Journal
OPTICS EXPRESS
Volume 17, Issue 20, Pages 17502-17516Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.17.017502
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Funding
- National Institutes of Health [NIH CA-114542]
- National Pancreas Foundation
- Wallace H. Coulter Foundation
- University of Michigan Comprehensive Cancer Center
- University of Michigan Medical School Translational Research Program
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An empirical model was developed to interpret differences in the experimentally measured reflectance and fluorescence spectra of freshly excised human pancreatic tissues: normal, adenocarcinoma, and pancreatitis (inflammation). The model provided the first quantitative links between spectroscopic measurements and histological characteristics in the human pancreas. The reflectance model enabled the first (to our knowledge) extraction of wavelength resolved absorption and reduced scattering coefficients for normal and diseased human pancreatic tissues. The fluorescence model employed reflectance information to extract attenuation free intrinsic endogenous fluorescence spectra from normal pancreatic tissue, pancreatic adenocarcinoma, and pancreatitis. The method developed is simple, intuitive, and potentially useful for a range of applications in optical tissue diagnostics. This approach is potentially applicable to in vivo studies, because it can account for the absorptive effects of blood in tissues. (C) 2009 Optical Society of America
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