Article
Chemistry, Analytical
Jun-Hao Wan, Chen Qian, Gang Wu, Xian-Wei Liu
Summary: Label-free imaging of nanoscale targets with intrinsic properties is crucial for unveiling the underlying mechanisms of chemistry, physics, and life science. Plasmonic imaging techniques provide real-time imaging and insights into nanoscale detection and nanocatalysis. In this study, a high-resolution plasmonic imaging method is presented, demonstrating its capability to image various nanomaterials and accurately track the interfacial dynamics of nanoparticles. With the simplicity and capacity for label-free and real-time imaging, this approach serves as a promising platform for characterizing nanomaterials at the single-particle level.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Lili Zhang, Jiachen Ma, Baozhi Cheng, Fang Lin
Summary: In this paper, a tensor RX algorithm based on fractional Fourier transform (FrFT-TRX) is proposed for hyperspectral anomaly detection. By selecting the fractional order of FrFT and exploiting the complementary advantages of the intermediate domain, the proposed algorithm achieves superior performance in the experiment.
Article
Multidisciplinary Sciences
Cory Juntunen, Isabel M. Woller, Andrew R. Abramczyk, Yongjin Sung
Summary: In this study, deep learning is applied to Fourier transform imaging spectroscopy (FTIS) to significantly reduce interferogram sampling and improve imaging throughput without degrading image quality. The deep learning approach also demonstrates better robustness to translation stage error and environmental vibrations, eliminating the need for He-Ne correction in FTIS systems and reducing cost and complexity.
SCIENTIFIC REPORTS
(2022)
Article
Geochemistry & Geophysics
Bing Tu, Zhi Wang, Huiting Ouyang, Xianchang Yang, Jun Li, Antonio Plaza
Summary: Anomaly detection is a crucial technique in hyperspectral image processing, aiming to identify pixels significantly different from the background when target spectrum is unavailable. This article introduces a novel anomaly detection method called Spectral-Spatial Graph (SSG) that combines spatial and spectral information, resulting in improved detection performance compared to other algorithms.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Review
Chemistry, Multidisciplinary
Jia-Sheng Lin, Xiang-Dong Tian, Gang Li, Fan-Li Zhang, Yan Wang, Jian-Feng Li
Summary: The use of imaging technologies is crucial in understanding biological phenomena. Traditional imaging modalities lack the necessary spatial resolution for high-precision research and diagnosis in the biomedical field. Plasmon resonance, an interaction between light and matter, allows for intense electromagnetic fields and enhances various processes such as ablation, scattering, and photoluminescence. By combining spatially resolved capability with molecular spectrometry techniques, excellent imaging techniques have been developed for studying biological processes. This review provides an overview of plasmonics and discusses the working principles and achievable spatial resolutions of various plasmon-based imaging techniques.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Instruments & Instrumentation
Lili Zhang, Baozhi Cheng, Fang Lin
Summary: This article proposes a novel anomaly detection algorithm based on fractional Fourier transform and deep belief networks. The algorithm combines the spatial and spectral characteristics of test HSI, and utilizes dimensionality reduction and reconstruction error calculation in the fractional Fourier domain to achieve effective anomaly detection.
INFRARED PHYSICS & TECHNOLOGY
(2022)
Article
Remote Sensing
Xiaobin Zhao, Zengfu Hou, Xin Wu, Wei Li, Pengge Ma, Ran Tao
Summary: This algorithm improves the separability of background and target by projecting the original spectral information into the fractional domain using fractional Fourier transform. By utilizing a revised constrained energy minimization detector and sliding double window strategy, it effectively leverages the local spatial statistical characteristics of testing pixel for target recognition, demonstrating excellent performance compared to other detectors in four real hyperspectral scenes.
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
(2021)
Article
Optics
Jeremy Xuan Yu Chew, Zi Heng Lim, Y. Qi, Guangcan Zhou, Guangya Zhou
Summary: Infrared devices are increasingly used in various applications. This paper introduces a novel dispersive spectrometer that has high-throughput and decoupled spectral resolution. The proposed spectrometer utilizes a two-stage Hadamard transform encoding process to increase the signal-to-noise ratio. With a single-pixel detector, the system can be easily implemented in other desired wavelengths. Additionally, a method is developed to remove the need for uniform illumination and improve the ease of device design for in situ measurement.
Article
Chemistry, Multidisciplinary
Inki Kim, Hongyoon Kim, Seungyeon Han, Joohoon Kim, Yangkyu Kim, Seonghyeon Eom, Aleksandr Barulin, Inhee Choi, Junsuk Rho, Luke P. Lee
Summary: Multiplexed metasurfaces-driven plasmonic resonance energy transfer (PRET) hyperspectral imaging is reported for probing biological light-matter interactions. Pixelated metasurfaces with engineered scattering spectra are designed and applied with three different biomolecules to obtain selective molecular fingerprint imaging.
ADVANCED MATERIALS
(2023)
Article
Geochemistry & Geophysics
Lili Zhang, Baozhi Cheng, Shumei Tan, Yimeng Wang
Summary: The paper proposes a joint adaptive subspace detection model based on fractional Fourier transform (FJASD) for hyperspectral anomaly detection. The FJASD combines spectral and spatial characteristics to improve the performance of AD.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2022)
Article
Chemistry, Analytical
Yan Tan, Jianxing Zhou, Xiaotong Xing, Junren Wang, Jinkun Huang, Huiyu Liu, Jiajie Chen, Mingjie Dong, Qin Xiang, Haifeng Dong, Xueji Zhang
Summary: In this study, the controllable self-assembly of DNA-linked gold nanoparticles (AuNPs) for in vivo biomedical applications was achieved by using programmable DNA tetrahedral structures. Three different sizes of AuNPs (20nm, 10nm, and 5nm) were organized and positioned using this method. The density and arrangement of the satellite AuNPs around the core AuNPs were controlled by tuning the size and amount of DNA tetrahedron functionalized on the core AuNPs, resulting in strong electromagnetic field enhancement. With the conjugation of Raman molecules, strong surface-enhanced Raman scattering photoacoustic imaging signals were generated, allowing for the imaging of microRNA-21 and tumor tissues in vivo. This study provides an efficient strategy for building precision plasmonic superstructures in plasmonic-based bioanalysis and imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
James Ethan Batey, Meek Yang, Hannah Giang, Bin Dong
Summary: In this study, an ultrahigh-throughput spectroscopy and microscopy imaging system was developed to characterize AuNPs at the single-particle level using phasor analysis. The developed method allows quantification of spectra and spatial information of a large number of AuNPs with high temporal resolution and localization precision. Compared to conventional optical grating method, the phasor approach enables high-throughput analysis of single-particle SPR properties in high particle density, demonstrating up to 10-fold greater efficiency.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Yupeng Chen, Jinguang Lv, Wei Yue, Yuanhang Zhao, Yuxin Qin, Jin Tao, Cheng Chen, Weibiao Wang, Jingqiu Liang
Summary: This paper proposes a snapshot infrared imaging Fourier transform spectrometer (SIIFTS) based on stepped micromirrors and a lens array, which can accurately and stably obtain real-time image and spectral information from dynamic targets.
Article
Optics
Ruibiao Miyan, Xueliang Wang, Jie Zhou, Youjun Zeng, Junle Qu, Ho-Pui Ho, Kaiming Zhou, Bruce Zhi Gao, Jiajie Chen, Yonghong Shao
Summary: In this study, a multi-channel phase interrogation detection SPR imaging sensing scheme was successfully designed, which introduced a fixed optical path difference between p- and s-polarized light using a birefringence crystal. This allowed for multi-sample detection without the need for any mechanical moving components.
Article
Optics
Xiangzhe Zhang, Jingping Zhu, Liqing Huang, Yu Zhang, Huimin Wang, Haoxiang Li, Fengqi Guo, Jinxin Deng
Summary: This study introduces a novel channel-modulated static birefringent Fourier transform imaging spectropolarimeter (CSBFTIS) based on a double Wollaston prism (DWP). The spectral resolution can be adjusted by changing an adjustable air gap (AG) in the CSBFTIS. By combining the channel-modulated imaging spectropolarimeter with the slit-free static birefringent Fourier transform imaging spectrometer technology, the CSBFTIS offers adjustable spectral resolution and can greatly reduce the size of spectral image data compared to previous spectropolarimeters.
Article
Optics
Chao-Mao Hsieh, Patricia Yang Liu, Lip Ket Chin, Jing Bo Zhang, Kuan Wang, Kung-Bin Sung, Wee Ser, Tarik Bourouina, Yamin Leprince-Wang, Ai-Qun Liu
Article
Biochemical Research Methods
Chi-Kuang Sun, Pei-Jhe Wu, Sheng-Tse Chen, Yu-Hsiang Su, Ming-LIang Wei, Chiao-Yi Wang, Hao-Cheng Gao, Kung-Bing Sung, Yi-Hua Liao
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Engineering, Electrical & Electronic
Li-Da Huang, Tzu-Chia Kao, Kung-Bin Sung, Jacob A. Abraham
Summary: Brain functions are affected by external stimuli, with Low-Level-Light Therapy using near-infrared photons being effective in modulating hemodynamic activities in the brain. However, the biphasic hormetic dose-response is observed with bioenergetics being stimulated at low doses and inhibited at high doses in all photon stimulations. The amount of photon energy delivered to the brain is influenced by wavelength and the multilayered head structure with variations in optical parameters.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Chemistry, Analytical
Shih-Chung Wei, Chia-Chen Chang, Tsung-Liang Chuang, Kung-Bin Sung, Chii-Wann Lin
Summary: This work presents a plasmonic enhanced digitizing biosensor for rapid detection of nucleic acids. By combining modified loop-mediated isothermal amplification with plasmonic enhancement sensor, the researchers achieved rapid detection of the hepatitis virus. The digitizing plasmonic nanoarray biosensor showed earlier detection compared to conventional sensors and could detect nucleic acid at low concentrations within minutes.
Article
Biochemical Research Methods
Huai-Ching Hsieh, Po-Ting Lin, Kung-Bin Sung
Summary: Investigating the dynamics of cell death at the single-cell level is crucial in biological research. This study developed a label-free technique called quantitative phase imaging (QPI) to quantify the cellular morphology and intracellular mass distribution of cells undergoing apoptosis and necrosis. The results showed that apoptotic and necrotic cells differ from normal cells in terms of phase and nuclear boundary. This method can be applied to studying cells undergoing state transitions such as drug response.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biochemical Research Methods
Ali Afshari, Rolf B. Saager, David Burgos, William C. Vogt, Jianting Wang, Gonzalo Mendoza, Sandy Weininger, Kung-Bin Sung, Anthony J. Durkin, T. Joshua Pfefer
Summary: Clinical studies have shown that epidermal pigmentation can affect cerebral oximetry measurements. Researchers have developed a phantom-based test method to evaluate the impact of skin pigmentation on cerebral oximeter performance. The findings indicate that cerebral oximeter outputs exhibit a consistent decrease in saturation level with simulated melanin content, with the effect being greatest at low saturation levels and most pronounced in neonatal sensors.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Biochemical Research Methods
Tzu-Chia Kao, Kung-Bin Sung
Summary: This study presents an iterative curve fitting method based on Monte Carlo simulation to quantify subject-specific tissue optical properties. The results demonstrate that this method can accurately estimate the optical properties of different tissues in the head.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Physics, Multidisciplinary
Guo-Sheng Lin, Shih-Cheng Tu, Chong-Ian Mok, Tsan-Hsueh Huang, Chi-Hau Chen, Lin-Hung Wei, Kung-Bin Sung
Summary: This study used two-layer forward Monte Carlo models to predict diffuse reflectance and fluorescence intensities of cervical mucosa. The models showed improved accuracy in estimating tissue properties and detecting precancerous changes compared to conventional models. It suggests the potential of fluorescence spectroscopy for detecting precancers in the cervix.
FRONTIERS IN PHYSICS
(2022)
Article
Optics
Shin-Shyang Huang, Yang-Hsien Lin, Shang-Ju Wu, Kung-Bin Sung
Summary: The mass and concentration of hemoglobin per erythrocyte are important hematological parameters. Measuring these parameters requires the value of specific refraction-index increment (RII) of oxy-genated hemoglobin, which diverges in the literature. Refractive indices of hemoglobin solutions are measured directly by digital holographic microscopy and the differences between hemoglobin from thalassemic patients and healthy volunteers are not significant.
Article
Engineering, Electrical & Electronic
Huai-Ching Hsieh, Yi-Ju Lee, Kung-Bin Sung, An-Chi Wei
Summary: Photobiomodulation (PBM) stimulates biological tissues using low-energy light. The effects of PBM vary with light parameters, and mitochondrial responses play a crucial role. Understanding dose-dependent PBM effects, particularly on mitochondrial activity, is essential for optimizing clinical therapies.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Proceedings Paper
Engineering, Biomedical
Guo-Sheng Lin, Chong Ian Mok, Kung-Bin Sung
Summary: A two-step curve fitting process is established to extract intrinsic fluorescence intensity and spectrum of tissue fluorophores, showing that the two-layered tissue model outperforms conventional homogeneous tissue models in extracting tissue optical properties. Intrinsic fluorescence parameters are extracted from in-vivo spectra measured on 31 subjects.
BIOMEDICAL IMAGING AND SENSING CONFERENCE 2021
(2021)
Proceedings Paper
Engineering, Biomedical
Yu-Peng Hsieh, Tzu-Chia Kao, Kung-Bin Sung
Summary: Transcranial photobiomodulation (tPBM) is a new non-invasive intervention that applies red/near-infrared light to the forehead for neuroprotective and neuroenhancement effects. A machine-learning model was proposed in this study to predict the energy distribution of photons reaching the gray matter based on diffuse reflectance and demographic variables.
BIOMEDICAL IMAGING AND SENSING CONFERENCE 2021
(2021)
Proceedings Paper
Engineering, Biomedical
Ying-Ju Tsai, Sunil Vyas, Yuan Luo, Kung-Bin Sung
Summary: This paper presents backscattering Muller matrix calculations for different size of particles based on electric field Monte Carlo simulation, and comparative studies were performed. The results may find important applications in laser tissue interaction.
BIOMEDICAL IMAGING AND SENSING CONFERENCE 2021
(2021)
Article
Biochemical Research Methods
Yang-Hsien Lin, Ken Y-K Liao, Kung-Bin Sung
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Optics
Chiao-Yi Wang, Tzu-Chia Kao, Yin-Fu Chen, Wen-Wei Su, Hsin-Jou Shen, Kung-Bin Sung
