Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Yingrui Yang, Hongmei Zhang, Mengting Xia, Ranran Huang, Yuming Wang, Zhijie Li
Summary: The study found that different age, region, disease duration, and DR severity could affect the prevalence and association rules of eye diseases in diabetic patients. Patients in rural areas and older age groups are more likely to develop eye diseases, and those with multiple eye diseases concurrently have a higher risk.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Shih-Hsiang Ou, Wei-Che Chang, Ling-Ying Wu, Shiow-Ing Wang, James Cheng-Chung Wei, Po-Tsang Lee
Summary: This study aimed to evaluate whether the presence of DME can predict renal failure in patients with diabetes. Retrospective cohort study found that patients in the DME group had worse medication usage, renal function, and blood sugar control than those in the non-DME group. After matching, the DME group had a significantly higher risk of ESRD, dialysis, and renal transplantation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Huiling Tan, Xin Wang, Kaiyou Ye, Jianmin Lin, E. Song, Lihua Gong
Summary: This study investigated the prevalence and risk factors of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus (T2DM) in Qingpu, Shanghai. The prevalence of DR was 10.1%, with non-proliferative DR being more common. Higher fasting plasma glucose and glycated hemoglobinA1c were identified as known risk factors for DR, while no association was found between lipid indicators and DR. Additionally, higher levels of urea nitrogen and urinary albumin were associated with an increased risk of DR.
Article
Ophthalmology
Ahmed Abdelshafy Tabl, Tarek Tawfik Soliman, Mohamed Anany Elsayed, Marwa Abdelshafy Tabl
Summary: This study compared the efficacy and safety of suprachoroidal and intravitreal injection of triamcinolone acetonide for pseudophakic patients with refractory diabetic macular edema. The results showed that both treatments were effective in reducing central foveal thickness and improving visual acuity, but intravitreal injection had a higher recurrence rate and elevated intraocular pressure.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Andrew Mihalache, Amin Hatamnejad, Nikhil S. Patil, Marko M. Popovic, Peter J. Kertes, Miguel Cruz-Pimentel, Rajeev H. Muni
Summary: In patients with macular edema secondary to retinal vein occlusion, high dose intravitreal triamcinolone acetonide (IVTA) showed better improvements in visual acuity and reduction in retinal thickness compared to low dose IVTA. However, high dose IVTA had a higher risk of intraocular pressure-related adverse events and cataract surgery. These differences were not observed in patients with diabetic macular edema.
Article
Medicine, General & Internal
Fusae Kato, Miho Nozaki, Aki Kato, Tsutomu Yasukawa
Summary: This study used OCTA to investigate microvascular changes after intravitreal TA treatment. The results showed that TA can decrease the number of microaneurysms and increase the foveal avascular zone area.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Farhad Fazel, Mohammad Malekahmadi, Awat Feizi, Behrooz Oliya, Mehdi Tavakoli, Mohammadreza Fazel
Summary: This study investigated the efficacy of combining suprachoroidal triamcinolone acetonide (SCTA) with intravitreal bevacizumab (IVB) in patients with center-involving diabetic macular edema (CI-DME). The results showed that the combination of SCTA and IVB had significant improvements in both visual acuity and retinal thickness, with no significant side effects observed.
Article
Ophthalmology
Rei Sotani-Ogawa, Sentaro Kusuhara, Yushi Hirota, Kyung Woo Kim, Wataru Matsumiya, Wataru Ogawa, Makoto Nakamura
Summary: This pilot study aimed to evaluate the effects of STTA on glycemic control in patients with DME. The results showed that although there were no significant changes in CGM metrics, four patients developed hyperglycemia after STTA treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Article
Ophthalmology
Dilsher S. Dhoot, Hadi Moini, Kimberly Reed, Weiming Du, Robert Vitti, Alyson J. Berliner, Rishi P. Singh
Summary: This study aimed to assess the time to, cumulative incidence of, and functional benefit of achieving sustained improvement in diabetic macular oedema (DMO) in terms of the Diabetic Retinopathy Severity Scale (DRSS). The results showed that patients treated with intravitreal aflibercept injections achieved sustained improvement in DRSS earlier and more frequently compared to laser treatment, and this improvement was associated with greater improvement in visual acuity, independent of central subfield thickness reduction.
Article
Ophthalmology
Mahmoud Mohammed Ahmed Ali Khalil, Hosam Othman Mansour, Ahmed Mohamed Raafat Tawfik, Ahmed Gomaa Elmahdy
Summary: The study indicated that combining cataract surgery with drug injections can effectively prevent further progression in CMT for patients with diabetic macular edema following cataract surgery.
Review
Biochemistry & Molecular Biology
Cameron D. Haydinger, Genevieve F. Oliver, Liam M. Ashander, Justine R. Smith
Summary: Diabetic retinopathy is a retinal disease associated with hyperglycemia in diabetes patients, affecting both the central and peripheral retina. Its major mechanism involves oxidative stress caused by elevated production of reactive oxygen species, which is particularly harmful to the retina due to its high metabolic activity. This review provides an overview of the role of oxidative stress in diabetic retinopathy, including the formation and effects of advanced glycation end-products, metabolic memory, and non-coding RNA, as well as potential therapeutic strategies.
Article
Medicine, General & Internal
Nenad Petrovic, Dusan Todorovic, Tatjana Sarenac Vulovic, Suncica Sreckovic, Fatima Zivic, Dijana Risimic
Summary: The study aimed to examine whether additional intravitreal application of triamcinolone acetonide could improve therapeutic outcomes for pseudophakic eyes with persistent diabetic macular edema. Results showed that combined therapy led to a better anatomical outcome, but did not significantly improve visual acuity compared to continuous anti-VEGF therapy alone.
MEDICINA-LITHUANIA
(2023)
Article
Ophthalmology
Ryo Mukai, Hidetaka Matsumoto, Hideo Akiyama
Summary: The study explores the clinical outcomes of vitrectomy for intractable DME where anti-VEGF agents or periocular steroids have proven ineffective. Results suggest that vitrectomy may help stabilize retinal morphology in such cases, especially when accompanied by ERM or VMT.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Cell Biology
Ning Zhang, Jing Ke, Dawei Zhang, Yuanyuan Zhang, Ying Fu, Bin Cao, Dong Zhao
Summary: Plasma cytokines were found to be closely associated with diabetic macular edema (DME) and a dynamic nomogram for predicting DME, including novel growth factors and receptors, was developed. The nomogram demonstrated good calibration and discrimination in predicting DME, showing promising results for identifying and predicting DME.
