Article
Gastroenterology & Hepatology
Xian Li, Yi-Ru Han, Xuefeng Xuefeng, Yong-Xiang Ma, Guo-Sheng Xing, Zhi-Wen Yang, Zhen Zhang, Lin Shi, Xin-Lin Wu
Summary: This study suggests a potential role of CENPK in promoting tumor proliferation and it may serve as a novel diagnostic and prognostic biomarker for CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Integrative & Complementary Medicine
Gen Liu, Zhi-gang Chen, Li-rong Yang, Yu-xia Rong, Qin Wang, Li Li, Qian-wei Lu, Ming-dong Jiang, Hong-yi Qi
Summary: In this study, it was found that Z-LIG selectively induced mitochondrial dysfunction in AML HL-60 cells by restoring NUR77 and NOR1. RNA sequencing revealed mitochondrial transcription and translation as potential targets of Z-LIG in inhibiting HL-60 cells. NUR77/NOR1 and Z-LIG reduced mitochondrial ATP and membrane potential and increased mitochondrial reactive oxygen species by downregulating mitochondrial transcription and translation-related proteins. Z-LIG demonstrated anti-AML activity in primary AML cells and mouse models.
Article
Biochemistry & Molecular Biology
Na-Ra Han, Seong-Gyu Ko, Hi-Joon Park, Phil-Dong Moon
Summary: This study demonstrated the effect of hydrogen sulfide (H2S) on the expression of OSM in neutrophils, showing that H2S can suppress OSM expression and potentially serve as a therapeutic agent for inflammatory disorders.
Article
Agriculture, Multidisciplinary
Chunni Zhang, Shaokai Du, Ruifang Liu, Wu Dai
Summary: Piperonyl butoxide (PBO) significantly increases the toxicity of clothianidin in the clothianidin-resistant population of Bradysia odoriphaga. The population with resistance has higher P450 enzyme activity and overexpression of four P450 genes. Tissue-specific expression analysis suggests that these genes are highly expressed in the midgut and/or Malpighian tubules. Knockdown of three P450 genes increases the susceptibility of B. odoriphaga to clothianidin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Na-Ra Han, Seong-Gyu Ko, Hi-Joon Park, Phil-Dong Moon
Summary: This study investigated the mechanism of oncostatin M (OSM) production in neutrophils and found that dexamethasone can downregulate OSM synthesis by inhibiting the PI3K/Akt/NF-kB signaling cascade. This highlights the potential of dexamethasone as a treatment for inflammatory diseases.
Article
Endocrinology & Metabolism
Bolun Cheng, Chujun Liang, Xuena Yang, Ping Li, Li Liu, Shiqiang Cheng, Yumeng Jia, Lu Zhang, Mei Ma, Xin Qi, Yao Yao, Xiaomeng Chu, Jing Ye, Chao Lu, Xiong Guo, Yan Wen, Feng Zhang
Summary: The study identified TP63 as a novel susceptibility gene for KBD, and demonstrated that the inhibition of TP63 suppresses chondrocyte apoptosis and partly facilitates chondrogenesis. The combination of SNP genotyping and molecular biology techniques provides a useful tool for understanding the biological mechanism and conducting differential diagnosis studies of KBD and OA.
Article
Agriculture, Multidisciplinary
Li Wang, Junshu Zhu, Li Cui, Qinqin Wang, Weiling Huang, Qingjie Yang, Xuejiao Ji, Changhui Rui
Summary: The study found that UGTs play an important role in sulfoxaflor resistance in Aphis gossypii, with higher activity in Sul-R strain compared to Sus strain, and multiple UGT genes showing significantly upregulated expression levels.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
H. Liang, H. Hu, D. Shan, J. Lyu, X. Yan, Y. Wang, F. Jian, X. Li, W. Lai, H. Long
Summary: CGRP is upregulated in trigeminal neurons and SGCs following orofacial pain induction. Knockdown of CGRP reduces pain and its expression in neurons and SGCs. CGRP upregulates inducible nitric oxide synthase in SGCs through p38 signaling pathway, leading to a positive-feedback neuron-glia crosstalk mediated by CGRP.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Engineering, Chemical
Na-Ra Han, Seong-Gyu Ko, Hi-Joon Park, Phil-Dong Moon
Summary: This study investigated the regulation of oncostatin M (OSM) expression in neutrophil-like differentiated HL-60 cells by the pentacyclic triterpenoid ursolic acid (UA). The results showed that UA can suppress the production of OSM, suggesting its potential use in the treatment of inflammatory diseases.
Article
Biochemistry & Molecular Biology
Yuanxue Yang, Ailing Duan, Cong Zhang, Yun Zhang, Aiyu Wang, Chao Xue, Hongyan Wang, Ming Zhao, Jianhua Zhang
Summary: Aphis craccivora, a pest that threatens legumes, has developed resistance to various insecticides. This study investigates the role of ABC transporters in the tolerance of imidacloprid in A. craccivora. It identifies fifty-eight ABC transporters and finds that inhibiting certain ABC transporters increases the toxicity of imidacloprid. Moreover, the study shows that knockdown of specific ABC transporters increases the mortality of A. craccivora to imidacloprid.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Lena Hoelzen, Jan Mitschke, Claudia Schoenichen, Maria Elena Hess, Sophia Ehrenfeld, Melanie Boerries, Cornelius Miething, Tilman Brummer, Thomas Reinheckel
Summary: This study suggests that proteases can act synergistically with PI3K inhibition in breast cancer cells, leading to enhanced therapeutic outcomes. Through a series of experiments, the researchers identified Usp7, Metap1, and Metap2 as key proteases that exhibit synthetic lethal effects when combined with PI3K inhibitors.
Article
Cell Biology
Meng-Di Wu, Yuan-Ying Zhang, Shu-Ying Yi, Bei-Bei Sun, Jing Lan, Han-Ming Jiang, Gang-Ping Hao
Summary: In this study, the effects of Acetylshikonin (ASK) on apoptosis and autophagy in acute myeloid leukemia (AML) cells were investigated. The results showed that ASK induced apoptosis through the mitochondrial pathway and promoted autophagy via the LKB1/AMPK signaling pathway. ASK also suppressed the PI3K/Akt/mTOR pathway. These findings suggest that ASK-induced apoptosis in HL-60 cells is dependent on the activation of autophagy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wenzhong Shen, Shanni Cao, Jinhui Liu, Wenqing Zhang, Jie Chen, Jian-Feng Li
Summary: Rice is a staple food for over half of the global population, while the brown planthopper is a major destructive insect pest of rice plants. Research has shown that by introducing a specific miRNA, rice plants can be genetically modified to resist brown planthopper infestations through RNA interference technology, without adverse effects on plant development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Julia Korzuch, Monika Rak, Katarzyna Balin, Maciej Zubko, Olga Glowacka, Mateusz Dulski, Robert Musiol, Zbigniew Madeja, Maciej Serda
Summary: This paper presents two water-soluble fullerene nanomaterials developed for non-viral siRNA transfection. One fullerene is an efficient siRNA transfection agent, while the other is inactive, likely due to the formation of an extremely stable complex with siRNA.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ran Wang, Wunan Che, Cheng Qu, Jinda Wang, Chen Luo
Summary: Bemisia tabaci, or the tobacco whitefly, is a major agricultural pest that causes significant damage to crops worldwide. In China, this pest has developed resistance to commonly used insecticides, leading to the increased use of cyantraniliprole as an alternative. The overexpression of the CYP4G68 gene was found to confer cyantraniliprole resistance in a lab-selected resistant strain. Field-sampled populations across China also showed varying levels of resistance to cyantraniliprole, with CYP4G68 overexpression identified as a significant factor in the resistance development in two populations.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)