Article
Optics
Zhenhe Ma, Ning Ding, Zhen Li, Keliang Zhu, Ang Li, Zhanhong Lin, Yi Wang, Yuqian Zhao, Yao Yu, Jingmin Luan, Xin Zhu, Jian Liu
Summary: This article introduces a method to extract the photoacoustic (PA) signal from the contrast reduction in the interference spectrum obtained from spectral domain optical coherence tomography (SDOCT). The method utilizes the specular reflection on the water surface to achieve all-optical detection in a non-contact manner. By analyzing the phase changes in the interference spectrum induced by water surface vibration, the method enables quantification of the interference contrast reduction for PA imaging.
Article
Optics
Yuye Ling, Zhenxing Dong, Xueshen Li, Yu Gan, Yikai Su
Summary: With the advancement of light source technology, the A-line imaging rate of SS-OCT has significantly increased in the past three decades. However, the bandwidths of data acquisition, transfer, and storage have become major limitations in modern SS-OCT system design. To address this, a novel design paradigm is proposed where the sub-sampling pattern for interferogram acquisition is jointly optimized with the reconstruction algorithm. This method achieves high data compression ratios without impairing image quality, making it a potential solution for the data issue in SS-OCT.
Article
Optics
Tanbin Shao, Kecheng Yang, Min Xia, Wenping Guo
Summary: In this study, an enhanced dispersion-encoded full-range spectral interferometry technique is proposed and validated for improving measurement accuracy in samples with significant depth, inclination, and roughness. By removing the direct current and preserving data with good phase continuity, the accuracy of phase compensation is improved. The proposed technique extends the depth measurement range and achieves high axial measurement precision.
Article
Biology
Shuo Chen, Da Ma, Sieun Lee, Timothy T. L. Yu, Gavin Xu, Donghuan Lu, Karteek Popuri, Myeong Jin Ju, Marinko Sarunic, Mirza Faisal Beg
Summary: This study introduces a segmentation-driven domain adaptation method for retinal imaging processing, which utilizes CycleGAN to improve domain adaptation. A two-stage pipeline is proposed to train a segmentation model in the source domain and adapt the images from the target domain. Experimental results demonstrate that the proposed method achieves improved segmentation performance and image quality.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Lisa Toto, Maria Ludovica Ruggeri, Federica Evangelista, Chiara Trivigno, Rossella D'Aloisio, Chiara De Nicola, Pasquale Viggiano, Emanuele Doronzo, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study investigates the parameters of optical coherence tomography (OCT) and OCT angiography (OCTA) in patients with neovascular age-related macular degeneration (nAMD) and macular neovascularization (MNV) types 1, 2, and 3. The results showed significant differences in CVI, CMT, and ORCCFA between MNV 1 and the other two groups. CVI was significantly different between MNV 1 and healthy controls and between MNV 1 and MNV 2. ORCCFA and CMT were significantly different between MNV 1 and MNV 2. There was no statistically significant difference in subfoveal choroidal thickness (SFCT) among the three groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Optics
Yukun Wang, Si Chen, Kan Lin, Xi Chen, Zhengyang Xu, Shiliang Lou, Xin Ge, Guangming Ni, Xiaojun Yu, Jianhua Mo, Quanquan Mu, Linbo Liu
Summary: Multi-channel detection is an effective way to improve data throughput of spectral-domain optical coherence tomography (SDOCT). However, the current approach using multiple detectors increases system complexity and cost. We propose a novel multi-channel detection design based on a single spectrometer, which broadens the spectral bandwidth of each pixel, reducing relative intensity noise (RIN). The theoretical and experimental analysis shows that this design effectively improves sensitivity, especially for systems dominated by electrical noise or RIN.
CHINESE OPTICS LETTERS
(2023)
Article
Engineering, Biomedical
Xueshen Li, Shengting Cao, Hongshan Liu, Xinwen Yao, Brigitta C. Brott, Silvio H. Litovsky, Xiaoyu Song, Yuye Ling, Yu Gan
Summary: This study proposes a method of speeding up imaging of coronary artery disease by downsizing the data acquisition process in both the spectral and spatial domains, and improving the quality of image reconstruction through a multiscale reconstruction framework. Experimental results show that data downscaled in both the spectral and spatial domains are easier to reconstruct compared to data downscaled solely in either domain.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chen Huang, Keren Xie, Yuhan Zhang, Mingchao Li, Songtao Yuan, Qiang Chen
Summary: The proposed fusion method combining SD-OCT and OCTA images is more effective for CNV visualization, providing a satisfying visual effect by integrating complementary information from multimodal images.
Article
Engineering, Electrical & Electronic
Prabhav Gaur, Andrew Grieco, Yeshaiahu Fainman
Summary: This article presents a method to improve the performance of spectral domain optical coherence tomography by using phase modulators and delay lines as filters, scanning multiple channels and combining them in a digital computer.
IEEE PHOTONICS JOURNAL
(2023)
Article
Chemistry, Analytical
Hong-Yan Zheng, Bo-Liang Chen, Hsiao-Yen Lu, Shih-Hsiang Hsu, Masanori Takabayashi
Summary: A chip-based SD-OCT system utilizes a MZDC structure and an echelle grating for improving signal-to-noise ratios, wavelength response, axial resolution, and sensitivity.
Article
Biotechnology & Applied Microbiology
Di Yang, Weike Wang, Zhuoqun Yuan, Yanmei Liang
Summary: In this study, a high-resolution multi-functional optical coherence tomography (OCT) was used to obtain detailed intra- and extracranial imaging outcomes of adult zebrafish, including pigmentation distribution, tissue-specific information, cranial vascular imaging, and the monitoring of traumatic brain injury (TBI). Additionally, the channels through the zebrafish cranial suture were observed for the first time, which may have a crucial function in maintaining the patency of the cranial sutures. The results demonstrate that the high-resolution multi-functional OCT system can provide a wealth of novel and interpretable biological information for intra- and extracranial studies of adult zebrafish.
BIOENGINEERING-BASEL
(2023)
Article
Ophthalmology
Haidong Li, Lifeng Chen, Meng'ai Wu, Bin Zheng
Summary: This study investigated the characteristics of cystic retinal tufts (CRTs) using widefield spectral-domain optical coherence tomography. The results showed that CRTs exhibited hyperreflective irregular elevated lesions with internal hyporeflective cystoid cavities on SD-OCT images. Widefield SD-OCT imaging provides detailed anatomical information and may guide clinical treatment.
Article
Biochemical Research Methods
Muktesh Mohan, Raju Poddar
Summary: The study synthesized a multimodal imaging probe with both upconversion and paramagnetic properties for optical coherence tomography systems, demonstrating its potential for targeted imaging applications.
JOURNAL OF FLUORESCENCE
(2021)
Article
Biophysics
Yixuan Ming, Senyue Hao, Fei Wang, Yonatan R. Lewis-Israeli, Brett D. Volmert, Zhiyao Xu, Anna Goestenkors, Aitor Aguirre, Chao Zhou
Summary: Organoids are important in vitro models for studying organ development, disease mechanisms, and drug discovery. Recently, three groups independently developed self-assembling human heart organoids from human pluripotent stem cells. In this study, a customized spectral-domain optical coherence tomography system was used to characterize the growth of the heart organoids. The results showed the potential of the organoids as an in vitro platform for investigating heart development and disease mechanisms.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Babak Ghafaryasl, Koenraad A. Vermeer, Jeroen Kalkman, Tom Callewaert, Johannes F. de Boer, Lucas J. van Vliet
Summary: Optical coherence tomography (OCT) is widely used for capturing structural information of tissues for clinical tasks such as diagnosing retinal and vascular diseases. Recently, there has been a growing interest in the field of ophthalmology for utilizing optical tissue properties for diagnosis and disease progression.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemical Research Methods
M. Shahidul Islam, Michael C. Oliveira, Yan Wang, Francis P. Henry, Mark A. Randolph, B. Hyle Park, Johannes F. de Boer
JOURNAL OF BIOMEDICAL OPTICS
(2012)
Article
Biochemical Research Methods
Melissa M. Eberle, Carissa L. Reynolds, Jenny I. Szu, Yan Wang, Anne M. Hansen, Mike S. Hsu, M. Shahidul Islam, Devin K. Binder, B. Hyle Park
BIOMEDICAL OPTICS EXPRESS
(2012)
Article
Multidisciplinary Sciences
Jenny I. Szu, Melissa M. Eberle, Carissa L. Reynolds, Mike S. Hsu, Yan Wang, Christian M. Oh, M. Shahidul Islam, B. Hyle Park, Devin K. Binder
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2012)
Article
Neurosciences
Carissa L. R. Rodriguez, Jenny I. Szu, Melissa M. Eberle, Yan Wang, Mike S. Hsu, Devin K. Binder, B. Hyle Park
Proceedings Paper
Engineering, Biomedical
M. Shahidul Islam, Md Rezuanul Haque, Christian M. Oh, Yan Wang, B. Hyle Park
PHOTONIC THERAPEUTICS AND DIAGNOSTICS IX
(2013)
