Article
Veterinary Sciences
Nina Milevoj, Ana Nemec, Natasa Tozon
Summary: This study evaluated the efficacy of metronomic chemotherapy in the palliative treatment of malignant oral tumors in dogs. The results suggest that metronomic chemotherapy with cyclophosphamide can be beneficial in a subset of dogs, but disease progression was observed in most cases over time.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Giorgio Attina, Alberto Romano, Palma Maurizi, Sara D'Amuri, Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Antonio Ruggiero
Summary: Oral mucositis is a common complication of chemotherapy for childhood malignancies. The WHO oral mucositis scale is a valuable tool for assessing its severity in pediatric patients. In addition, WBS can be used as an assessment tool to determine the therapy for patients where direct evaluation of the oral cavity is not possible.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Claire O. Kisamore, Brittany D. Elliott, A. Courtney Devries, Randy J. Nelson, William H. Walker II
Summary: Circadian rhythms are internal manifestations of the 24-h solar day that synchronize biological and behavioral processes to improve adaptive function and survival. Chronotherapy optimizes drug administration based on circadian rhythms to achieve maximum therapeutic efficacy and minimize side effects. This review examines the evidence for chronotherapeutic treatment for solid tumors, including chrono-chemotherapy, chrono-radiotherapy, and alternative chronotherapeutics, and discusses areas for further research and challenges in the field.
Article
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: Mechanical features of cancer cells play a crucial role in tumor development and progression, with mechanosensory proteins potentially mediating oncogenic signaling and response to chemotherapy. Studying changes in tumor microenvironment and matrix rigidity can offer new anti-cancer strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Medicine, General & Internal
Luying Ryan Li, Bhuwan Chaudhary, Chao You, Jane A. Dennis, Helen Wakeford
Summary: The combination therapy of glucocorticoid with cyclophosphamide may slightly reduce mortality in hospitalized patients with oral paraquat poisoning, but its effect on mortality at three months post discharge remains uncertain. There is limited evidence on whether this treatment increases the risk of infection, highlighting the need for further research.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Cell Biology
Fatih M. Uckun, Taracad Venkatachalam
Summary: Repurposing FDA-approved BTK inhibitors as therapeutic agents for solid tumors could provide renewed hope for chemotherapy-resistant cancer patients. Emerging evidence suggests that BTK inhibitors have clinical potential in solid tumor therapy and may lead to the development of new and effective combination regimens for metastatic and/or therapy-refractory solid tumor patients through lead optimization and translational research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Casie S. Kubota, Peter J. Espenshade
Summary: This review summarizes the role of stearoyl-CoA desaturase (SCD) in cancer progression and proposes novel therapeutic strategies for targeting SCD in solid tumors.
Article
Nanoscience & Nanotechnology
Yuzhu Wang, Lu Jia, Tingting Hu, Zhuoran Yang, Chunyu Yang, Huiming Lin, Feng Zhang, Kai Yu, Fengyu Qu, Wei Guo
Summary: Although phototherapy has been extensively studied in recent years, its efficacy in treating tumors is often unsatisfactory due to the complex and variable tumor microenvironment. In this study, we report the discovery of novel hollow carriers named CoSn(OH)6@CoOOH with oxidase properties, which can enhance the effectiveness of phototherapy. These carriers react with oxygen to generate singlet oxygen and consume glutathione, and their hollow structure allows for the delivery of drug molecules. Loading indocyanine green and AIPH onto the carriers resulted in enhanced phototherapy effects through oxidase-catalyzed reactions, generation of alkyl radicals, and glutathione consumption. Cell and mouse experiments demonstrated that these carriers, combined with near-infrared laser irradiation, significantly inhibited tumor growth. Enrichment analysis revealed the involvement of the PI3K-Akt and MAPK signaling pathways in this therapeutic system. Hollow carriers with oxidase activity like these have great potential for the design of multifunctional drug delivery vehicles for tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Immunology
Seung-Jin Kim, Dipendra Khadka, Jae Ho Seo
Summary: This article discusses the process of tumors adapting to adverse environments through communication with neighboring cells. Understanding the physiology of these tumors and their interaction with the tumor environment can help in developing promising tumor treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andres Gramajo Lopez, Florencia Gutierrez, Lucila Saavedra, Elvira Maria Hebert, Susana Alvarez, Susana Salva
Summary: The study explores the effects of oral administration of viable and non-viable probiotics on reducing myelosuppression and immunosuppression induced by chemotherapy. Viable and non-viable Lr05 and Lp06 treatments were effective in promoting early recovery of bone marrow architecture and myeloid cells in mice treated with cyclophosphamide, with non-viable Lr05 showing potential as a resource for reducing chemotherapy-induced leukopenia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Daniel J. Olson, Kunle Odunsi
Summary: The long-term benefits of immunotherapy have not extended to most nonhematologic solid tumors. Adoptive cell therapy has shown promising results in immunogenic tumors and has the potential to improve immune response in traditionally nonresponsive tumors. Challenges include manufacturing logistics, accurate antigen identification, and off-tumor toxicity risk. Continued advancements in cancer immunology and cell engineering may help extend the benefits of immunotherapy to more patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Neta Bar-Hai, Dana Ishay-Ronen
Summary: Cancer is a complex and heterogeneous disease, and cell plasticity plays a crucial role in the formation and treatment of solid tumors. This plasticity leads to tumor heterogeneity, posing a challenge to cancer treatment. This review explores cell plasticity and treatment modalities, as well as the potential of utilizing enhanced plasticity for differentiation therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Maria de Miguel, Pablo Umana, Ana Luiza Gomes de Morais, Victor Moreno, Emiliano Calvo
Summary: T-cell engagers (TCE) are a novel group of treatments that simultaneously engage T-cell surface molecules and tumoral cell antigens. Success has been observed in hematologic field but not yet in solid tumors due to their biological complexity. Research is ongoing to improve solid tumors therapeutics through different strategies.
CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yi-Chao Zheng, Hui-Qin Kang, Bo Wang, Yuan-Zai Zhu, M. A. A. Mamun, Long-Fei Zhao, Hai-Qian Nie, Ying Liu, Li-Juan Zhao, Xiao-Nan Zhang, Mei-Mei Gao, Dan-Dan Jiang, Hong-Min Liu, Ya Gao
Summary: Histone deacetylase 6 (HDAC6) is highly expressed in various solid tumors and plays a crucial role in tumor cell proliferation, invasion, metastasis, drug resistance, stemness, and immunogenicity. HDAC6-specific inhibitors have shown promising results in preclinical and clinical trials, effectively killing tumor cells and enhancing patients' immunity during solid tumor therapy. This review provides an overview of HDAC6's structure, biological functions, mechanisms, and the development of selective inhibitors for solid tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Guanghao Li, Zuyu Yang, Dafei Wu, Sixue Liu, Xuening Li, Tao Li, Yawei Li, Liji Liang, Weilong Zou, Chung- Wu, Hurng-Yi Wang, Xuemei Lu
Summary: Spatial genetic and phenotypic diversity within solid tumors can have a significant impact on tumor development. The proposed neutral spatial model suggests that mutation accumulation increases towards the periphery and the genealogical relationships are spatially determined, influencing selection efficacy. Testing this model can provide insights into natural selection during tumorigenesis, particularly for small solid tumors.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)