Journal
TETRAHEDRON LETTERS
Volume 56, Issue 30, Pages 4509-4511Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.05.117
Keywords
Bisnortriterpenoid; Biological activity; Synthesis; Vinylogous Mukaiyama aldol; Stereocontrol
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Funding
- National Natural Science Foundation of China [21172096, 21472075]
- Fundamental Research Funds for the Central Universities [lzu-jbky-2014-59]
- '111' Project of MoE
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The first synthesis of 6,5,5,5-tetracyclic moiety related with promising anti-HIV activity in rubriflordilactone B has been efficiently achieved. Our strategy started from cheap materials, and features the utilization of radical 1,5-H abstraction/cyclization and vinylogous Mukaiyama aldol reaction, which successfully established the array of five continuous stereogenic carbon centers in the target. (C) 2015 Elsevier Ltd. All rights reserved.
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