Journal
OPTICS EXPRESS
Volume 21, Issue 22, Pages 27023-27031Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.21.027023
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Funding
- CAPES-STINT/Brazil-Sweden collaboration program
- Brazilian Agency CNPq
- CAPES-STINT
- FAPERJ
- CNPq
- Center of Excellence in Nanophotonics and Biophotonics (PRONEX/FACEPE/CNPq)
- INCT Fotonica (CNPq)
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Dengue fever is a viral disease that affects millions of people worldwide. Specific tests for dengue are not usually performed due to high costs, complicated procedures and, in some cases, long time to yield a result. For widespread use of specific tests to be possible, fast, reliable and fairly simple methods are needed. In this paper, we present a new dengue diagnostic method for the acute phase of the infection. The method proposed uses an all-optical fiber sensor based on Localized Surface Plasmon Resonance (LSPR) and specular reflection from gold nanoparticles (AuNPs). Dengue anti-NS1 antibody was immobilized on AuNPs deposited on the endface of a standard multimode fiber (62.5 mu m/125 mu m). The sensor is able to detect NS1 antigen at different concentrations, with limit of quantification estimated to be 0.074 mu g/ml = 1.54 nM. These results indicate that the sensor could potentially be used for dengue diagnosis in the acute phase of the infection. (C) 2013 Optical Society of America
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