Journal
ONCOLOGY RESEARCH
Volume 18, Issue 11-12, Pages 519-527Publisher
COGNIZANT COMMUNICATION CORP
DOI: 10.3727/096504010X12704916124909
Keywords
Cervical cancer; Human papillomavirus (HPV); Cidofovir (CDV); Proliferating cell nuclear antigen (PCNA); Apoptosis
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Cidofovir (CDV) is an acyclic nucleoside phosphonate analog that shows broad spectrum anti-DNA virus activity. In this study, we have investigated the influence of cidofovir on the tumor xenografts derived from He La and Si Ha cells on nude mice. The HeLa/SiHa xenografts in nude mice were established by inoculating cells subcutaneously. Administration of cidofovir by intratumoral injection led to significant tumor reduction. Enhanced protein levels of p53 and p-pRb within the tumor samples were observed. Immunohistology analysis of the tumor sections indicated decreased PCNA index and increased apoptosis index. Our study gives more evidence and explanation on in vivo inhibition effect of cidofovir on HPV genome-positive cervical carcinoma cell line xenografts.
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