Journal
OPTICS LETTERS
Volume 33, Issue 9, Pages 914-916Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.33.000914
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Funding
- National Research Foundation of Korea [R11-2000-075-01001-0, 과06A1604] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We demonstrate that surface plasmon resonance (SPR) is applicable to the optical detection of neural signals. A low-noise SPR sensor was developed as a label- and artifact-free method for the extracellular recording of neural activity. The optical responses obtained from a rat sciatic nerve were highly correlated with simultaneously recorded electrical responses. Additional studies with stimulation intensity and lidocaine further confirmed that the optically measured signals originated from neural activities. (C) 2008 Optical Society of America.
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