Article
Cell Biology
Weilin Sun, Gang Ma, Li Zhang, Pengliang Wang, Nannan Zhang, Zizhen Wu, Yinping Dong, Fenglin Cai, Liqiao Chen, Huifang Liu, Han Liang, Jingyu Deng
Summary: ADAMTS9 in gastric cancer cells exerts inhibitory effects, with its decreased expression associated with malignant phenotypes and poor prognosis. Restoration of ADAMTS9 significantly suppressed the viability and motility of GC cells.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Canan Guvenc, Fien Neckebroeck, Asier Antoranz, Marjan Garmyn, Joost van den Oord, Francesca Maria Bosisio
Summary: Loss-of-function events in tumor suppressor genes, particularly through epigenetic alterations like promoter CpG-island hypermethylation, contribute to the development and progression of cutaneous malignant melanoma. This study identified 24 bona fide tumor suppressor genes affected by promoter CpG-island hypermethylation in CMM, outlining their functional roles in processes such as cell proliferation, apoptosis, growth, senescence, angiogenesis, migration, invasion, and metastasis. These findings provide further insight into the impact of tumor suppressor genes on the progression of cutaneous malignant melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Amisha Bharti, Amrita Ghosh Kar, Deepika Singh, Mumtaz Ahmad Ansari, Mallika Tewari, Gopeshwar Narayan, Sunita Singh
Summary: This study investigated the expression profile and promoter methylation status of BNIP3 in gallbladder cancer (GBC). The results demonstrated a down regulation of BNIP3 and frequent hypermethylation of its promoter in GBC samples. The study suggests that promoter hypermethylation may be a common mechanism for the downregulation of BNIP3 in GBC.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Leticia Colyn, Marina Barcena-Varela, Gloria Alvarez-Sola, M. Ujue Latasa, Iker Uriarte, Eva Santamaria, Jose M. Herranz, Alvaro Santos-Laso, Maria Arechederra, Mikel Ruiz de Gauna, Patricia Aspichueta, Matteo Canale, Andrea Casadei-Gardini, Maria Francesconi, Simone Carotti, Sergio Morini, Leonard J. Nelson, Maria J. Iraburu, Chaobo Chen, Bruno Sangro, Jose J. G. Marin, Maria L. Martinez-Chantar, Jesus M. Banales, Robert Arnes-Benito, Meritxell Huch, John M. Patino, Altaf A. Dar, Mehdi Nosrati, Julen Oyarzabal, Felipe Prosper, Jesus Urman, Francisco Javier Cubero, Christian Trautwein, Carmen Berasain, Maite G. Fernandez-Barrena, Matias A. Avila
Summary: The study suggests that dual targeting of G9a and DNMT1 with epigenetic small molecule inhibitors such as CM272 may be a potential strategy to treat cholangiocarcinoma, inhibiting the growth of CCA cells and synergizing with other drugs, showing significant antagonistic effects on CCA tumor progression.
Article
Biochemistry & Molecular Biology
Miki Bundo, Junko Ueda, Yutaka Nakachi, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto
Summary: Bipolar disorder is characterized by repeated mood swings and associated with genetic factors, but the underlying molecular mechanisms and the influence of environmental factors remain largely unknown. This study analyzed DNA methylation in neuronal and non-neuronal nuclei in the prefrontal cortex of BD patients, revealing decreased DNA methylation at promoters in both cell types. Gene Ontology analysis showed enrichment of molecular motor-related genes in neurons, chemokines in both cell types, and ion channel- and transporter-related genes in nonneurons.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Liping Tang, Shasha Zhu, Weiyan Peng, Xuedong Yin, Cui Tan, Yaying Yang
Summary: The protein expression of MAPK10 is significantly downregulated in HCC patients compared to normal tissues, and its negative expression is correlated with advanced tumor stage, more microsatellite nodules, higher serum AFP, and shorter overall survival time in HCC patients. MAPK10 is frequently methylated in HCC, and its methylation is associated with silenced or downregulated expression.
Article
Oncology
Monica Mancini, Margherita Grasso, Livio Muccillo, Federica Babbio, Francesca Precazzini, Ilaria Castiglioni, Valentina Zanetti, Francesca Rizzo, Christian Pistore, Maria Giovanna De Marino, Michele Zocchi, Valerio Del Vescovo, Valerio Licursi, Giorgio Giurato, Alessandro Weisz, Paola Chiarugi, Lina Sabatino, Michela Alessandra Denti, Ian Marc Bonapace
Summary: The study demonstrates that the interaction between DNMT3A and miRNAs plays a central role in the EMT process of prostate cancer, with key miRNAs such as the miR-200 family, miR-205, and miR-203 being down-regulated and hyper-methylated. Differential expression of DNMT3A isoforms and a regulatory feedback loop between miR-429 and DNMT3A were also identified during EMT. Additionally, miR-429 was shown to target DNMT3A and modulate the expression of EMT factors.
Article
Biochemistry & Molecular Biology
Jing Guo, Chen Chang, Li-Yan Yang, Hong-Qing Cai, Ding-Xiong Chen, Yu Zhang, Yan Cai, Juan-Juan Wang, Wen-Qiang Wei, Jia-Jie Hao, Ming-Rong Wang
Summary: The present study aimed to identify abnormal methylation genes associated with esophageal squamous cell carcinoma (ESCC). The study found that CXCL14 promoter was frequently hyper-methylated in ESCC tissues, and low expression of CXCL14 was associated with lower differentiation of patients. In addition to its immune regulation function, CXCL14 was observed to act as a tumor suppressor in ESCC cells. Therefore, increasing CXCL14 expression combined with inhibition of SRC or EGFR may be a promising therapeutic strategy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Chisaki Ikeda, Hiroaki Haga, Naohiko Makino, Tatsutoshi Inuzuka, Ayako Kurimoto, Toshiki Ueda, Akiko Matsuda, Yasuharu Kakizaki, Tetsuya Ishizawa, Toshikazu Kobayashi, Shinpei Sugahara, Michihiko Tsunoda, Kensei Suda, Yoshiyuki Ueno
Summary: This study isolated EVs from human bile using EDEG and performed proteomic analysis, identifying Claudin-3 as a useful biomarker for CCA. The diagnostic accuracy was high with AUC 0.945 and sensitivity and specificity of 87.5%.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Brian M. Ortmann, Natalie Burrows, Ian T. Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise H. Jordon, Olivia Lombardi, Ana Penalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan
Summary: The histone H3K4 methyltransferase SET1B plays a crucial role in the transcriptional activity of HIF target genes, and its loss results in impaired cell growth and tumor formation. Experimental findings demonstrate that SET1B accumulates on chromatin in hypoxia and is recruited to HIF target genes by the HIF complex.
Article
Chemistry, Analytical
Yu-Jen Cheng, Chih-Hung Wang, Keng-Fu Hsu, Gwo-Bin Lee
Summary: In this study, an integrated microfluidic system was developed to automatically capture and quantify the methylation level of cfDNA. The system achieved high capture rate and low limit of quantification, allowing for efficient detection of methylated cfDNA from plasma samples in a short time.
ANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Editorial Material
Hematology
Ian J. Majewski
Summary: The study investigates how loss of the tumor suppressor gene Cux1 modulates DNA repair activity in the hematopoietic compartment and contributes to the pathogenesis of therapy-related myeloid neoplasms.
Article
Gastroenterology & Hepatology
Eunhyang Park, Jeong Eun Yoo, Ho Kyoung Hwang, Chang Moo Kang, Choong-Kun Lee, Min Hwan Kim, Seungmin Bang, Young Nyun Park
Summary: The study identified factors related to prognosis in pancreatic ductal adenocarcinoma (PDAC), such as keratin 81 expression and stromal features. Combining tumor histopathology with keratin 81 expression may be useful for predicting the prognosis of PDAC.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ha Young Woo, Hyungjin Rhee, Jeong Eun Yoo, Se Hoon Kim, Gi Hong Choi, Do Young Kim, Hyun Goo Woo, Hye Sun Lee, Young Nyun Park
Summary: Metastatic HCCs to various organs exhibit different pathological characteristics, with VETC and MTM subtypes associated with lung metastases, and K19 expression, EMT-high features, fibrous tumor stroma, and high immune cell infiltration linked to lymph node metastases.
LIVER INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Jun Ho Song, Taejun Yoon, Sun-Mi Lee, Chin Hee Mun, Dasol Kim, Jieun Han, Ju-Won Kim, Yonghee Bae, Taehee Kim, Young Nyun Park, Mann-Ho Cho, Yong-Beom Park, Kyung-Hwa Yoo
Summary: Recent studies have shown that 2D germanium telluride nanosheets coated with polyvinylpyrrolidone (PVP) have potential applications in nanomedicine for multispectral optoacoustic tomography and fluorescence imaging and therapy of inflammatory bowel disease. These nanosheets exhibit broad optical absorption in visible and near-infrared ranges, providing deeper tissue images than other materials. Additionally, when orally administered, they show therapeutic efficacy similar to or higher than traditional medication for inflammatory diseases in the gastrointestinal tract.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Gastroenterology & Hepatology
Hyeo Seong Hwang, Jeong Eun Yoo, Dai Hoon Han, Jin Sub Choi, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Soon Il Kim, Gi Hong Choi, Young Nyun Park
Summary: This study found that EpCAM+/CD90+ CTCs can serve as key biological markers in the selection of LT candidates and postoperative management in patients with hepatocellular carcinoma.
Article
Gastroenterology & Hepatology
Youngsic Jeon, So Mee Kwon, Hyungjin Rhee, Jeong Eun Yoo, Taek Chung, Hyun Goo Woo, Young Nyun Park
Summary: In this study, we performed an integrative analysis of transcriptome profiles associated with radiopathologic features to identify four subtypes of primary liver cancers (LCs). Our findings revealed intermediate subtypes between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), and provided insights into their molecular spectrum and progression mechanisms.
Article
Cell Biology
Binny Khandakar, Jun-Ru Liu, Swan Thung, Ying Li, Hyungjin Rhee, Alexander C. Kagen, Tommy Sun-Wing Tong, Young Nyun Park, Neil Theise, Irene Oi-Lin Ng
Summary: This study presented three rare cases of intrahepatic biliary EBV-associated LEL tumors, with a distinctly benign biliary epithelial component, low proliferation index, and good prognosis. These cases with unique features warrant further investigation and may require revision of the current nomenclature.
Article
Cardiac & Cardiovascular Systems
Yu Rim Shin, Seung Up Kim, Sak Lee, Jae Young Choi, Han Ki Park, Jeong Eun Yoo, Young Nyun Park
Summary: Patients with Fontan circulation have a high incidence of liver fibrosis and cirrhosis. This study found that transient elastography (TE) and the enhanced liver fibrosis (ELF) test were unable to predict the degree of liver fibrosis in Fontan patients. Elevated N-terminal pro-brain natriuretic peptide levels and ventricular end-diastolic pressure may be associated with advanced liver fibrosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ja Kyung Yoon, Jin-Young Choi, Hyungjin Rhee, Young Nyun Park
Summary: HCC is a diverse group of tumors in terms of histology, genetics, and protein expression. Advancements in imaging techniques have made imaging diagnosis a critical part of managing HCC in the clinical setting. There is increasing evidence of correlation between imaging phenotypes and histologic, molecular, and genetic characteristics of different HCC subtypes. Further research on radiological characteristics of HCC subtypes may enable non-invasive diagnosis and serve as biomarkers for prognosis, molecular characteristics, and therapeutic response.
EUROPEAN RADIOLOGY
(2022)
Review
Medicine, General & Internal
Taek Chung, Young Nyun Park
Summary: Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver malignancy with distinct histopathologic features and molecular profiles. The classification of small duct type and large duct type iCCA provides important insights into the tumor behavior and prognosis. Understanding the tumor microenvironment and genomic characteristics can help develop precision therapeutics for patients with iCCA.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yeon Seung Chung, Youngsic Jeon, Jeong Eun Yoo, Taek Chung, Hyang Joo Ryu, Hyunki Kim, Hyungjin Rhee, Young Nyun Park
Summary: In this study, a method was developed to differentiate intrahepatic cholangiocarcinomas (iCCAs) from adenocarcinomas originating from extrahepatic organs adjacent to the liver. The combination of albumin mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) staining for filamin-A and cytokeratin 19 (CK19) showed better diagnostic performance than albumin ISH alone. The newly developed iCCA-score consisting of these three markers can accurately differentiate iCCA from extrahepatic adenocarcinomas.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Choong-kun Lee, Hong Jae Chon, Jaekyung Cheon, Myung Ah Lee, Hyeon-Su Im, Joung-Soon Jang, Min Hwan Kim, Sejung Park, Beodeul Kang, Moonki Hong, Jin Won Kim, Hyung Soon Park, Myoung Joo Kang, Young Nyun Park, Hye Jin Choi
Summary: This study evaluated the clinical activity of FOLFOX plus anti-HER2 antibody trastuzumab as a second-line or third-line treatment for HER2-positive biliary tract cancer. The overall response rate was 29.4% and the disease control rate was 79.4%. The treatment showed promising activity with acceptable toxicity in HER2-positive biliary tract cancer.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jae Hyon Park, Young Nyun Park, Myeong-Jin Kim, Mi-Suk Park, Jin-Young Choi, Yong Eun Chung, Hyungjin Rhee
Summary: This retrospective study analyzed patients who underwent resection for hepatocellular carcinoma (HCC) between January 2014 and December 2019. The results showed a strong association between fatty liver disease and metabolic syndrome with steatotic and steatohepatitic HCCs.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Sung Hwan Lee, Jaekyung Cheon, Seoyoung Lee, Beodeul Kang, Chan Kim, Hyo Sup Shim, Young Nyun Park, Sanghoon Jung, Sung Hoon Choi, Hye Jin Choi, Choong-kun Lee, Hong Jae Chon
Summary: The study identified that ARID1A alteration predicts the response and resistance to chemotherapy in advanced biliary tract cancer, and patients with ARID1A alteration have worse clinical outcomes.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Anatomy & Morphology
Michel Kmeid, Young Nyun Park, Taek Chung, Richard. R. R. Pacheco, Mustafa Erdem Arslan, Hwajeong Lee
Summary: The methylated SEPT9 DNA (mSEPT9) in plasma is an FDA-approved screening biomarker in colorectal cancer and is emerging as a promising diagnostic and prognostic biomarker in hepatocellular carcinoma (HCC). In this study, the SEPT9 protein expression in various hepatic tumors was evaluated using immunohistochemistry (IHC), and its correlation with demographics, risk factors, tumor characteristics, and oncologic outcomes was analyzed. The findings suggest that SEPT9 may be implicated in liver carcinogenesis and that SEPT9 staining by IHC could serve as an adjunct diagnostic biomarker with potential prognostic ramifications.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
