Journal
OPTICS LETTERS
Volume 36, Issue 23, Pages 4545-4547Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.36.004545
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Funding
- National Defense Medical College
- Mistry of Education, Culture, Sports, Science and Technology of Japan
- Japanese Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [10J04881] Funding Source: KAKEN
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We developed an optical-fiber-based photomechanical gene transfer system for endoscopic or catheter-based application. A fiber tip with a laser-absorbing film covered with a transparent plastic disk for plasma confinement was attached to a quartz fiber; the film was irradiated with nanosecond laser pulses transmitted through the fiber to generate photomechanical waves (PMWs). Characteristics of PMWs emitted from the fiber tip were examined to confirm the necessary conditions for gene transfer. We then attempted to transfer reporter genes to the rat skin as a test tissue in vivo with the fiber system, and the results showed significantly high protein levels and spatially selective pinpoint gene expressions in the tissue. (C) 2011 Optical Society of America
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