Cyron
Summary: Cells in soft biological tissues regulate the mechanical state of the extracellular matrix to ensure structural integrity and functionality, known as mechanical homeostasis. This process plays a crucial role in diseases like aneurysms and cancer. By combining experiments, computer simulations, and theoretical analysis, a likely candidate for the target quantity that cells regulate has been identified on short time scales and in simplified tissue models.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Kexin Jiao, Laurence J. Walsh, Saso Ivanovski, Pingping Han
Summary: Periodontitis is a chronic inflammatory disease that leads to irreversible loss of tooth-supporting tissues. Circular RNAs (circRNAs) found in oral tissue are expressed in a tissue-specific manner and play crucial regulatory functions in diseases, including periodontitis. CircRNAs are associated with pathological periodontitis tissues and play a role in periodontal cell differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tomomi Nakamura, Motozo Yamashita, Kuniko Ikegami, Mio Suzuki, Manabu Yanagita, Jirouta Kitagaki, Masahiro Kitamura, Shinya Murakami
Summary: The study revealed that autophagy plays a crucial role in regulating type I collagen synthesis in HPDL cells by eliminating misfolded proteins. Inhibition of autophagy suppressed collagen production and partly regulated osteoblastic differentiation of PDL cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Alexey A. Ivanov, Tamara I. Danilova, Alla V. Kuznetsova, Olga P. Popova, Oleg O. Yanushevich
Summary: The regeneration of periodontal tissues is important for the treatment of periodontitis. This study investigated the osteogenic and odontogenic differentiation of periodontal progenitor and stem cells in decellularized tooth matrix (dTM) and periodontal ligament (dPDL) in both 2D and 3D culture conditions. The results showed that the combination of dTM and dPDL promoted both osteogenic and odontogenic differentiation of periodontal cells.
Review
Immunology
Anna Estrada Brull, Camilla Panetti, Nicole Joller
Summary: Regulatory T cells (Tregs) not only suppress immune responses, but also promote tissue homeostasis, regeneration, and repair in non-lymphoid tissues. This review discusses the migration of Tregs to peripheral tissues, their functions in different tissues, and their interactions with non-immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andressa V. B. Nogueira, Marjan Nokhbehsaim, Anna Damanaki, Sigrun Eick, Svenja Beisel-Memmert, Christian Kirschneck, Agnes Schroeder, Thamiris Cirelli, Natalia D. P. Leguizamon, Joni A. Cirelli, James Deschner
Summary: The impact of bacterial infection on the expression of growth hormone secretagogue receptor (GHS-R) was studied in periodontal cells and tissues, along with the evaluation of ghrelin. The results showed that bacterial infection upregulated GHS-R expression and protein level in periodontal tissues and human gingival fibroblasts (HGFs). Ghrelin was found to inhibit the proinflammatory effects of the bacteria on HGFs without affecting cell viability and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Birgit Rath-Deschner, Andressa Vilas Boas Nogueira, Svenja Memmert, Marjan Nokhbehsaim, Joni Augusto Cirelli, Sigrun Eick, Nicolai Miosge, Christian Kirschneck, Marco Kesting, James Deschner, Andreas Jaeger, Anna Damanaki
Summary: The study revealed that SOD2 and BIRC3 are produced as a protective mechanism against exaggerated apoptosis in periodontal infection. However, in the presence of orthodontic forces, this protective anti-apoptotic mechanism may be diminished.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jiusi Guo, Zhenyu Xing, Luchang Liu, Yimin Sun, Hongju Zhou, Mingru Bai, Xikui Liu, Mohsen Adeli, Chong Cheng, Xianglong Han
Summary: Efficient antioxidase-like nanobiocatalysts (ROBCs) based on Ru-porphyrin-networks (Ru-Por-Net) are reported, showing excellent catalytic ROS-scavenging activities. The Ru-Por-Net-based ROBCs are more efficient than state-of-the-art anti-ROS biocatalysts. This study provides insights into the crucial functions of Ru-N coordinated porphyrin-networks in catalytic ROS-scavenging and offers a new strategy for designing high-performance nanobiocatalysts.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Berta H. Ganizada, Koen D. Reesink, Shaiv Parikh, Mitch J. F. G. Ramaekers, Asim C. Akbulut, Pepijn J. M. H. Saraber, Gijs P. Debeij, Ehsan MUMC TAA Student Team, Armand M. Jaminon, Ehsan Natour, Roberto Lorusso, Joachim E. Wildberger, Barend Mees, Geert Willem Schurink, Michael J. Jacobs, Jack Cleutjens, Ingrid Krapels, Alexander Gombert, Jos G. Maessen, Ryan Accord, Tammo Delhaas, Simon Schalla, Leon J. Schurgers, Elham Bidar
Summary: Current management guidelines for ascending thoracic aortic aneurysms (aTAA) suggest intervention once the diameter reaches 5-5.5 cm or shows a growth rate of >0.5 cm/year. However, aTAA dissections (aTAAD) often occur in vessels with diameters below the surgical intervention threshold. To improve understanding of aTAA pathophysiology, the MAPEX platform focuses on the interactions between vascular smooth muscle cells and extracellular matrix, aiming to narrow knowledge gaps and improve diagnostic and prognostic possibilities.
Article
Neurosciences
Masanori Honsho, Yukio Fujiki
Summary: Plasmalogens are cellular glycerophospholipids with a vinyl-ether bond, synthesized in peroxisomes and endoplasmic reticulum. Deficiency in plasmalogens indicates the importance of de novo synthesis in plasmalogen homeostasis. The regulation of plasmalogen biosynthesis is controlled by a feedback mechanism that senses plasmalogen levels in the inner leaflet of the plasma membrane. Dysregulation of plasmalogen synthesis impairs cholesterol synthesis and affects gene expression, resulting in pathogenesis in rodents and humans.
BRAIN RESEARCH BULLETIN
(2023)
