Article
Ophthalmology
Damian Jaggi, Yasmin Solberg, Chantal Dysli, Joel Lincke, Oussama Habra, Sebastian Wolf, Martin Zinkernagel
Summary: The aim of this study was to evaluate whether macular fluorescence lifetimes can serve as predictors for long-term outcomes in macula-off rhegmatogenous retinal detachment. The study found that lifetimes of the detached retinas were prolonged compared to the healthy fellow eyes, and shorter lifetimes were associated with better visual acuity improvement and good final visual acuity.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Medicine, General & Internal
Anita Lyssek-Boron, Adam Wylegala, Katarzyna Krysik, Dominika Janiszewska-Bil, Edward Wylegala, Beniamin Oskar Grabarek, Dariusz Dobrowolski
Summary: This study investigated the changes in retinal capillary plexuses in patients after PPV for RRD treatment. It found changes in the FAZ of both the SCP and DCP in RRD patients, affecting the neurosensory retina and thickness of the retinal nerve fiber layer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Stewart R. Lake, Murk J. Bottema, Keryn A. Williams, Tyra Lange, Karen J. Reynolds
Summary: This study used irregularities in retinal shape from optical coherence tomography (OCT) images as a biomarker for retinal detachment and developed a classifier to identify retinal detachment eyes. The results showed that the classifier had a moderate accuracy in identifying retinal detachment eyes.
OPHTHALMOLOGY AND THERAPY
(2023)
Review
Medicine, General & Internal
Carla Danese, Paolo Lanzetta
Summary: Rhegmatogenous retinal detachment is a serious condition that can cause vision loss, but optical coherence tomography (OCT) provides valuable insights for diagnosis and treatment. Various OCT applications can yield important data, some of which may serve as potential biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Navid Johannigmann-Malek, Stephen B. Kaye, Shadi Badawood, Mathias Maier, Carmen Baumann
Summary: Preoperative posturing is an effective measure to prevent progression of macular detachment in macula-off retinal detachment.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Takeshi Iwase, Ryo Tomita, Eimei Ra, Chie Iwase, Hiroko Terasaki
Summary: The presence of intraretinal cystoid cavities (ICCs) is associated with anterior protrusion in eyes with macula-off rhegmatogenous retinal detachment (RRD), affecting preoperative function and morphology but not postoperative outcomes.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Julian E. Klaas, Philip Rechl, Nikolaus Feucht, Jakob Siedlecki, Julia Friedrich, Chris P. Lohmann, Mathias Maier
Summary: This study proposes an ETDRS grid-based classification for MIRD and identifies biomarkers associated with favorable postoperative outcomes in eyes with center involving retinal detachment (CIRD). Results show that the functional outcome after MIRD may be worse in the presence of foveal involvement, but a lower grade of detachment and the absence of intraretinal edema can predict a good recovery in spite of CIRD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Stewart R. Lake, Murk J. Bottema, Tyra Lange, Keryn A. Williams, Karen J. Reynolds
Summary: Irregularities in retinal shape were found to be associated with axial length, and the irregularity of the mid-peripheral retina can identify eyes that have experienced a retinal detachment. Peripheral retinal irregularity is a better biomarker for retinal detachment than axial length.
BIOENGINEERING-BASEL
(2023)
Article
Ophthalmology
Dallin C. Milner, Christopher Le, Alejandro Marin, Jesse M. Smith, Niranjan Manoharan
Summary: This study evaluates the chronic macula-off retinal detachment (RD) with posterior vitreous detachment (PVD) and finds that these patients have lower rates of initial reattachment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Carmen Baumann, Ahmed Almarzooqi, Navid Johannigmann-Malek, Mathias Maier, Stephen Kaye
Summary: This study aimed to investigate the impact of subfoveal fluid height (SFFH) on visual outcome after macula-off retinal detachment repair. The results showed that preoperative SFFH was related to postoperative visual acuity, but not associated with age, preoperative visual acuity, duration of symptoms, or use of perfluorocarbon liquids.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Neurosciences
Niccolo Castellino, Antonio Longo, Matteo Fallico, Andrea Russo, Vincenza Bonfiglio, Gilda Cennamo, Federica Fossataro, Gabriella Fabbrocini, Anna Balato, Guglielmo Parisi, Rosa Maria D'urso, Francesco Lacarrubba, Maria Letizia Musumeci, Pietro Alosi, Francesco Petrillo, Giuseppe Micali, Teresio Avitabile, Michele Reibaldi
Summary: This study investigated the vascular status of the macula in psoriasis patients using OCTA, finding lower vascular density in both superficial and deep capillary plexuses in the psoriasis group compared to controls. The results suggest that vascular changes may occur earlier than clinical onset of posterior inflammation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Ophthalmology
Aditya Bansal, Wei Wei Lee, Tina Felfeli, Rajeev H. Muni
Summary: This study characterized the in vivo physiology of retinal reattachment in humans using high resolution SS-OCT that occurs in 5 specific stages. Delayed progression through certain stages was characterized by postoperative anatomic abnormalities.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Valerie Mane, Ismael Chehaibou, Mathieu Lehmann, Elise Philippakis, Pierre-Raphael Rothschild, Elodie Bousquet, Ramin Tadayoni
Summary: The study aimed to assess preoperative OCT findings of foveal-splitting retinal detachment patients and determine postoperative outcomes. It was found that patients with foveal-splitting RD had better preoperative visual acuity compared to macula-Off eyes and similar postoperative visual acuity to macula-On eyes after 1 year.
Article
Medicine, General & Internal
Lars H. B. Mackenbrock, Isabella D. Baur, Grzegorz Labuz, Gerd U. Auffarth, Ramin Khoramnia
Summary: Cataract surgery can lead to inflammatory processes in the retina, resulting in prolonged recovery times and reduced functional outcomes. This study investigates the impact of phacoemulsification parameters on macular thickness after surgery. The results showed a significant increase in retinal thickness and volume after cataract surgery, with correlations found between ultrasound energy, cataract density, and changes in macular thickness.
Review
Biotechnology & Applied Microbiology
Chuanzhen Zheng, Dejia Wen, Kejia Xu, Xiaomin Zhang, Xinjun Ren, Xiaorong Li
Summary: Rhegmatogenous retinal detachment (RRD) is a common emergency condition that can cause blindness without surgical treatment. The current main treatment option is pars plana vitrectomy, but the postoperative face-down position and unsatisfactory first retinal reattachment rate pose a burden on patients. However, researchers have developed biomaterials that can be used as retinal patches, replacing long-lasting vitreous substitutes and eliminating the postoperative face-down position.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Lijie Zhang, Rongyao Dong, Robert J. Zawadzki, Pengfei Zhang
Summary: Optoretinogram, utilizing OCT to measure retinal functions, is a potentially useful tool for quantifying retinal health alterations. This study improved accuracy by collecting volumetric data and developing a 3D registration approach, revealing novel functional signals and enabling monitoring of local and global functional changes in rodent eyes.
JOURNAL OF BIOPHOTONICS
(2022)
Review
Optics
Danuta M. Sampson, Adam M. Dubis, Fred K. Chen, Robert J. Zawadzki, David D. Sampson
Summary: The visualization and assessment of retinal microvasculature are crucial in the study and treatment of eye and systemic diseases. However, the current methods and analysis of OCTA imaging lack consistency, hindering progress. This paper proposes steps to standardize OCTA imaging, including imaging protocols, data analysis methods, metrics, reporting, and clinical practice, to address these limitations.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Medicine, Research & Experimental
Sook Hyun Chung, Tzu-Ni Sin, Brian Dang, Taylor Ngo, Therlinder Lo, Daniella Lent-Schochet, Ratheesh K. Meleppat, Robert J. Zawadzki, Glenn Yiu
Summary: This study compares the effectiveness of using single versus paired gRNAs in the CRISPR-Cas9 system to target the Vegfa gene. Paired gRNAs increased gene ablation rates in human cells but did not enhance VEGF suppression in mouse eyes. Using two gRNAs for genome editing may increase the risk of off-target effects.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Ophthalmology
Ratheesh K. Meleppat, Christopher R. Fortenbach, Yifan Jian, Esteban Soto Martinez, Karen Wagner, Bobeck S. Modjtahedi, Monica J. Motta, Deepa L. Ramamurthy, Ivan R. Schwab, Robert J. Zawadzki
Summary: In vivo evaluation of the structural morphology and vascular plexuses of the neurosensory retina and choroid across vertebrate species was performed using SS-OCT and SS-OCTA imaging. The results showed that the retinal morphology and vascular plexuses varied among different species. These methods can be used to evaluate retinal diseases in various species.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Optics
Kari V. Vienola, Denise Valente, Robert J. Zawadzki, Ravi S. Jonnal
Summary: Optoretinography (ORG) is a noninvasive and objective tool for testing neural function in the retina. It has the potential to transform ophthalmic care and clinical trials of therapeutics for visual function. The article presents an alternative approach that monitors the velocity of retinal features instead of tracking their positions, reducing the complexity and cost of position-based methods.
Article
Optics
Soohyun Lee, Stacey S. Choi, Ratheesh K. Meleppat, Robert J. Zawadzki, Nathan Doble
Summary: This article describes a high-speed, adaptive optics partially confocal multi-spot ophthalmoscope (AO-pcMSO) that utilizes a digital micromirror device (DMD) in the illumination channel and a fast 2D CMOS camera. The camera is synchronized with the DMD to project multiple AO-corrected spots onto the human retina simultaneously. Spatial filtering on each raw retinal image acts as an array virtual pinholes. The parallel projection scheme achieves a frame acquisition rate of 250 fps and improves contrast by 2-3 fold compared to a standard flood illumination architecture. Partially confocal images of the human retina reveal cone and rod photoreceptors at various retinal eccentricities.
Article
Biochemical Research Methods
Pengfei Zhang, Daniel J. Wahl, Jacopo Mocci, Eric B. Miller, Stefano Bonora, Marinko Sarunic, Robert J. Zawadzki
Summary: Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), invented in the 1980s, have greatly advanced in vivo retinal diagnostics in ophthalmology clinics and vision science research. Adaptive optics (AO) technology improves the resolution and sensitivity of SLO and OCT systems by correcting ocular aberrations. Integrating OCT into an existing mouse retinal AO-SLO system allows for multi-modal AO-enhanced imaging of the living mouse eye with high acquisition speed and resolution.
BIOMEDICAL OPTICS EXPRESS
(2023)
Proceedings Paper
Instruments & Instrumentation
Hang Chan Jo, Robert J. Zawadzki, Dae Yu Kim
Summary: Adaptive optics (AO) is a technique that compensates for aberration in optical imaging systems. Previous research has focused on improving AO performance through the use of spherical mirrors and off-axis designs.
OPTICAL SYSTEM ALIGNMENT, TOLERANCING, AND VERIFICATION XIV
(2022)
Meeting Abstract
Ophthalmology
Robert J. Zawadzki, Ratheesh K. Meleppat, Denise Valente, Soohyun Lee, Kari V. Vienola, Pengfei Zhang, Ravi S. Jonnal, Nathan Doble
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Kari V. Vienola, Robert J. Zawadzki, Ravi S. Jonnal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Subeen Park, Hang Chan Jo, Kyoung Min Lee, Da Young Song, Robert J. Zawadzki, Dae Yu Kim, Seok Hwan Kim, Jae Hun Kim
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Ewelina Pijewska, Kari V. Vienola, Michal Meina, Pengfei Zhang, Ratheesh K. Meleppat, Maciej Szkulmowski, Ravi S. Jonnal, Robert J. Zawadzki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Christopher Loh, Pengfei Zhang, Ratheesh K. Meleppat, Oscar Ramos-Soto, Sandra E. Balderas-Mata, Robert J. Zawadzki, Susanna S. Park
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Ratheesh K. Meleppat, Kaitryn Ronning, Sarah J. Karlen, J. KarlenMarie E. Burns, Robert J. Zawadzki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Jessicca Cho, Pengfei Zhang, Sarah J. Karlen, Nicholas Marsh-Armstrong, Anna La Torre, Robert J. Zawadzki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)