Article
Chemistry, Multidisciplinary
Qi-Long Hu, Jia-Tian Liu, Guangjin Fan, Jian Li, Yixian Li, Albert S. C. Chan, Xiao-Feng Xiong
Summary: This article reports a method of on-resin peptide modification that combines the efficiency of solid-phase peptide synthesis and avoids tedious purification procedures. The transition-metal-free and redox-neutral approach for solid-phase Met diversification with substrate diversity is described, which can be used to synthesize cyclic peptides of different sizes.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Medicinal
Shimei Xiao, Zhiqiang Wang, Huanli Zhang, Lei Zhao, Qingran Chang, Xiong Zhang, Rui Yan, Xiaodan Wu, Yingxue Jin
Summary: The methylation of amino acid residues plays a crucial role in the biological function of bioactive peptides. Methylation and stereostructural modifications of marine cyclic peptide galaxamide analogs were synthesized, and the effects of methylation on bioactivity were investigated. It was found that single-methyl substitution had a beneficial effect on the bioactivity of cyclic analogs with isoindolinone fragments, although the influence of methylation on bioactivity was uncertain and case-specific.
Article
Chemistry, Medicinal
Jinzheng Wang, Xuechen Li
Summary: Non-ribosomal cyclic peptides are abundant in natural sources and exhibit attractive bioactivities and favorable pharmacological properties. Their total synthesis can be achieved through peptide ligation, which offers advantages in cyclizing peptides. This strategy highlights the unique features of achieving total synthesis in cyclic peptide synthesis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Maria Leko, Polina Filippova, Marina Dorosh, Karin Rustler, Thomas Bruckdorfer, Sergey Burov
Summary: The study proposes the use of an EtOAc/AcN mixture as an efficient solvent alternative, successfully replacing DCM, THF, 2-MeTHF, and DMF in the synthesis and ensuring loading levels. This alternative option effectively achieves the synthesis of the target compound.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Chung-Yin Lin, Subrata Chakraborty, Chia-Wei Wong, Dar-Fu Tai
Summary: The study attempted to synthesize naturally occurring alpha-cyclic tripeptide cyclo(GPE), but ended up with the synthesis of alpha-cyclic hexapeptide cyclo(GPE(OBn))(2) which was then converted to cyclic hexapeptide cyclo(GPE)(2). Cyclization at higher temperature induced racemization.
Article
Chemistry, Medicinal
Huanli Zhang, Jingwan Wu, Jingchun Wang, Shimei Xiao, Lei Zhao, Rui Yan, Xiaodan Wu, Zhiqiang Wang, Li Fan, Yingxue Jin
Summary: This paper investigates the bioactivity of small cyclopeptides and the influence of structural changes on their bioactivity. It finds that incorporating specific fragments can enhance the bioactivity of cyclopeptides. In vitro studies show that cyclopeptides can induce apoptosis in tumor cells and cause cell cycle arrest.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Engineering, Biomedical
Yejiao Shi, David W. Wareham, Yichen Yuan, Xinru Deng, Alvaro Mata, Helena S. Azevedo
Summary: Repurposing old antibiotics, such as polymyxin B, into a peptide hydrogel for targeted and sustained release shows promise in treating multidrug-resistant bacterial infections. The hydrogel demonstrates prolonged antimicrobial activities against Gram-negative bacteria and can be further enhanced with the incorporation of additional antibiotics, making it a versatile platform for combined antimicrobial therapies.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ogonna Nwajiobi, Ashish Kumar Verma, Monika Raj
Summary: A novel rapid arene triazene strategy for macrocyclization of peptides is reported, which can generate a chromophoric triazene moiety at the site of cyclization within a minute. The resulting triazene cyclic peptide is highly stable but responsive to external stimuli and can undergo ring opening and re-cyclization. This method works with unprotected peptides and has been applied for the synthesis of monocycles and bicycles with various amino acid compositions. The stability of triazene cyclic peptides allows post-cyclization modification. This strategy has important applications in chemical biology, selective drug delivery, and identification of cyclic peptide hits.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Alla Troska, Meeli Arujoe, Anton Mastitski, Jaak Jarv, Anu Ploom
Summary: The steric hindrance of aza-amino acid plays a crucial role in controlling the rate and yield of aza-peptide bond formation, overshadowing the influence of activated amino acid and semicarbazide moiety. The reaction rates vary depending on the amino acid side chain bulkiness, with more sterically demanding amino acids showing no reaction under certain conditions.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Physical
Tongyao Wei, Dongfang Li, Yue Zhang, Yubo Tang, Haiyan Zhou, Han Liu, Xuechen Li
Summary: Ortho-phthalaldehyde has been found to have wide potentials for protein bioconjugation and peptide cyclization. This study reports a second-generation dialdehyde-based peptide cyclization method using thiophene-2,3-dialdehyde (TDA) that reacts specifically with primary amine and thiol within unprotected peptides, generating a highly stable cyclic structure.
Article
Biochemistry & Molecular Biology
Cristian Guarise, Davide Ceradini, Martina Tessari, Mauro Pavan, Stefano Moro, Veronica Salmaso, Carlo Barbera, Riccardo Beninatto, Devis Galesso
Summary: A new class of MMP3Is based on a small peptide backbone derivatized with an alkyl chain was developed, showing effective inhibitory activity and water solubility for potential treatment of osteoarthritis. The most effective MMPI, e(I), reversed inflammatory outcomes in vitro and promoted stable micellar formulation at higher concentrations in water, potentially increasing bioavailability and efficacy of the MMPIs.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Xinjian Ji, Alexander L. Nielsen, Christian Heinis
Summary: Cyclic peptides are a class of molecules widely found in nature and used in drug development. Advances in synthesis and drug development have led to the creation of many cyclic peptide drugs. Cyclic peptides possess favorable properties that make them attractive for drug development. Currently, there are over 40 cyclic peptide drugs in use, and new technological advances suggest that this number could rapidly increase.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Michael O. Frederick, Raymond A. Boyse, Timothy M. Braden, Joel R. Calvin, Bradley M. Campbell, Shujauddin M. Changi, Stephanie R. Coffin, Carmel Condon, Olivia Gowran, Jennifer McClary Groh, Stephen R. Groskreutz, Zachary D. Harms, Ashley A. Humenik, Neil J. Kallman, Nicholas D. Klitzing, Michael E. Kopach, Juliana K. Kretsinger, Gordon R. Lambertus, Jeffrey T. Lampert, Laura M. Maguire, Humphrey A. Moynihan, Nessa S. Mullane, John D. Murphy, Marie E. O'Mahony, Rachel N. Richey, Kevin D. Seibert, Richard D. Spencer, Mark A. Strege, Nil Tandogan, Frank L. Torres Torres, Sergey Tsukanov, Han Xia
Summary: The study successfully synthesized tirzepatide using a hybrid SPPS/LPPS method, achieving high yields and purity with continuous manufacturing and real-time monitoring. Intermediate purification through nanofiltration was implemented to avoid difficult precipitations in the process.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Review
Chemistry, Multidisciplinary
Hichem Moulahoum, Faezeh Ghorbanizamani, Kerem Tok, Figen Zihnioglu
Summary: Peptides are important biomolecules with various applications. However, they have limitations such as flexible conformations and susceptibility to degradation. The discovery of cyclic peptides in plants has provided new insights for overcoming these issues.
Article
Chemistry, Applied
John Lopez, Janina Beck, Christoph Bucher, Arne Berthelmann, Spyridon Markos, Stefan Eissler
Summary: In this study, an efficient procedure for loading the first amino acid onto the 2-CTC resin using the green solvent N-butylpyrrolidinone was disclosed. Key critical process parameters were identified using a design of experiment models.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Engineering, Electrical & Electronic
Mohammadrahim Kazemzadeh, Colin L. Hisey, Priscila Dauros-Singorenko, Simon Swift, Kamran Zargar-Shoshtari, Weiliang Xu, Neil G. R. Broderick
Summary: Bacterial extracellular vesicles (EVs) are nano-scale lipid-enclosed packages that play important roles in various biological processes. This study demonstrates the potential of using surface-enhanced Raman spectroscopy (SERS) and machine learning algorithms to rapidly classify and characterize bacterial EVs, which is crucial for the development of their laboratory and clinical applications.
IEEE SENSORS JOURNAL
(2022)
Article
Automation & Control Systems
Shahab Kazemi, Ryman Hashem, Martin Stommel, Leo K. Cheng, Weiliang Xu
Summary: This study implements closed-loop methods for controlling gastric simulators for the first time, demonstrating the superiority of closed-loop techniques over open-loop approaches through experimental results. By using the RiSPA bellows-driven soft pneumatic actuator as the main actuation system, all technical aspects of implementing closed-loop control and sensor-actuator integration are discussed in detail.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Chemistry, Multidisciplinary
Wei-Wei Shi, Chaowei Shi, Tong-Yue Wang, Yu-Lei Li, Yong-Kang Zhou, Xu-Han Zhang, Donald Bierer, Ji-Shen Zheng, Lei Liu
Summary: The chemical synthesis of correctly folded proteins with multiple or interchain disulfide bonds was expedited using a removable glycosylation modification (RGM) strategy, which introduces O-linked beta-N-acetylglucosamine (O-GlcNAc) groups to improve folding and can be efficiently removed afterwards.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Physical
Fa Yang, Weilin Xu
Summary: The development of cost-effective, high-performance catalysts at the atomic level is crucial for large-scale applications of renewable clean energy conversion. Single-atomic site catalysts (SACs) have great potential as next-generation materials, with the introduction and coupling of synergistic components to improve activity. Various atomic-coupling structures, including SAC-NPs, SACCs, DACs, and SAAs, offer unique synergistic effects that need further exploration and comparison.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Multidisciplinary Sciences
Xiaodong Liu, Xin Ge, Jing Cao, Yi Xiao, Yan Wang, Wei Zhang, Ping Song, Weilin Xu
Summary: This study investigated the catalysis of Pt SAC at the single-molecule single-atom level and found both static and dynamic activity heterogeneity. It was revealed that the intrinsic catalytic activity of Pt SAC is higher than that of Pt nanoparticles, and there is no catalysis-induced surface restructuring in Pt SAC. Density functional theory calculations further suggested that the unique catalytic properties of Pt SAC or the differences between Pt SAC and nanoparticles could be attributed to the strong adsorptions, large surface energy, and strong binding of Pt-1 species.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Physical
Bingbao Mei, Cong Liu, Fanfei Sun, Siyu Lu, Xianlong Du, Xiaopeng Li, Fei Song, Weilin Xu, Zheng Jiang
Summary: Potential-dependent selectivity changes are widely observed in electrocatalysis, but a detailed understanding of these changes at an atomic level is still lacking. In this study, we use a model atomically dispersed nickel catalyst to obtain a comprehensive view of potential-induced structure changes during the CO2 reduction reaction. Our findings show that the catalyst exhibits volcano-like selectivity changes that are dependent on the distance between the nickel atom and the carbon basal plane. Theoretical calculations suggest that local dynamic behaviors play a crucial role in regulating the distribution of the d band center of nickel.
Article
Chemistry, Multidisciplinary
Mohammadrahim Kazemzadeh, Miguel Martinez-Calderon, Song Y. Paek, MoiMoi Lowe, Claude Aguergaray, Weiliang Xu, Lawrence W. Chamley, Neil G. R. Broderick, Colin L. Hisey
Summary: Placental extracellular vesicles (EVs) play important roles in pregnancy, but they are also implicated in the progression of preeclampsia. A fabrication process called laser-induced nano-structuring of SERS-active thin films (LINST) was developed to produce substrates that allow the biochemical fingerprinting of EVs. The findings encourage the exploration of surface-enhanced Raman spectroscopy (SERS) of EVs as a promising method for preeclampsia liquid biopsies.
Article
Automation & Control Systems
Dipankar Bhattacharya, Ryman Hashem, Leo K. Cheng, Weiliang Xu
Summary: This study presents the design and implementation of a novel robotic soft esophagus (RoSEv2.0) for esophageal stent testing and food viscosity studies. The RoSEv2.0 is equipped with embedded time of flight (TOF) and pressure sensors for modeling and control. Model predictive control (MPC) using SINDYC models was implemented to autonomously govern peristalsis and air pressure. Successful generation of peristalsis waves and migration testing of stents were achieved.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2022)
Article
Automation & Control Systems
Yuan Guo, Qianqian Tong, Xianzhong Liu, Xuesong Bian, Zhihao Zhang, Yuru Zhang, Weiliang Xu, Dangxiao Wang
Summary: In this paper, a magnetically responsive soft tactile device (MRS-Tex) is proposed for rendering high-resolution surface textures. By using a 1 mm diameter soft actuator and a soft membrane bracket, the device is capable of generating sufficient depth pits and achieving high discrimination accuracy according to quantitative experiments and user studies.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2022)
Article
Automation & Control Systems
Zixiao Chen, Zhicong Deng, Jaspreet Singh Dhupia, Martin Stommel, Weiliang Xu
Summary: This article introduces a new control framework for a soft robotic table, which has been experimentally proven to effectively achieve trajectory tracking control.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Chemistry, Multidisciplinary
Baochang Zhang, Yupeng Zheng, Guochao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang, Ji-Shen Zheng, Lei Liu
Summary: This article presents a new method called Backbone-Installed Split Intein-Assisted Ligation (BISIAL) for the synthesis of membrane-associated D-proteins. The BISIAL method allows smooth ligation under strongly chaotropic conditions and the removal of ligation scars on the products, enabling the synthesis of challenging Dprotein targets.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Automation & Control Systems
Bangxiang Chen, Jaspreet S. Dhupia, Weiliang Xu
Summary: This article introduces a chewing robot based on an adjustable linkage mechanism, which can provide crushing and grinding capability on food and allows users to customize the movement of the molars. The article discusses the robot's movement and two different operation modes, and validates the effectiveness of the planning and control through experiments.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Chemistry, Organic
Ruichao Ding, Wei-Wei Shi, Ji-Shen Zheng
Summary: We have successfully synthesized a large quantity of d-SortaseA with high purity using a hydrazide ligation strategy. The d-Sortase exhibited full activity towards d-peptides and D/L hybrid proteins, and the ligation efficiency was not affected by the chirality of the C-terminus substrate. This study suggests that d-sortase ligation can be used as a modern ligation method for d-proteins and D/L hybrid proteins, expanding the toolbox for chemical protein synthesis in biotechnology.
Review
Automation & Control Systems
Mahmoud Zarebidoki, Jaspreet Singh Dhupia, Weiliang Xu
IEEE ROBOTICS & AUTOMATION MAGAZINE
(2022)
Article
Automation & Control Systems
Zixiao Chen, Zhicong Deng, Jaspreet Singh Dhupia, Martin Stommel, Weiliang Xu
Summary: This article presents the development of a control framework for a soft robotic table, modeling the system through experiments and simulations, and designing a closed-loop trajectory tracking system. Experimental results show the effectiveness of the proposed trajectory tracking control method.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
