Article
Biochemical Research Methods
Rohan P. J. Hughes, Scott A. Read, Michael J. Collins, Stephen J. Vincent
Summary: This study examined anterior corneal, internal ocular, and total ocular higher order aberrations (HOA's), and retinal image quality in a non-myopic, paediatric cohort. The study found that internal ocular HOA's were higher in magnitude but partially compensated, resulting in reduced levels of HOA's and excellent retinal image quality. Weak correlations were observed between HOA's and age, sex, refractive error, and axial length. These findings provide an improved understanding of the optics and retinal image quality of children's eyes.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Pablo Artal, Harilaos Ginis, Dimitrios Christaras, Eloy A. Villegas, Juan Tabernero, Pedro M. Prieto
Summary: Current intraocular lenses (IOLs) focus on replacing the cataractous crystalline lens, but their common biconvex design neglects off-axis performance, resulting in reduced optical quality in the periphery of the retina. To address this, a concave-convex inverted meniscus IOL with aspheric surfaces was designed using ray-tracing simulations. The new IOL showed superior image quality throughout the visual field compared to the standard thin biconvex lenses commonly used, making it a better substitute for the natural lens.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Neurosciences
Rohan P. J. Hughes, Scott A. Read, Michael J. Collins, Stephen J. Vincent
Summary: Higher order aberrations increase and retinal image quality decreases significantly during higher levels of accommodation in children, similar to adults.
Article
Ophthalmology
Rohan P. J. Hughes, Scott A. Read, Michael J. Collins, Stephen J. Vincent
Summary: This study investigates the changes in higher order aberrations and retinal image quality during accommodation in children with different refractive errors. The results show that near work has a greater impact on myopic children, while non-myopic children show greater changes in spherical aberration during accommodation.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
Len Zheleznyak
Summary: This study investigates the impact of refractive error on peripheral image quality. Peripheral blur orientation is determined by optical aberrations and retinal shape. Peripheral blur anisotropy can play a role in accommodation, emmetropisation, and myopia control interventions. The study finds that different refractive errors result in variations in through-focus optical anisotropy and image quality, with myopes exhibiting vertically elongated blur, while emmetropes and hyperopes exhibit horizontally elongated blur.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Multidisciplinary Sciences
Sohee Jeon, Ayoung Choi, Hyunggoo Kwon
Summary: The newly developed extended-depth-of-focus AcrySof((R)) Vivity (TM) intraocular lens (IOL) shows promise in minimizing dysphotopsia, but has limitations in uncorrected near visual acuity (UNVA). A study found that pupil size is significantly associated with UNVA, suggesting that eyes with smaller pupils may benefit from UNVA.
Article
Optics
Yuta Miyanishi, Erdem Sahin, Atanas Gotchev
Summary: The spatio-angular resolution of a light field display plays a crucial role in delivering spatial image quality and eliciting an accommodation response. Previous studies have used ray-tracing and schematic eye models, which are computationally complex and inaccurately represent the behavior of the human eye population. In this study, we propose an efficient wave-optics-based framework to model the human eye and a general light field display. The simulation results show that our framework can accurately characterize the retinal image quality and predict accommodation responses.
Article
Ophthalmology
Raman Prasad Sah, Matt Jaskulski, Pete S. Kollbaum
Summary: This study developed an optical model of a child's eye to investigate the impact of target distance and accommodative behavior on retinal image quality with multi-zone lenses. The results showed that adjusting spherical aberration and pupil radius resulted in wider defocus distributions at closer viewing distances. Additionally, accommodative lag had little effect on the legibility of typical text.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Ophthalmology
Chenglu Ding, Yunyun Chen, Xue Li, Yingying Huang, Hao Chen, Jinhua Bao
Summary: Increased higher-order aberrations and improved accommodative accuracy were observed during orthokeratology treatment, but began to regress after the cessation of orthokeratology. A significant positive correlation between improved accommodative accuracy and slowed axial elongation was only observed during the first 6 months of treatment.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Optics
Maria Mecho-Garcia, Inaki Blanco-Martinez, Paulo Fernandes, Rute J. Macedo-de-Araujo, Miguel Faria-Ribeiro, Jose Manuel Gonzalez-Meijome
Summary: This study aimed to investigate the effect of pupil dilation with Phenylephrine Hydrochloride (PHCl) on the accommodative response and Zernike coefficient magnitude. Results showed statistically significant differences in the Zernike coefficients C-3(-1), C-3(1), C-4(0), and C-6(0) between natural conditions and after pupil dilation with PHCl.
Letter
Ophthalmology
Ying Yan, Bo Zeng, Chengyuan Gao, Yanping Song, Xiao Chen
Summary: This article provides answers to the questions raised by Lei Gao et al. regarding the effects of refractive accommodation on subfoveal choroidal thickness in silicone oil-filled eyes.
Article
Optics
Yanbo Zhao, Fengzhou Fang
Summary: In this study, a dynamic opto-mechanical eye model with a wide visual field was developed to validate the aberrometer for peripheral aberration measurement. The model consists of a plano-convex lens representing cornea, a double-convex lens representing crystalline lens, and a spherical retinal screen. The model's adjustable retina allows for Zernike 4th item (Z4 focus) range adjustment and the model can mimic human eyes with different visual field and pupil sizes in peripheral aberration measurement.
Article
Mechanics
Qing Miao, Langquan Li, Xingcai Pi, Yue Qiu, Ming Fang
Summary: An effective gas-surface interaction model is essential for accurately predicting the aerodynamic thermal properties of hypersonic vehicles. Classical interface models are not applicable under hypersonic conditions due to significant variations in boundary properties predicted by different gas-surface interaction models, posing a serious threat to flight safety. This study analyzed the reflection behavior of gas on a silicon-based surface through molecular dynamics simulations and proposed a modified Maxwell model to accurately describe gas-surface interaction under hypersonic conditions. The results provide insights into the microscopic mechanism of gas-surface interaction and offer an important foundation for establishing accurate boundary conditions for larger-scale simulations.
Article
Ophthalmology
James S. Wolffsohn, Monica Jong, Earl L. Smith, Serge R. Resnikoff, Jost B. Jonas, Nicola S. Logan, Ian Morgan, Padmaja Sankaridurg, Kyoko Ohno-Matsui
Summary: The International Myopia Institute (IMI) is focused on advancing research, education, and management in the field of myopia to reduce the incidence of future vision impairment and blindness associated with increasing myopia. By promoting collaboration and knowledge sharing, IMI addresses issues such as pathologic myopia, the impact of myopia, risk factors, accommodation, binocular vision, and myopia prevention.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Pediatrics
Ana M. Calvo-Maroto, Sara Llorente-Gonzalez, Jaione Bezunartea-Bezunartea, Francisco Javier Hurtado-Cena, Clara Berrozpe-Villabona, Valentina Bilbao-Malave, David P. Pinero, Jesus Barrio-Barrio, Sergio Recalde-Maestre
Summary: The aim of this study was to compare refraction measurements with and without cycloplegia in children using two different devices. The study found that both devices provided accurate refractions without cycloplegia in myopia children, while they did not eliminate instrument myopia and accommodation related to hyperopia children.
Article
Optics
Maciej M. Bartuzel, D. Robert Iskander, Ivan Marin-Franch, Norberto Lopez-Gil
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2019)
Article
Optics
Larry N. Thibos, Arthur Bradley, Renfeng Xu, Norberto Lopez-Gil
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2019)
Article
Optics
Renfeng Xu, Larry N. Thibos, Norberto Lopez-Gil, Pete Kollbaum, Arthur Bradley
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2019)
Review
Ophthalmology
Antonio J. Del Aguila-Carrasco, Philip B. Kruger, Francisco Lara, Norberto Lopez-Gil
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2020)
Article
Ophthalmology
Rosa Maria Salmeron-Campillo, Mateusz Jaskulski, Sergio Lara-Canovas, Jose Manuel Gonzalez-Meijome, Norberto Lopez-Gil
JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Francisco Lara, Antonio J. Del Aguila-Carrasco, Ivan Marin-Franch, Resurreccion Riquelme-Nicolas, Norberto Lopez-Gil
OPTOMETRY AND VISION SCIENCE
(2020)
Article
Ophthalmology
Juan F. Zapata-Diaz, Miguel A. Rodriguez-Izquierdo, Nassima Ould-Amer, Jeronimo Lajara-Blesa, Norberto Lopez-Gil
JOURNAL OF REFRACTIVE SURGERY
(2020)
Article
Biochemical Research Methods
Andrew J. Bower, Tao Liu, Nancy Aguilera, Joanne Li, Jianfei Liu, Rongwen Lu, John P. Giannini, Laryssa A. Huryn, Alfredo Dubra, Zhuolin Liu, Daniel X. Hammer, Johnny Tam
Summary: The study developed an imaging platform combining multimodal AO-SLO with AO-OCT to compare four different modalities for imaging RPE cells in the same eye. Consistent cellular structure information was obtained across modalities, with variations in RPE cell contrast explored in a subject-, location-, and even cell-dependent manner. The benefit of using multiple modalities to infer the cellular structure of the RPE mosaic in an affected eye was illustrated through multimodal imaging in a patient with choroideremia.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Ophthalmology
Francisco Lara-Lacarcel, Ivan Marin-Franch, Vicente Fernandez-Sanchez, Resurreccion Riquelme-Nicolas, Norberto Lopez-Gil
Summary: The study found that there are small changes in both the power and axis of astigmatism during accommodation, especially when convergence is involved. These changes in astigmatism may be attributed to shifts in the position of the crystalline lens during accommodation.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Computer Science, Interdisciplinary Applications
Jianfei Liu, Christine Shen, Nancy Aguilera, Catherine Cukras, Robert B. Hufnagel, Wadih M. Zein, Tao Liu, Johnny Tam
Summary: This paper introduces a method called A-GANs, which efficiently generates annotated images by combining ACAM and C-GANs. Experimental results show that it performs well in cell segmentation and synthesizing realistic images.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Letter
Ophthalmology
Joanne Li, Nancy Aguilera, Tao Liu, Andrew J. Bower, John P. Giannini, Catherine Cukras, Tiarnan D. L. Keenan, Emily Chew, Brian P. Brooks, Wadih M. Zein, Laryssa A. Huryn, Robert B. Hufnagel, Johnny Tam
Article
Biology
Nancy Aguilera, Tao Liu, Andrew J. Bower, Joanne Li, Sarah Abouassali, Rongwen Lu, John Giannini, Maximilian Pfau, Chelsea Bender, Margery G. Smelkinson, Amelia Naik, Bin Guan, Owen Schwartz, Andrei Volkov, Alfredo Dubra, Zhuolin Liu, Daniel X. Hammer, Dragan Maric, Robert Fariss, Robert B. Hufnagel, Brett G. Jeffrey, Brian P. Brooks, Wadih M. Zein, Laryssa A. Huryn, Johnny Tam
Summary: In this study, multimodal adaptive optics imaging was used to visualize the pathogenesis of choroideremia in living human eyes. The presence of subclinical enlarged retinal pigment epithelial (RPE) cells in all subjects imaged was demonstrated. The RPE disruption was found to be greater in the fovea, the last area to be affected in choroideremia, than in the photoreceptor or choriocapillaris layers. Unexpectedly, patches of fluoroscently-labeled but structurally and functionally normal photoreceptors were found, suggesting altered RPE blood barrier function in choroideremia. A strategy for detecting enlarged cells using conventional ophthalmic imaging instrumentation was also introduced. These findings establish the presence of subclinical polymegathism of RPE cells in choroideremia and provide evidence for the pathogenesis of this blinding retinal degeneration.
COMMUNICATIONS BIOLOGY
(2022)
Article
Computer Science, Information Systems
Jianfei Liu, Yoo-Jean Han, Tao Liu, Nancy Aguilera, Johnny Tam
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2020)
Article
Ophthalmology
Juan F. Zapata-Diaz, Hema Radhakrishnan, W. Neil Charman, Norberto Lopez-Gil
JOURNAL OF OPTOMETRY
(2019)
Article
Ophthalmology
Antonio J. Del Aguila-Carrasco, Francisco Lara, Paula Bernal-Molina, Resurreccion Riquelme-Nicolas, Ivan Marin-Franch, Jose J. Esteve-Taboada, Robert Montes-Mico, Philip B. Kruger, Norberto Lopez-Gil
JOURNAL OF OPTOMETRY
(2019)