Journal
OPTICS EXPRESS
Volume 18, Issue 26, Pages 27560-27566Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.18.027560
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- National Science Council of the Republic of China [NSC 98-2221-E-155-001]
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The concentration and pH value of the immobilized glucose oxidase (GOD) are critical parameters in a glucose sensor. In this study, we develop a glucose fiber sensor integrated with heterodyne interferometry to measure the phase difference arising from the chemical reaction between glucose and GOD. Our studies show that the response time and resolution of this sensor will be strongly affected by the pH and concentration properties of GOD. In addition, the results show good linearity between the calibration curve for the glucose solution and serum based sample. The response time of this sensor can be shorter than 3 seconds and best resolutions are 0.1 and 0.136 mg/dl for glucose solution and serum based sample, respectively. (C) 2010 Optical Society of America
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