Letter
Dermatology
C. Zengarini, M. Roda, C. Schiavi, F. Bruni, F. Bardazzi, C. Bellusci, B. Raone
Summary: A clinical case of an atopic patient with severe manifestations impacting quality of life at the cutaneous and ocular site is reported. Conventional treatments were ineffective and omalizumab had to be used to successfully treat the disease.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Health Care Sciences & Services
Samim Azizi, Yousif Subhi, Marie Louise Roed Rasmussen
Summary: This systematic review examined the surgical treatment methods and effects of shield ulcers in VKC. The results showed that almost all patients experienced resolution or improvement of their ulcers regardless of the surgical approach. However, there is a risk of recurrence and potential side effects, highlighting the importance of careful post-operative treatment and follow-ups.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Ishin Ninomiya, Kenji Yamatoya, Keitaro Mashimo, Akira Matsuda, Ayumi Usui-Ouchi, Yoshihiko Araki, Nobuyuki Ebihara
Summary: This study investigated the role of oncostatin M (OSM) in vernal keratoconjunctivitis (VKC). The results showed that OSM induced epithelial barrier dysfunction and IL-33 production in VKC, playing important roles in severe and prolonged allergic inflammation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, General & Internal
Minjie Chen, Bilian Ke, Jun Zou, Lan Gong, Yan Wang, Chaoran Zhang, Jianjiang Xu, Anji Wei, Jiaxu Hong
Summary: Both the isolated use of fluorometholone and combined use of azelastine and fluorometholone are effective in alleviating the signs and symptoms of severe ACD, but optimal response can be achieved with adjunctive treatment including azelastine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jodhbir S. Mehta, Wei-Li Chen, Arthur C. K. Cheng, Le Xuan Cung, Ivo J. Dualan, Ramesh Kekunnaya, Nurliza Khaliddin, Tae-Im Kim, Douglas K. Lam, Seo Wei Leo, Florence Manurung, Nattaporn Tesavibul, Dominique Bremond-Gignac
Summary: Vernal keratoconjunctivitis (VKC) is an underdiagnosed ocular surface disease in Asia, with limited epidemiological data. It has a significant impact on patients' quality of life and can even lead to vision loss. The management and treatment of VKC varies across Asia, and there is a lack of precise diagnostic criteria and effective treatments. To address this issue, the Management of Vernal Keratoconjunctivitis in Asia (MOVIA) Expert Working Group developed best-practice recommendations based on available evidence and clinical expertise.
FRONTIERS IN MEDICINE
(2022)
Review
Allergy
Gaia Bruschi, Daniele Giovanni Ghiglioni, Laura Cozzi, Silvia Osnaghi, Francesco Viola, Paola Marchisio
Summary: Vernal keratoconjunctivitis (VKC) is a chronic eye condition that affects both the cornea and the conjunctiva and is commonly seen in young individuals. It is characterized by symptoms such as itching, photophobia, discharge, tearing, foreign body sensation, and corneal ulcers. The diagnosis of VKC is based on clinical evaluation, as no specific biomarkers have been identified. Treatment options include various types of medications, ranging from antihistamines and steroids to cyclosporine and tacrolimus eye drops. Surgical intervention may be required in rare cases to treat ulcers or complications caused by long-term use of steroid eye drops. This systematic literature review provides a comprehensive overview of diagnostic methods, management strategies, and available treatments for VKC.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Ophthalmology
Akira Hirota, Jun Shoji, Noriko Inada, Yukiko Shiraki, Satoru Yamagami
Summary: Treatment with topical tacrolimus ophthalmic suspension for VKC and AKC leads to clinical improvement and stable stages of the diseases. The remission rates increase over time and the need for concomitant administration of steroid eye drops decreases with age. Cluster analysis helps to categorize patients into different subgroups for better understanding of disease characteristics.
Article
Ophthalmology
Smruti Rekha Priyadarshini, Sujata Das
Summary: Management of allergic eye disease is often challenging and lacks a straightforward approach. This online survey aimed to gather opinions from ophthalmologists regarding the preferred treatment patterns for allergic eye disease. The results provided insights into the clinical experience and treatment preferences of ophthalmologists in different scenarios, offering valuable guidance for managing this common and bothersome disease.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Allergy
Angela Messina, Angelo Palmigiano, Claudia Tosto, Donata Agata Romeo, Luisa Sturiale, Domenico Garozzo, Andrea Leonardi
Summary: The study aimed to investigate tear fluid N-Glycome from patients with VKC and AKC to identify specific changes and potential glyco-biomarkers. Three distinct patterns for CTRL, VKC, and AKC patients were identified in terms of relative intensities for some N-glycans structures, with major variations involving bisecting and hyperfucosylated glycoforms. The tear MS profiles showed rich specific glycoforms, particularly with high fucosylation degree, providing important information for a better understanding of VKC and AKC alterations at the molecular level.
Article
Ophthalmology
Srujana Dubbaka, Mohini Agrawal, Alok Sati, Sumedha Vats, Saurabh Mahajan
Summary: This study evaluated the presence of perilimbal pigmentation in Indian patients with vernal keratoconjunctivitis (VKC) and found that it was present in a significant number of cases.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Anuradha Pradhan, Sabyasachi Pattanayak, Jayashree Dora, Praveen Subudhi
Summary: This study evaluated the effectiveness of a modified therapeutic protocol for VKC based on Bonini grading system. The results showed significant improvement in symptoms and reduced recurrence rates after following the treatment protocol.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Srujana Dubbaka, Mohini Agrawal, Alok Sati, Sumedha Vats, Saurabh Mahajan
Summary: The purpose of this study was to evaluate the presence of perilimbal pigmentation (PLP) in Indian patients with vernal keratoconjunctivitis (VKC). The study found that 81 cases (53.29%) of VKC patients had characteristic PLP, with 15 cases (18.5%) showing pigmentation in all four quadrants. The study concluded that PLP is a common finding in VKC cases.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Allergy
Serge Doan, Nikolaos G. Papadopoulos, Jason K. Lee, Salvatore Leonardi, Sara Manti, Susanne Lau, Carmen Rondon, Vibha Sharma, Uwe Pleyer, Xavier Jaumont, Slawomir B. Lazarewicz
Summary: Vernal keratoconjunctivitis (VKC) is a severe ocular allergic disease that mainly affects children and is more common in warm and humid regions. Inadequately treated VKC can lead to severe complications and corneal damage. Studies have shown that IgE-mediated and non-IgE-mediated mechanisms are involved in the pathophysiology of VKC.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Allergy
Dai Miyazaki, Atsuki Fukushima, Eiichi Uchio, Jun Shoji, Kenichi Namba, Nobuyuki Ebihara, Etsuko Takamura, Ken Fukuda, Akira Matsuda, Shigeki Okamoto, Kazumi Fukagawa, Hiroshi Fujishima, Shigeaki Ohno, Yuichi Ohashi
Summary: This article summarizes the third edition of the Japanese guidelines for allergic conjunctival diseases, outlining the diagnosis, pathogenesis, and treatment of ACD, with a focus on the use of steroids and immunosuppressive drugs. This knowledge will assist healthcare providers and patients in making informed decisions regarding treatment.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Ophthalmology
Fabiana Mallone, Marco Marenco, Rosalia Giustolisi, Rocco Plateroti, Alessandro Lambiase
Summary: This case report describes the successful treatment of persistent corneal epithelial defect in a patient with total limbal stem cell deficiency (LSCD) after severe firework-related ocular burn using autologous Platelet-Rich Plasma (PRP). The findings provide valuable information on the management of ocular burns, supporting the use of PRP in preventing corneal stromal melting and promoting epithelial coverage.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Letter
Genetics & Heredity
Fabiana Mallone, Luca Lucchino, Sandra Giustini, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis Type 1 (NF1) is a rare neurocutaneous disorder mainly affecting the nervous system, eye, and skin. Recent studies have found that choroidal abnormalities are frequently present in NF1 and have been added to the diagnostic criteria.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Ophthalmology
Stefano Bonini, Andrea Leonardi
Summary: Ocular allergy is a common eye disease with multiple factors influencing its development. Treatment should be holistic, dynamic, and personalized.
Article
Biochemistry & Molecular Biology
Magda Gharbiya, Giacomo Visioli, Alessandro Trebbastoni, Giuseppe Maria Albanese, Mayra Colardo, Fabrizia D'Antonio, Marco Segatto, Alessandro Lambiase
Summary: We conducted a study to evaluate the diagnostic role of AD biomarkers in tears and their association with retinal and choroidal microstructures. We found that tear A beta 1-42 levels had a high sensitivity and specificity in detecting MCI and AD patients. Additionally, A beta 1-42 levels were correlated with psychometric scores and choroidal thickness. Testing A beta 1-42 levels in tears could be a minimally invasive and cost-saving method for early detection and diagnosis of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alice Bruscolini, Angela Iannitelli, Marco Segatto, Pamela Rosso, Elena Fico, Marzia Buonfiglio, Alessandro Lambiase, Paola Tirassa
Summary: This study investigated the correlation between the expression levels of NGF and BDNF in tears and serum and ophthalmic and psycho-cognitive symptoms in Graves' Orbitopathy (GO) patients. The results showed that NGF and BDNF expression correlated with ophthalmic symptoms, while mature/precursor NGF and BDNF correlated with psycho-cognitive variables. This study is the first to suggest that changes in NGF and BDNF processing in tears and serum may be associated with ocular and cognitive alterations in GO patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Anna Maria Comberiati, Ludovico Iannetti, Raffaele Migliorini, Marta Armentano, Marika Graziani, Luca Celli, Anna Zambrano, Mauro Celli, Magda Gharbiya, Alessandro Lambiase
Summary: This study aims to evaluate ocular motility (OM) abnormalities associated with Ehlers-Danlos Syndrome (EDS). Patients with EDS underwent a complete orthoptic examination, and various OM alterations were observed in these patients. The results show that superior and medial rectus muscle hypofunction, as well as other abnormalities, are common in patients with EDS.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Alice Bruscolini, Giacomo Visioli, Marco Marenco, Veronica Cherubini, Anna Maria Comberiati, Gaspare Palaia, Massimo Ralli, Livia Ottolenghi, Alessandro Lambiase, Antonella Polimeni
Summary: Italy serves as a gateway for refugees and migrants entering Europe, with a significant number requiring socio-economic and health assistance. A new intervention strategy, known as the PROTECT project, aimed to evaluate the eye health of vulnerable applicants and international protection holders in the head-neck area. 3023 migrants participated in the project, with demographic factors and eye history collected through a questionnaire. Results showed a high prevalence of vision impairment, with various ocular diseases identified. The PROTECT project improves accessibility to preventive care for head-neck diseases and highlights the importance of early identification and prevention of ocular diseases in disadvantaged populations.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Valeria Iannucci, Priscilla Manni, Giulia Mecarelli, Sara Giammaria, Francesca Giovannetti, Alessandro Lambiase, Alice Bruscolini
Summary: Uveitic glaucoma (UG) is a common cause of secondary glaucoma in pediatric ophthalmology, caused by intraocular inflammation. Managing UG is challenging and requires a multidisciplinary approach. Overlap with steroid-induced glaucoma (SIG) is common, and there are limited papers discussing the treatment options for pediatric UG.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Marta Armentano, Luca Lucchino, Ludovico Alisi, Antonio Valerio Chicca, Valerio Di Martino, Emanuele Miraglia, Ludovico Iannetti, Anna Maria Comberiati, Sandra Giustini, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 2 (NF2) is a genetically determined tumor-predisposing syndrome with ocular manifestations including cataracts, epiretinal membranes, retinal hamartomas, optic disk gliomas, and optic nerve sheath meningiomas. Other indirect signs such as optic disk edema, optical atrophy, motility disorders, pupil and lid dysfunction, and neurotrophic keratitis can also be observed.
APPLIED SCIENCES-BASEL
(2023)
Article
Ophthalmology
Annegret Dahlmann-Noor, Stefano Bonini, Dominique Bremond-Gignac, Steffen Heegaard, Andrea Leonardi, Jesus Montero, Eduardo D. Silva
Summary: The EUR-VKC Group has provided guidelines for the assessment, diagnosis, management, referral, and follow-up of VKC patients in order to improve outcomes. They emphasize the importance of timely diagnosis and treatment initiation, and suggest managing VKC according to disease severity.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Marco Coassin, Alessandro Arrigo, Federico Ricci, Raffaella Rosa, Roberto Gattegna, Alessandro Pupino, Jose Manuel Benitez Del Castillo, Stefano Bonini
Summary: The technological breakthroughs in mini-invasive vitreo-retinal surgery have improved the perioperative management and outcomes for millions of patients. Common procedures include vitrectomy, episcleral surgery, intravitreal injections, and laser photocoagulation. Postoperative side effects may include ocular surface disbalance and discomfort symptoms.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eustachio Attico, Giulia Galaverni, Andrea Torello, Elisa Bianchi, Susanna Bonacorsi, Lorena Losi, Rossella Manfredini, Alessandro Lambiase, Paolo Rama, Graziella Pellegrini
Summary: Total bilateral Limbal Stem Cell Deficiency is a pathological condition caused by the loss of corneal stem cells. Cultivated oral mucosa epithelial transplantation (COMET) is the only successful autologous treatment, but it often leads to abnormal corneal vascularization. This study identified a new marker, Paired Like Homeodomain 2 (PITX2), that distinguishes transplanted oral tissue from other epithelia, and also discovered differential expression of angiogenesis-related factors in the three epithelia, providing insights into the neovascularization mechanism in COMET-treated patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fabiana Mallone, Ludovico Alisi, Luca Lucchino, Valerio Di Martino, Marcella Nebbioso, Marta Armentano, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 1 (NF1) is a rare genetic disorder that affects the skin, nervous system, and eyes. Ocular diagnostic hallmarks of NF1 include various abnormalities in the eyes such as nodules, neurofibromas, and spots. Recent advancements in imaging techniques have allowed for better characterization of these eye abnormalities in NF1 patients. This paper reviews the latest progress in understanding and diagnosing choroidal and retinal abnormalities in NF1 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Valeria Iannucci, Priscilla Manni, Ludovico Alisi, Giulia Mecarelli, Alessandro Lambiase, Alice Bruscolini
Summary: Ocular trauma is a common problem worldwide and can lead to secondary glaucoma. Angle recession, usually unilateral, is a major cause of post-traumatic glaucoma after blunt eye trauma. This paper investigates the possible causes of bilateral angle recession and presents a case of chronic post-traumatic glaucoma, possibly caused by an airbag.
Letter
Ophthalmology
Alessandro Lambiase, Fabiana Mallone, Marta Sacchetti, Marco Segatto, Mayra Colardo, Valerio Di Martino, Alice Bruscolini