Article
Cell Biology
Shiqing Liu, Chengping Hu, Min Li, Jian An, Wolong Zhou, Jia Guo, Yao Xiao
Summary: This study reveals that estrogen receptor beta promotes non-small-cell lung cancer cell invasion through regulating the circ-TMX4/miR-622/CXCR4 signaling pathway. These findings provide a new target for the development of treatment strategies to suppress lung cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Tai-Huang Lee, Gaun-You Lin, Ming-Hui Yang, Yu-Chang Tyan, Che-Hsin Lee
Summary: Salmonella suppresses CXCR4 protein expression and tumor cell migration ability by downregulating the Akt/mTOR signaling pathway, reducing tumor chemotactic response to CXCL12. In vivo experiments confirmed the anti-metastatic effect of Salmonella observed in vitro studies.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Isabel Hamshaw, Marco M. D. Cominetti, Wing-Yee Lai, Mark Searcey, Anja Mueller
Summary: Cancer metastasis is a major cause of cancer-related death. The CXCR4 receptor and its ligand CXCL12 play important roles in promoting metastasis, making them attractive therapeutic targets. In this study, a novel CXCR4 antagonist was developed and used for CXCR4-based imaging. The results showed that these antagonists were non-toxic and effectively inhibited cancer cell migration and calcium release.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Yunfeng Jin, Saiyan Bian, Hui Wang, Jiahang Mo, He Fei, Li Li, Tong Chen, Hua Jiang
Summary: Cancer associated fibroblasts (CAFs) play a crucial role in the progression of ovarian cancer (OvCA). The conditioned medium of primary CAFs can promote proliferation, migration, and invasion of ovarian cancer cells. It was found that the microtubule-associated protein CRMP2, derived from CAFs, is a key regulator responsible for mediating these cell events of OvCA.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Ruozheng Wei, Yuning Zhou, Chang Li, Piotr Rychahou, Shulin Zhang, William B. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Heidi L. Weiss, B. Mark Evers, Qingding Wang
Summary: This study identifies ketogenesis as a critical regulator of the tumor microenvironment in colorectal cancer and suggests the potential for ketogenic diets as a metabolic strategy to overcome immunosuppression and prolong survival.
Article
Multidisciplinary Sciences
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein
Summary: The study found that Wnt5A can regulate the expression of its receptors, affecting cell proliferation, migration, invasion, and multicellular aggregates formation. Moreover, Wnt5A can also modulate integrin expression levels, potentially associated with ovarian cancer cell proliferation, migration, and fibronectin attachment.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Sebastian Dekkers, Birgit Caspar, Joelle Goulding, Nicholas D. Kindon, Laura E. Kilpatrick, Leigh A. Stoddart, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill, Michael J. Stocks
Summary: In this study, fluorescent probes based on previously reported small-molecule antagonists were designed and synthesized using classic medicinal chemistry approaches to investigate the pharmacology and cellular distribution of the CXCR4 receptor. Three distinct chemical classes of fluorescent probes were developed and shown to specifically bind to the CXCR4 receptor in a fluorescence-based NanoBRET binding assay (pKD ranging 6.6-7.1). These probes were also used in competition binding experiments and confocal microscopy to further explore the pharmacology and cellular distribution of CXCR4.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Soontorn Tuntithavornwat, Daniel J. Shea, Bin Sheng Wong, Talia Guardia, Se Jong Lee, Christopher L. Yankaskas, Lei Zheng, Aikaterini Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos
Summary: Obscurins, encoded by the OBSCN gene, play a critical role in pancreatic cancer progression and metastasis by regulating cytoskeletal remodeling through RhoA activity. Decreased levels of giant obscurins in pancreatic ductal adenocarcinomas lead to faster cell migration, tumor growth, and metastasis development.
Article
Biochemistry & Molecular Biology
Zhijian Chen, Qing Xiao, Yang Shen, Chengjun Xue
Summary: In this study, the researchers discovered a novel transcriptional activator, FOXA2, for CXCR4 in esophageal cancer. They found that FOXA2 directly bound to the promoter region of CXCR4 and activated its expression in esophageal cancer cells. The upregulation of FOXA2 was correlated with the upregulation of CXCR4. Knockout of FOXA2 significantly inhibited esophageal cancer migration and metastasis, which could be rescued by ectopically expressed CXCR4. These findings provide new insights into the treatment of esophageal cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Agoston G. Nagy, Inna Szekacs, Attila Bonyar, Robert Horvath
Summary: This study successfully observed and quantified the invasiveness of cancer cells using digital holographic microscopy. The invasion speed of cancer cells was found to have a linear relationship with cell migration capability.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Tripti Khare, Marc Bissonnette, Sharad Khare
Summary: Chemokines like CXCL12 play a significant role in cancer growth and metastasis, with receptors like CXCR4 and CXCR7 being potential targets for treatment strategies in colorectal cancer. Targeting the CXCL12-CXCR4/CXCR7 axis shows promise in developing new therapies for CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wen Yin, Su-Min Qian
Summary: The study successfully synthesized a CD44v6-O-MWNTS/Gemcitabine/DOTAP system for the targeted therapy of ovarian cancer, which effectively loaded siRNA and anti-tumor drugs, inhibited cellular viability, induced cell apoptosis, and repressed tumor growth in vitro and in vivo. The system showed promising potential for the co-delivery of siRNA and anti-tumor drugs for the therapy of ovarian cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Abraham Akonnor, Masaki Makise, Akihiko Kuniyasu
Summary: A CXCR4-targeted antitumor peptidomimetic (CTCE-KLAK) was developed and showed cell-selective cytotoxicity against breast cancer cells and induced rapid necrotic cell death. In a mouse model, CTCE-KLAK significantly inhibited tumor growth and lung metastasis, highlighting its potential as a promising agent for treating triple-negative breast cancer.
Article
Immunology
Jorma Paavonen, Renee Turzanski Fortner, Matti Lehtinen, Annika Idahl
Summary: The link between Chlamydia trachomatis, pelvic inflammatory disease (PID), and epithelial ovarian cancer (EOC) may be relatively weak, but biologically plausible, requiring further investigation in future studies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
