Article
Biotechnology & Applied Microbiology
Caimei Wang, Yiyuan Wang, Congrong Liu, Xiaoyu Meng, Zhongxia Hang
Summary: This study reveals the important role of KNTC1 in the development of cervical cancer and identifies the mechanism by which KNTC1 promotes cervical cancer through MMP9 and MMP2-mediated reduction in tumor cell invasion and migration abilities.
Article
Veterinary Sciences
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello
Summary: This study conducted immunohistochemical and biochemical analysis on MMPs and TIMPs in BPV-2 positive bovine cutaneous fibropapillomas, revealing their significant role in tumor development and their unbalanced expression in tumor samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Oncology
Ze Wu, Qiongqiong Jia, Boqun Liu, Lanlan Fang, Peter C. K. Leung, Jung-Chien Cheng
Summary: This study reveals that upregulation of NPFFR2 is associated with poor overall survival in epithelial ovarian cancer (EOC). NPFF and NPFFR2 are expressed in human EOC cells, with higher levels in SKOV3 cells compared to CaOV3 and OVCAR3 cells. NPFF treatment stimulates cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway. Blocking ERK1/2 signaling abolishes the NPFF-induced MMP-9 expression and cell invasion.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mohamed El-Sherbiny, Hoda Atef, Ghada M. Helal, Rasha Hamed Al-Serwi, Hany A. Elkattawy, Gehan Ahmed Shaker, Eman Said, Moaz Abulfaraj, Marzough A. Albalawi, Nehal M. Elsherbiny
Summary: Aging is a natural physiological process that negatively affects various body organs and well-being. The use of Vitamin K2 shows promise in improving liver function and suppressing inflammatory and fibrotic biomarkers.
Article
Biochemistry & Molecular Biology
Arno Kirchhain, Asta Zubriene, Visvaldas Kairys, Federico Vivaldi, Andrea Bonini, Denise Biagini, Delio Santalucia, Daumantas Matulis, Fabio Di Francesco
Summary: Matrix metalloproteinases play a crucial role in cancer progression and metastasis, and molecular probes have been successfully used to study their activity. In this study, a series of MMP-2 and MMP-9 binding probes were synthesized, showing high selectivity against MMP-2 and potential for sensor fabrication. The experimental results were confirmed by molecular modeling, indicating the potential application of these probes for targeted enzyme detection.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
Xinying Zhou, Linmiao Lie, Yao Liang, Hui Xu, Bo Zhu, Yingqi Huang, Lijie Zhang, Zelin Zhang, Qianna Li, Qi Wang, Zhenyu Han, Yulan Huang, Honglin Liu, Shengfeng Hu, Chaoying Zhou, Qian Wen, Li Ma
Summary: This study reveals the significant role of GSK-3alpha/beta pathway in regulating immune response of macrophages to Mycobacterium tuberculosis infection. It also demonstrates that PKC-delta and mTOR can influence the activation of GSK-3alpha/beta and subsequently regulate the expression of MMP-1/9. These findings provide new insights into the immune escape mechanism of tuberculosis and the crosstalk between critical signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Aya Khaleel, Ahmed R. El-Sheakh, Ghada M. Suddek
Summary: This study aimed to explore the possible protective effect of celecoxib, a cyclooxygenase-2 inhibitor, on immunological responses elicited in a mouse model of autoimmune hepatitis. Results showed that celecoxib significantly protected the liver from ConA-induced damage, improved antioxidant capacity, and inhibited inflammation and apoptosis. Moreover, celecoxib modulated multiple signaling pathways, leading to liver protection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Haiyan Zheng, Yu Pei, Yuan-Lin He, Yi Liu, Minqi Chen, Pengzhi Hong, Chunxia Zhou, Zhong-Ji Qian
Summary: Sulfated polysaccharides from red algae have antitumor activities. In this study, it was found that the sulfated polysaccharide from Gelidium crinale can inhibit the migration and invasion of human fibrosarcoma cells and suppress the expression and activity of MMP-9 by regulating NF-kappa B, MAPK, and mTOR/PI3K/Akt signaling pathways. This suggests that GNP may serve as an MMP-9 inhibitor for preventing tumor metastasis.
Article
Biochemistry & Molecular Biology
Joana Mota, Rosa Direito, Joao Rocha, Joao Fernandes, Bruno Sepodes, Maria Eduardo Figueira, Anabela Raymundo, Ana Lima, Ricardo Boavida Ferreira
Summary: The study isolated and characterized an MMP-2 and -9 inhibitor from Lupinus albus, showing its efficacy in inhibiting MMP-9 activity in colon cancer cells and significantly reducing colitis symptoms in a mouse model. This novel type of MMP inhibitor in lupine, edible and proteinaceous in nature, holds high potential for application as a nutraceutical or functional food targeting pathologies related to high MMP-9 activity in the digestive system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Luo Qiong, Jun Yin
Summary: The study shows that the upregulated expression of ORM1 in breast cancer tissues and cell lines enhances cell proliferation and migration. In contrast, down-regulation of ORM1 inhibits the expression of MMP-2 and MMP-9, as well as the activation of the AKT/ERK signaling pathway. These findings suggest that ORM1 may be a potential therapeutic target for breast cancer and play a role in promoting epirubicin resistance.
Article
Medicine, General & Internal
Marwa Ben Ali Gannoun, Nozha Raguema, Hedia Zitouni, Meriem Mehdi, Ondrej Seda, Touhami Mahjoub, Julie L. Lavoie
Summary: This study found an increased frequency of heterozygous MMP-9 -1562 C/T genotype carriers in women with preeclampsia compared to healthy controls, suggesting it could be a genetic risk factor for preeclampsia in Tunisian women. However, there was no significant difference in the frequency distribution of the allele and genotype of MMP-2 -735 C/T polymorphism between healthy pregnant women and those with preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Isabel Santos, Ana Lima, Joana Mota, Patricia Rebelo, Ricardo Boavida Ferreira, Laurentina Pedroso, Maria Adelia Ferreira, Isabel Sousa
Summary: This study found that fermentation with specific lactic acid bacteria produced peptides with antibacterial activity, one of which derived from beat casein. This peptide showed effectiveness against various pathogens, inhibited metalloproteases, and reduced cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Bharath Kumar Velmurugan, Jen-Tsun Lin, B. Mahalakshmi, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: This study demonstrates that dehydrocrenatidine treatment significantly reduces the motility, migration, and invasion of head and neck cancer cells, decreases MMP-2 expression, and inhibits cell migration by reducing the phosphorylation of ERK1/2 and JNK1/2. Combined treatment with inhibitors enhances the anti-metastatic effects of dehydrocrenatidine.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Huimin Shi, Renyu Kong, Xu Miao, Lingshan Gou, Xin Yin, Yuning Ding, Xiliang Cao, Qingyong Meng, Maosheng Gu, Feng Suo
Summary: Reduced levels of PPP1R3G may contribute to the progression of pre-eclampsia by suppressing trophoblast invasion and migration and targeting the Akt/MMP-9 signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sun Young Park, Zhengwei Cui, Beomjin Kim, Geuntae Park, Young-Whan Choi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Sun-Young Park, Eui-Hyoung Hwang, Jae-Heung Cho, Koh-Woon Kim, In-Hyuk Ha, Me-riong Kim, Kibong Nam, Min Ho Lee, Jun-Hwan Lee, Namkwen Kim, Byung-Cheul Shin
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Sun Young Park, Min Hyun Cho, Mei Li, Ke Li, Geuntae Park, Young-Whan Choi
MOLECULAR MEDICINE REPORTS
(2020)
Article
Nanoscience & Nanotechnology
Sun Young Park, Beomjin Kim, Zhengwei Cui, Geuntae Park, Young-Whan Choi
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Sun Young Park, Guo Lu, Beomjin Kim, Woo Chang Song, Geuntae Park, Young-Whan Choi
Article
Chemistry, Medicinal
Eun-Sook Jun, Yeong Jin Kim, Hyung-Hoi Kim, Sun Young Park
Article
Chemistry, Physical
Beomjin Kim, Woo Chang Song, Sun Young Park, Geuntae Park
Summary: The green synthesis of silver and gold nanoparticles using marine algae extract has attracted attention due to its eco-friendly nature. The nanoparticles showed catalytic activity for degrading organic dyes, following pseudo-first order kinetics.
Article
Plant Sciences
Joong Suk Jeon, He Mi Kang, Ju Ha Park, Jum Soon Kang, Yong Jae Lee, Young Hoon Park, Byoung Il Je, Sun Young Park, Young Whan Choi
Summary: The extracts from KC showed significant photoprotective effects by improving keratinocyte viability, reducing apoptosis, and melanin production, offering potential for developing skin-whitening and photoprotective agents.
Article
Chemistry, Multidisciplinary
Sun Young Park, Woo Chang Song, Beomjin Kim, Jin-Woo Oh, Geuntae Park
Summary: Nano-GO induces EMT in human RPE cells by regulating phospholipase D signaling, enhancing cell migration ability and collagen gel contraction, leading to intracellular ROS generation. This study provides evidence of adverse health effects of Nano-GO on RPE cells.
Article
Chemistry, Medicinal
Sun Young Park, Hye Mi Kang, Woo Chang Song, Jin-Woo Oh, Geuntae Park, Young-Whan Choi
Summary: In this study, stable and monodisperse PT-functionalized Au nanostructures (PT-AuNSs) were successfully synthesized using Plocamium telfairiae extract. PT-AuNSs exhibited excellent biological reduction properties and showed inhibitory effects on adipogenesis in immature adipocytes while inducing brown adipogenesis.
Article
Biochemistry & Molecular Biology
Sun Young Park, Hye Mi Kang, Jin-Woo Oh, Young-Whan Choi, Geuntae Park
Summary: This study investigated the effects and mechanisms of cucurbitacins B, E, and I on the browning of white adipocytes. The results showed that cucurbitacins B, E, and I can promote the browning of white adipocytes and increase energy expenditure, with better results when combined with PLD2 inhibition. These findings provide new insights for the development of anti-obesity agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sun Young Park, He Mi Kang, Geuntae Park, Jin-Woo Oh, Young-Whan Choi
Summary: This study investigated the role of phospholipase D (PLD) in retinal ischemia-reperfusion (I/R) injury and found that inhibiting PLD1 and PLD2 can protect against oxidative damage and regulate ferroptosis and pyroptosis, two types of cell death pathways.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Nutrition & Dietetics
Sun Young Park, Ji Eun Kim, He Mi Kang, Hee Jin Song, Nam Jun Kang, Dae Youn Hwang, Young-Whan Choi
Summary: This study investigated the anti-obesity effects of Cucumis melo var. gaettongchamoe (CG) in mice fed a high-fat diet. The results showed that mice receiving CG water extract treatment exhibited reduced body weight and serum lipid levels compared to the control group. CGWE administration also led to reductions in abdominal fat content, adipocyte size, and inflammatory mediators, while promoting hepatic lipolysis. CGWE may serve as a potential natural anti-obesity agent.
Article
Biochemistry & Molecular Biology
Lu Guo, Jum Soon Kang, Young Hoon Park, Beong Il Je, Yeong Jae Lee, Nam Jun Kang, Sun Young Park, Dae Youn Hwang, Young Whan Choi
Article
Materials Science, Ceramics
Minh-Tan Ha, Yun Ji Shin, Si-Young Bae, Sun-Young Park, Seong-Min Jeong
JOURNAL OF THE KOREAN CERAMIC SOCIETY
(2019)