Article
Ophthalmology
Christopher A. Girkin, Akram Belghith, Christopher Bowd, Felipe A. Medeiros, Robert N. Weinreb, Jeffrey M. Liebmann, James A. Proudfoot, Linda M. Zangwill, Massimo A. Fazio
Summary: The study aimed to determine if the rate of change in the depth of the surface of the lamina cribrosa due to glaucomatous remodeling differs between glaucoma patients of African descent (AD) and European descent (ED). After adjusting for baseline characteristics, it was found that the ED group had significantly greater ALCSD posterior migration compared to the AD group.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Palaiologos Alexopoulos, Yoav Glidai, Zeinab Ghassabi, Bo Wang, Behnam Tayebi, Anse Vellappally, Mengfei Wu, Mengling Liu, Katie Lucy-Jones, Ronald Zambrano, Hiroshi Ishikawa, Joel S. Schuman, Gadi Wollstein
Summary: The purpose of this study was to investigate the deformation of pore paths in the lamina cribrosa (LC) under different intraocular pressure (IOP) and intracranial pressure (ICP) conditions. The results showed that the tortuosity of pore paths varied among different eyes and changed when manipulating IOP or ICP. These findings suggest that the tortuosity of pore paths may be associated with glaucoma susceptibility.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Soo-Ji Jeon, Hae-Young Lopilly Park, Chan-Kee Park
Summary: The study aimed to investigate the association of decreased vessel density in the deep peripapillary region with structural features of the lamina cribrosa. Results showed that eyes with deep vessel density defects in the peripapillary region had thinner lamina cribrosa, and the area with deep vessel density defects had thinner and deeper lamina cribrosa compared to other areas.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Erfan Noury, Suria S. Mannil, Robert T. Chang, An Ran Ran, Carol Y. Cheung, Suman S. Thapa, Harsha L. Rao, Srilakshmi Dasari, Mohammed Riyazuddin, Dolly Chang, Sriharsha Nagaraj, Clement C. Tham, Reza Zadeh
Summary: The study developed a 3D deep learning algorithm for glaucoma detection using SD-OCT ONH cube scans and validated its performance on diverse datasets from different countries and on cropped images. The results showed that the model can accurately distinguish glaucoma from normal cases, with the lamina cribrosa playing an important role in glaucoma detection.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Review
Ophthalmology
Alice Paulo, Pedro G. Vaz, Danilo Andrade De Jesus, Luisa Sanchez Brea, Jan Van Eijgen, Joao Cardoso, Theo van Walsum, Stefan Klein, Ingeborg Stalmans, Joao Barbosa Breda
Summary: The lamina cribrosa (LC) is an active structure that can respond to strain by altering its morphology, with abnormal changes often associated with certain pathologies such as glaucoma. Recent advances in optical coherence tomography (OCT) have allowed for detailed in vivo studies on LC characteristics, particularly in the field of glaucoma management. While LC depth and thickness are the most studied features, further research is needed to fully understand the potential diagnostic and prognostic value of LC features in various diseases.
JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Maria A. Guzman Aparicio, Teresa C. Chen
Summary: This review summarizes the literature on the advancements of three-dimensional (3D) technology in ophthalmology, along with the quantitative methods associated with it, and how they have improved the ability to detect glaucoma disease progression.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Do-Young Park, Hoon Noh, Changwon Kee, Jong-Chul Han
Summary: This study aimed to investigate the topographic relationships among the deep optic nerve head (ONH) parameters representing myopic axial elongation or changes in the lamina cribrosa (LC) in patients with primary open-angle glaucoma (POAG). The study found that the AL-related parameters showed a strong spatial correspondence with glaucomatous ONH damage, whereas the LC-related parameter had less correlation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Computer Science, Interdisciplinary Applications
Rita Marques, Danilo Andrade De Jesus, Joao Barbosa-Breda, Jan Van Eijgen, Ingeborg Stalmans, Theo van Walsum, Stefan Klein, Pedro G. Vaz, Luisa Sanchez Brea
Summary: This review summarizes the latest technology applications of automatic segmentation of the optic nerve head (ONH) in optical coherence tomography (OCT), pointing out the lack of consensus on segmented regions, extracted parameters, and validation methods, highlighting the importance of establishing standardized methods. Only with a concrete set of guidelines, these automatic segmentation algorithms can enter clinical practice.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
ByungKun Lee, Sunhong Jeong, Joosung Lee, Tae Shik Kim, Boy Braaf, Benjamin J. J. Vakoc, Wang-Yuhl Oh
Summary: This work demonstrates 3D depth-invariant cellular-resolution imaging of the living human retina over a 3 x 3 mm field of view using the first intrinsically phase-stable multi-MHz retinal swept-source OCT and novel computational methods. It provides wide-field 3D cellular-resolution imaging in the human retina, which can bring a great impact in clinical ophthalmology.
Article
Multidisciplinary Sciences
Sooyeon Choe, Mirinae Jang, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
Summary: This study investigated the diagnostic utility of three-dimensional neuroretinal rim thickness (3D-NRRT) in distinguishing patients with superior segmental optic nerve hypoplasia (SSOH) from normal-tension glaucoma (NTG). The results showed that 3D-NRRT can be useful in differentiating SSOH from NTG, particularly in certain clock-hour sectors. However, retinal nerve fiber layer thickness (RNFLT) may be more appropriate for distinguishing the two conditions in other sectors.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Yong Woo Kim, Jin Ju Choi, Michael J. A. Girard, Jean Martial Mari, Dong Gyu Choi, Ki Ho Park
Summary: During axial elongation in childhood, changes in temporal border tissue configuration, BMO enlargement, and nasal peripapillary tissue elevation show a significant correlation with changes in AXL.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Anoop Sainulabdeen, Yoav Glidai, Mengfei Wu, Mengling Liu, Palaiologos Alexopoulos, Hiroshi Ishikawa, Joel S. Schuman, Gadi Wollstein
Summary: This study characterized the structure of the lamina cribrosa (LC) in healthy non-human primates (NHPs) using spectral-domain optical coherence tomography (OCT). The results showed regional differences in the thickness of the LC in the central and peripheral regions, as well as in the superior and inferior quadrants. The anterior LC had smaller beams and pores compared to the middle and posterior lamina.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
You Na Kim, Joong Won Shin, Yu Jeong Park, Joo Yong Lee, June Gone Kim, Young Hee Yoon, Yoon Jeon Kim
Summary: In patients with CRVO, pre-existing glaucoma was associated with poorer visual and anatomical outcomes, and played as a significant risk factor for the development and conversion to ischaemic CRVO with lower vision and presence of DRIL at early phase of CRVO.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Yoav Glidai, Katie A. Lucy, Joel S. Schuman, Palaiologos Alexopoulos, Bo Wang, Mengfei Wu, Mengling Liu, Jonathan P. Vande Geest, Hirut G. Kollech, TingFang Lee, Hiroshi Ishikawa, Gadi Wollstein
Summary: This study investigated the in vivo microstructural deformation within the lamina cribrosa volume in response to acute intraocular pressure (IOP) modulation while maintaining fixed intracranial pressure (ICP). Results showed that only half of the eyes exhibited deformation in the lamina cribrosa, and the location of maximum deformation varied between eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Hun Jae Won, Kyung Rim Sung, Joong Won Shin, Youn Hye Jo, Min Kyung Song
Summary: This study found that the lamina cribrosa curvature index is generally higher at different angles in PXG and POAG eyes, with PXG eyes having steeper LC curvature compared to POAG eyes. Additionally, it was revealed that average LCCI and age are factors associated with the presence of PXG.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)