Article
Ophthalmology
Roberto dell'Omo, Mariaelena Filippelli, Serena De Turris, Luca Cimino, David H. Steel, Carlos E. Pavesio, Andrea Govetto, Ismael Chehaibou, Francesco Parmeggiani, Mario R. Romano, Lucia Ziccardi, Enza Pirozzi, Ciro Costagliola
Summary: The study aimed to investigate FA findings in eyes with LMH and ERM foveoschisis, revealing that central and peripheral leakage are common in these conditions while perivascular leak and disc hyperfluorescence are less frequently observed. These findings suggest that breakdown of the retinal blood barrier is often associated with these vitreoretinal disorders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Physics, Multidisciplinary
Alessandro Arrigo, Emanuela Aragona, Alessandro Bordato, Alessia Amato, Andrea Saladino, Francesco Bandello, Maurizio Battaglia Parodi
Summary: The study demonstrated that the filling pattern of MNV and blood flow reflectivity features influence the OCTA detection of MNV. There was good agreement between early ICGA and OCTA size for type 1 MNV, with the lesions appearing larger in the late ICGA phase. Type 2 MNV had higher reflectivity and was strongly associated with OCTA's ability to reconstruct the neovascular network.
FRONTIERS IN PHYSICS
(2021)
Article
Ophthalmology
Faruque D. Ghanchi, Corinne Fulcher, Zeid Madanat, Faris Mdanat
Summary: The study demonstrated that OCT-A has high sensitivity and specificity for detecting CNV in treatment-naive nAMD patients, and suggested the potential use of SHRM and DLS as additional biomarkers for diagnosis.
Article
Multidisciplinary Sciences
M. Parravano, L. Ziccardi, E. Borrelli, E. Costanzo, S. Frontoni, F. Picconi, V. Parisi, R. Sacconi, A. Di Renzo, M. Varano, G. Querques
Summary: The study revealed differences in outer retina function and CC perfusion characteristics between NPDR and NoDR T1D patients, with significantly greater flow deficit average area in NPDR eyes compared to NoDR eyes, while mfERG-RADs were similar in both groups. In addition, a positive correlation between outer retina dysfunction and CC impairment was observed in NPDR eyes, while a negative correlation between photoreceptor reflectivity and CC abnormalities was seen in NoDR eyes.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Josef Huemer, Hagar Khalid, Siegfried K. Wagner, Luke Nicholson, Dun Jack Fu, Dawn A. Sim, Praveen J. Patel, Konstantinos Balaskas, Ranjan Rajendram, Pearse A. Keane
Summary: Abnormal retinal neovascularization caused by ischemic retinal vein occlusion (RVO) can lead to visually significant vitreous hemorrhage. Wide-field optical coherence tomography angiography (WF-OCTA) is a useful noninvasive tool for detecting and characterizing neovascularization secondary to RVO in patients.
Article
Ophthalmology
Yun Hsia, Yi-Ting Hsieh
Summary: The morphology of macular retinal vasculature was found to be associated with the severity of idiopathic epiretinal membrane (ERM). Increased average vessel diameter, decreased skeleton density, decreased fractal dimension, and decreased vessel tortuosity were all indicators of more severe ERM and associated visual impairment. These parameters can serve as good indicators for assessing the severity of ERM and its impact on visual function.
Article
Medicine, General & Internal
Pasquale Viggiano, Maria Oliva Grassi, Giacomo Boscia, Mariagrazia Pignataro, Giovanni Petruzzella, Enrico Borrelli, Teresa Molfetta, Giovanni Alessio, Francesco Boscia
Summary: The study explores the morphofunctional fluctuations in eyes treated for neovascular AMD when switching from aflibercept or ranibizumab to brolucizumab. The results showed that brolucizumab treatment improved visual function in patients and resulted in choroidal vascular enlargement and resolution of subretinal and intraretinal fluid.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Federico Corvi, Mariano Cozzi, Alessandro Invernizzi, Lucia Pace, Srinivas R. Sadda, Giovanni Staurenghi
Summary: The study found that OCTA is superior to other imaging modalities in detecting MNV in eyes with macular atrophy, particularly suitable for multimodal imaging evaluation and should be considered in clinical trials.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Rita Serra, Florence Coscas, Jean Francois Boulet, Diogo Cabral, Thi Ha Chau Tran, Giuliana Solinas, Antonio Pinna, Marco Lupidi, Gabriel Coscas
Summary: The study aimed to analyze the relationship between visual outcome and anatomic changes detected by traditional multimodal retinal imaging and OCTA in DME eyes under treatment with Aflibercept. The results showed significant improvement in visual acuity and central macular thickness with Aflibercept treatment. Multimodal retinal imaging, along with fractal OCTA analysis, may provide useful biomarkers for predicting visual outcome in DME.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Bilal Haj Najeeb, Gabor G. Deak, Stefan Sacu, Ursula Schmidt-Erfurth, Bianca S. Gerendas
Summary: This study reported on the morphological characteristics and regional distribution of multifocal macular neovascularization type 3 (mMNV3), revealing specific morphological and topographical features of this variant. Multimodal imaging is helpful in understanding the pathomorphological condition in more detail.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
David Holomcik, Philipp Seeboeck, Bianca S. Gerendas, Georgios Mylonas, Bilal Haj Najeeb, Ursula Schmidt-Erfurth, Gabor Deak
Summary: In this study, a deep learning-based algorithm was developed to automatically segment lesion size and leakage area on fluorescein angiography (FA) images in patients with neovascular age-related macular degeneration (nAMD). The algorithm achieved human-level performance in CNV lesion segmentation and was well-received in clinical applicability testing, demonstrating its potential for improving objective biomarker analysis in FA images for clinical application.
Article
Ophthalmology
Matt Trinh, Michael Kalloniatis, Lisa Nivison-Smith
Summary: The study using high-density OCTA cluster analysis revealed specific retinal vascular changes in iAMD patients, showing significantly decreased vessel perfusion in both superficial and deep vascular complexes, with nonuniform changes observed in the superficial vascular complex. This may support the presence of anterograde transsynaptic degeneration in iAMD.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Andrea M. Coppe, Giuliana Lapucci, Guido Ripandelli, Francesca R. Pesci, Luca Buzzonetti, Giancarlo Iarossi
Summary: The study found that in patients with unilateral idiopathic epiretinal membrane, fellow eyes showed significantly reduced ganglion cell layer thickness and vessel density in the superficial capillary plexus. These results suggest that a vascular defect in the superficial capillary plexus may lead to cellular loss in the inner retina, contributing to the proliferation of epiretinal membrane.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Rossella D'Aloisio, Paolo Carpineto, Agbeanda Aharrh-Gnama, Carla Iafigliola, Luca Cerino, Marta Di Nicola, Annamaria Porreca, Lisa Toto, Rodolfo Mastropasqua
Summary: This observational comparative study using WSS-OCTA examined early retinal vascular and functional changes in patients undergoing vitreoretinal surgery for iERM or MH. The study found significant increases in PD of SCP and DCP postoperatively in both groups, indicating potential for monitoring and predicting surgery outcomes.
Article
Medicine, General & Internal
Thibaud Mathis, Sarra Dimassi, Olivier Loria, Aditya Sudhalkar, Alper Bilgic, Philippe Denis, Pierre Pradat, Laurent Kodjikian
Summary: The study revealed that retinal vascular changes occur in patients with exudative AMD, with the IRF +/- SRF group showing significantly lower MPD and MVD in the SCP and DCP compared to the healthy group at T0, although there was an increase at T1 but still lower than the healthy group. The SRF group had significantly lower MPD and MVD in the DCP compared to the healthy group at T0.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Varo Kirthi, Paul Nderitu, Uazman Alam, Jennifer Evans, Sarah Nevitt, Rayaz A. Malik, Timothy L. Jackson
Summary: This study protocol presents a systematic review and meta-analysis of retinopathy in prediabetes to estimate the prevalence in adults with prediabetes. Pooled estimates will be calculated using random effects meta-analytic techniques, and findings will be disseminated through peer-reviewed publications and conference presentations.
Article
Ophthalmology
Yacine Troumani, Sara Touhami, Timothy L. Jackson, Camila V. Ventura, Dinu Michel Stanescu-Segall, Marie-Helene Errera, Dominique Rousset, Bahram Bodaghi, Guilhem Cartry, Thierry David, Laurence Beral
Summary: This study found that almost half of patients with systemic Zika virus infection presented with red eyes and anterior uveitis, with a significant proportion experiencing persistently increased intraocular pressure. Ophthalmic evaluation should be considered in patients with red eye and acute Zika infection to potentially detect and manage hypertensive anterior uveitis.
JAMA OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Timothy L. Jackson, Julia Haller, Koenraad H. Blot, Luc Duchateau, Benedicte Lescrauwaet
Summary: This study systematically reviewed the effects of Ocriplasmin on VMT and investigated the impact of baseline covariates on the outcomes. The results showed that Ocriplasmin can promote VMAR and MH closure, reduce the need for vitrectomy, and improve BCVA. However, Ocriplasmin treatment may cause transient visual impairment and other adverse events.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Nishanthan Srikantha, Yurema Teijeiro-Gonzalez, Andrew Simpson, Naba Elsaid, Satyanarayana Somavarapu, Klaus Suhling, Timothy L. Jackson
Summary: This study investigated the viscosity of porcine vitreous and the diffusion of macromolecules using the fluorescence recovery after photobleaching (FRAP) method. The results showed that FRAP is a feasible and practical optical method to quantify macromolecular diffusion through the vitreous.
Article
Medicine, Research & Experimental
Timothy L. Jackson, Catey Bunce, Riti Desai, Jost Hillenkamp, Chan Ning Lee, Noemi Lois, Tunde Peto, Barnaby C. Reeves, David H. Steel, Rhiannon T. Edwards, Jan C. van Meurs, Hatem Wafa, Yanzhong Wang
Summary: This study aims to compare different treatment methods for submacular hemorrhage (SMH) to determine the best management approach. The study uses a randomized controlled surgical trial design, dividing participants into two groups receiving different treatment regimens, and evaluates the efficacy and safety through measures such as visual acuity and visual function.
Article
Ophthalmology
Timothy L. Jackson, Cristina Soare, Caroline Petrarca, Andrew Simpson, James E. Neffendorf, Robert Petrarca, Katherine Alyson Muldrew, Tunde Peto, Usha Chakravarthy, Luke Membrey, Richard Haynes, Mark Costen, David H. W. Steel, Riti Desai
Summary: This study assessed the long-term safety and efficacy of epimacular brachytherapy (EMB) for chronic neovascular age-related macular degeneration (nAMD). The results showed that EMB did not reduce the number of injections and was associated with worse visual acuity compared to anti-VEGF monotherapy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Varo Kirthi, Benjamin P. Zuckerman, Uazman Alam, Catey Bunce, David Hopkins, Timothy L. Jackson
Summary: The purpose of this study was to explore the association between progressive dysglycemia and retinal neurodegeneration. A cross-sectional study was conducted on 68 participants, and it was found that as dysglycemia increased, the macular thickness decreased. The urinary albumin-to-creatinine ratio was significantly correlated with macular thinning. Waist circumference, body mass index, blood pressure, lipid profile, and insulin resistance showed no association with macular thinning. Therefore, retinal neurodegenerative changes can help identify those most at risk from dysglycemic end-organ damage.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Review
Ophthalmology
Varo Kirthi, Paul Nderitu, Uazman Alam, Jennifer R. Evans, Sarah Nevitt, Rayaz A. Malik, David Hopkins, Timothy L. Jackson
Summary: This study aimed to determine the prevalence of retinopathy in adults with prediabetes. The results showed a wide range of prevalence estimates, indicating significant variation across different studies due to differences in screening methods, grading protocols, and study populations.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Paul Nderitu, Joan M. Nunez do Rio, Ms Laura Webster, Samantha S. Mann, David Hopkins, M. Jorge Cardoso, Marc Modat, Christos Bergeles, Timothy L. Jackson
Summary: This study developed and validated deep learning models for automated curation of diabetic retinopathy (DR) screening images. The results showed that the models effectively detected the laterality, retinal presence, retinal field, and gradability of the images, with generalization between different centers and populations.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Varo Kirthi, Kate I. Reed, Komeil Alattar, Benjamin P. Zuckerman, Catey Bunce, Paul Nderitu, Uazman Alam, Bronagh Clarke, Scott Hau, Fatima Al-Shibani, Ioannis N. Petropoulos, Rayaz A. Malik, Theodoros Pissas, Christos Bergeles, Prashanth Vas, David Hopkins, Timothy L. Jackson
Summary: The aim of this study was to investigate whether novel non-invasive diagnostic technologies can identify early small nerve fibre and retinal neurovascular pathology in prediabetes. The results showed that abnormal retinal neurovascular structure and function may precede retinopathy in prediabetes, which is different from the diagnosis of retinopathy based on fundus examination.
Review
Medicine, General & Internal
Uazman Alam, Matthew Anson, Yanda Meng, Frank Preston, Varo Kirthi, Timothy L. Jackson, Paul Nderitu, Daniel J. Cuthbertson, Rayaz A. Malik, Yalin Zheng, Ioannis N. Petropoulos
Summary: Corneal confocal microscopy is a non-invasive imaging technique used in ophthalmology for diagnosing corneal disorders, as well as detecting nerve damage in peripheral neuropathies and central neurodegenerative diseases. Artificial intelligence, particularly deep learning algorithms, can analyze the images and assist in quantifying nerve parameters. The application of AI has the potential to improve the diagnostic and prognostic utility of this technique.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Heidi Laviers, Evangelia Papavasileiou, Charlotte Bruce, Laura Maubon, Meera Radia, Nikolaos Dervenis, Benjamin Zuckerman, Graeme K. K. Loh, Olga Theodorou, Abdel Douiri, Hadi Zambarakji, Teresa Sandinha, David H. H. Steel, Varo Kirthi, Cordelia McKechnie, Rahila Zakir, Graham Duguid, Timothy L. L. Jackson
Summary: The purpose of this study was to assess the effect of ethnicity on surgical macular hole closure. A retrospective cohort study was conducted in five UK National Health Service Hospitals, and the results showed that Black ethnicity is associated with an approximately twofold greater risk of failed FTMH surgery, highlighting the need for further investigation into the reasons for this difference.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Timothy L. Jackson, Jason Slakter, Marc Buyse, Kun Wang, Pravin U. Dugel, Charles C. Wykoff, David S. Boyer, Michael Gerometta, Megan E. Baldwin, Clare F. Price
Summary: This study tested the efficacy and safety of OPT-302 in combination with ranibizumab for the treatment of wet age-related macular degeneration. The results showed that the combination therapy with OPT-302 2.0 mg significantly improved visual acuity compared to the standard of care, with favorable safety.
Article
Transplantation
James E. Neffendorf, Tracey Mare, Andrew R. H. Simpson, Cristina Soare, Varo Kirthi, Claire C. Sharpe, Timothy L. Jackson
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Robin Jacquot, Pascal Seve, Timothy L. Jackson, Tao Wang, Antoine Duclos, Dinu Stanescu-Segall
Summary: In recent years, artificial intelligence (AI) has been applied in diagnostic decision support systems. This literature review focuses on the use of AI in determining the diagnosis, classification, and underlying etiology of uveitis. AI-based systems show promising performance, with a classification accuracy of 93-99% and a sensitivity of at least 80%. However, there are limitations such as retrospective data collection, missing data, and the lack of reliable integration of ophthalmic, demographic, clinical, and ancillary tests. Further research is needed to incorporate comprehensive clinical data and larger patient populations to improve AI-based diagnostic tools for uveitis management.
JOURNAL OF CLINICAL MEDICINE
(2023)