Journal
ONCOLOGY REPORTS
Volume 31, Issue 2, Pages 533-539Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2013.2909
Keywords
Wnt1 inducible signalling pathway protein-2; CCN5; epithelial-mesenchymal transition; angiogenesis; cellular migration; metastasis
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Funding
- Cancer Research Wales
- Albert Hung Foundation
- Cardiff University
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Wnt1 inducible signalling pathway protein-2 (WISP-2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family. This family of members has been shown to play multiple roles in a number of pathophysiological processes, including cell proliferation, adhesion, wound healing, extracellular matrix regulation, epithelial-mesenchymal transition, angiogenesis, fibrosis, skeletal development and embryo implantation. Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma. Notably, its roles in cancer appear to vary depending on cell/tumour type and the microenvironment. The striking difference in the structure of WISP-2 in comparison with the other 2 family members may contribute to its difference in functions, which leads to the hypothesis that WISP-2 may act as a dominant-negative regulator of other CCN family members. In the present review, we summarise the roles, regulation and underlying mechanism of WISP-2 in human cancers.
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