Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Health Care Sciences & Services
Huiping Wu, Ying Wang, Haiyan Fu, Lili Ji, Na Li, Dan Zhang, Longxiang Su, Zhansheng Hu
Summary: The study aimed to investigate the potential neuroprotective effects of Maresin1 (MaR1) on microglia-induced neuroinflammation in sepsis-induced cognitive impairment and explore its anti-inflammatory mechanism. The results showed that MaR1 significantly ameliorated cognitive dysfunction and inhibited neuroinflammation by suppressing the activations of NLRP3 and TLR4-NF-κB signal pathways.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Shuaibing Hou, Xiaomin Wang, Tengxiao Guo, Yanjie Lan, Shengnan Yuan, Shuang Yang, Fei Zhao, Aizhong Fang, Na Liu, Wanzhu Yang, Yajing Chu, Erlie Jiang, Tao Cheng, Xiaojian Sun, Weiping Yuan
Summary: This study reveals that PHF6 plays a significant role in myeloid leukemia by inhibiting NF-κB signaling pathway to suppress cell proliferation and induce apoptosis. The authors also discovered that PHF6 acts as a tumor suppressor gene in lymphocytic leukemia but as an oncogene in myeloid leukemia.
Article
Immunology
Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin, Ye Xiong
Summary: The study found that hydroxychloroquine (HCQ) can improve neurological recovery in mice post-TBI by inhibiting the inflammatory response through the TLR4/NF-kappa B signaling pathway. HCQ reduces the expression of proinflammatory cytokines, attenuates blood-brain barrier (BBB) disruption and brain edema, and upregulates tight junction expression. This suggests that HCQ could be a potential therapeutic agent for TBI treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Qiaoyan Wu, Chengyu Zou
Summary: Microglial dysfunction, specifically the activation of the NF-kappa B pathway and RIPK1 kinase activity, plays a crucial role in exacerbating neurodegenerative diseases through increased neurotoxicity and reactive oxygen species (ROS) accumulation. Understanding the mechanistic links between these factors and their impact on microglial homeostasis is essential for developing therapeutic strategies.
Article
Biochemistry & Molecular Biology
Wahyu Dwi Saputra, Hiroki Shono, Yusuke Ohsaki, Halima Sultana, Michio Komai, Hitoshi Shirakawa
Summary: The study demonstrated that GGOH could alleviate LPS-induced microglial inflammation by targeting the NF-kB signaling pathway, similar to menaquinone-4. This suggests a potential therapeutic role for GGOH in neurodegenerative diseases associated with inflammatory reactions in microglial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pei-Lin Li, Xiao-Xue Zhai, Jun Wang, Xiang Zhu, Lin Zhao, Shuang You, Chun-Yan Sang, Jun-Li Yang
Summary: Various physiological and pathological changes are associated with neurodegenerative diseases, and neuroinflammation is a major factor in their occurrence and progression. This study evaluated the inhibitory effect of two ferulic acid derivatives (TJZ-1 and TJZ-2) on neuroinflammation induced by lipopolysaccharide (LPS) in human HMC3 microglial cells. The results showed that both compounds significantly inhibited the production and expression of inflammatory markers and increased the level of an anti-inflammatory factor. Furthermore, they were found to inhibit the activation of NF-kappa B, a key regulator in neuroinflammation. These findings suggest that TJZ-1 and TJZ-2 could be potential anti-neuroinflammatory agents.
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon Go
Summary: In this study, the effects of Menthae Herba (MH) on the inflammatory response and molecular mechanisms in activated microglia were evaluated. The results showed that MH inhibited the production of proinflammatory enzymes and mediators, reduced reactive oxygen species (ROS) levels, and activated antioxidant signaling pathways. These findings suggest the potential therapeutic use of MH in neuroinflammatory diseases.
Article
Multidisciplinary Sciences
Ashley Prichard, Kristie M. Garza, Avni Shridhar, Christopher He, Sara Bitarafan, Alyssa Pybus, Yunmiao Wang, Emma Snyder, Matthew C. Goodson, Tina C. Franklin, Dieter Jaeger, Levi B. Wood, Annabelle C. Singer
Summary: Microglia transform in response to changes in neural activity and different frequencies of brain rhythms can affect microglial morphology and cytokine expression. Nuclear factor κB (NF-κB) plays a causal role in frequency-specific cytokine and microglial responses.
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Zhousheng Yang, Tianyu Li, Chunyan Wang, Mingyu Meng, Shenglan Tan, Lei Chen
Summary: Dihydromyricetin (DMY), a natural flavonoid compound extracted from Ampelopsis grossedentata, has been identified as a potential therapeutic chemical for treating atherosclerosis. This study investigates the mechanism by which DMY suppresses M1 macrophage polarization in atherosclerosis. The results showed that DMY treatment significantly reduced M1 macrophage markers and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe(-/-)) mice.
MEDIATORS OF INFLAMMATION
(2023)
Review
Cell Biology
Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei
Summary: Lck and nuclear factor-kappa B play crucial roles in the development and progression of autoimmune diseases and malignancies, and understanding their signaling pathways may lead to the identification of new therapeutic targets and approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Lei Li-Yan, Wang Rui-Cheng, Pan Ya-Lei, Yue Zheng-Gang, Zhou Rui, Xie Pei, Tang Zhi-Shu
Summary: The study showed that mangiferin significantly reduced the production of inflammatory cytokines and oxidative products, promoted the polarization of BV2 cells towards anti-inflammatory, and inhibited the activation of NF-kappa B and NLRP3 signaling pathways. Therefore, mangiferin has anti-neuroinflammatory properties by regulating microglial macrophage polarization and suppressing NF-kappa B and NLRP3 signaling pathways.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Chemistry, Medicinal
Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang
Summary: This study investigates the potential therapeutic use of stigmasterol for treating neuropathic pain. It finds that stigmasterol can regulate microglial M1/M2 polarization to alleviate neuropathic pain. The research demonstrates the modulatory effects of stigmasterol on pain-related markers and inflammatory factors in animal and cell experiments.
PHYTOTHERAPY RESEARCH
(2023)