Journal
OPTICS LETTERS
Volume 34, Issue 23, Pages 3746-3748Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.34.003746
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Funding
- Vernieuwingsimpuls program [MCGA: AGT07547, DJF: AGT07544]
- Netherlands Organization of Scientific Research (NWO)
- Technology Foundation
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Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/- 0.5 mm (1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations. (C) 2009 Optical Society of America
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