Article
Multidisciplinary Sciences
T. Kloskowski, K. Szeliski, K. Krzeszowiak, Z. Fekner, L. Kazimierski, A. Jundzill, T. Drewa, M. Pokrywczynska
Summary: The study found that Mumio exhibited significant cytotoxicity to urinary bladder cancer cells, while having minimal impact on normal cells. Mumio works by inhibiting the cell cycle of cancer cells and inducing apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Anatomy & Morphology
Xiong Ni, Fu-Sheng Shang, Ting-Feng Wang, De-Jun Wu, Da-Gui Chen, Biao Zhuang
Summary: Research has shown that ellagic acid (EA), found in fruits and foods, is effective in treating breast, colon, and bladder cancer. However, the therapeutic mechanism of EA for colon cancer is still unclear due to its complexity. In this study, cell counting, Western blotting, flow cytometry, and luciferase reporter assays were used to investigate the effects of EA on colon cancer cells (HCT116). The results revealed that EA promotes apoptosis, induces autophagy, and inhibits the growth of colon cancer through the AMPK/mTOR pathway.
Review
Biochemistry & Molecular Biology
Martina Cizmarikova, Radka Michalkova, Ladislav Mirossay, Gabriela Mojzisova, Martina Zigova, Annamaria Bardelcikova, Jan Mojzis
Summary: This review summarizes the role of ellagic acid (EA) as a potential therapeutic agent in cancer prevention and treatment by targeting key hallmarks of cancer. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy.
Article
Pharmacology & Pharmacy
Xiaohe Li, Kai Huang, Xiaowei Liu, Hao Ruan, Ling Ma, Jingjing Liang, Yunyao Cui, Yanhua Wang, Shuyang Wu, Hailong Li, Yuli Wei, Zeping Li, Jingjing Gao, Bo Yang, Xiaoping Li, Guang Yang, Honggang Zhou, Cheng Yang
Summary: Ellagic acid effectively alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting myofibroblast activation through suppressing the Wnt signaling pathway and promoting autophagy and apoptosis of myofibroblasts.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Eva Venusova, Adriana Kolesarova, Pavel Horky, Petr Slama
Summary: Punicalagin, a polyphenol found in pomegranate peel, has antioxidant, anti-inflammatory, anti-tumor activities, as well as hepatoprotective and anti-atherosclerotic effects.
Article
Oncology
Ji Yoon Kim, Yun Ju Choi, Ha-Jeong Kim
Summary: Ellagic acid inhibits pancreatic cancer cell growth by inducing apoptosis and suppresses migration by inhibiting epithelial mesenchymal transition. These findings suggest the potential utility of ellagic acid in pancreatic cancer treatment.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Plant Sciences
Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang, Zhaohui Zhang
Summary: The study demonstrates the significant protective effect of ellagic acid on beryllium sulphate-induced splenic toxicity in rats.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Environmental Sciences
Seda Iflazoglu Mutlu, Ismail Seven, Gozde Arkali, Nurgul Birben, Aslihan Sur Arslan, Mesut Aksakal, Pinar Tatli Seven
Summary: The study showed that lead negatively affected performance parameters in laying quails, but ellagic acid supplementation could improve this, especially at a dosage of 500 mg/kg. Ellagic acid not only enhanced the antioxidant defense system, but also suppressed lead-induced apoptosis by regulating the expression of apoptotic proteins.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Chun-Hui Ma, Ji-Feng Zhao, Xu-Guang Zhang, Chuan-Hua Ding, Hui-Hui Hao, Ying-Hui Ji, Li-peng Li, Zhen-Tao Guo, Wen-Shan Liu
Summary: This study discovered that ellagic acid is a competitive inhibitor of SHP2 with high inhibitory activity. It also demonstrated the inhibitory effects of ellagic acid on cancer cell proliferation and the synergistic effect when combined with a KRASG12C inhibitor. Furthermore, the study revealed the mechanism of ellagic acid's action through molecular docking and dynamics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Multidisciplinary Sciences
Ananya Bhattacharjee, Venkatrao H. Kulkarni, Manodeep Chakraborty, Prasanna V. Habbu, Animikh Ray
Summary: The study showed that ellagic acid (EA) has a nephroprotective effect in lead-induced nephrotoxicity by reducing inflammatory mediators, apoptosis, and autophagy pathway expression levels. It also restored biochemical markers in renal tissue.
Article
Environmental Sciences
Lalrinsanga Lalrindika, Maurya Khushboo, Baishya Bhanushree, Roy Dinata, Milirani Das, Nisekhoto Nisa, Sailo Lalrinzuali, Bose Manikandan, Laskar Saeed-Ahmed, Sanasam Sanjeev, Guruswami Gurusubramanian, Rema Momin Bidanchi, Meesala Krishna Murthy, Vikas Kumar Roy
Summary: This study investigates the potential antioxidative, anti-inflammatory, and anti-apoptotic effects of ellagic acid (EA) on lead-induced testicular and hepato-renal toxicity. EA administration reduces lead residue levels in tissues, improves liver and kidney function, restores redox homeostasis, and suppresses oxidative stress, inflammatory, and apoptotic responses.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Multidisciplinary
Shuaijun Lu, Hailong Tian, Bowen Li, Lei Li, Hao Jiang, Yajie Gao, Lin Zheng, Canhua Huang, Yuping Zhou, Zhongyan Du, Jia Xu
Summary: This study developed a novel nanoplatform for overcoming cancer chemotherapy resistance by using ellagic acid and copper coordination to effectively inhibit cancer cell stemness and enhance the efficacy of chemotherapy.
Review
Chemistry, Medicinal
Nazia Nazam, Nasimudeen R. Jabir, Iftikhar Ahmad, Saif A. Alharthy, Mohd Shahnawaz Khan, Rashid Ayub, Shams Tabrez
Summary: Cancer is a global health problem that is on the rise, and ovarian cancer is one of the leading causes of mortality worldwide. Current treatments for ovarian cancer have limited effectiveness and come with side effects, recurrence risk, and drug resistance. Therefore, there is a need for alternative, cost-effective, and safer therapeutic strategies.
Article
Environmental Sciences
Ming Qi, Nan Wang, Yuxin Xiao, Yuankun Deng, Andong Zha, Bie Tan, Jing Wang, Yulong Yin, Peng Liao
Summary: This study found that dietary ellagic acid supplementation can reduce hepatic injury caused by paraquat by modulating cecal microbial communities and antioxidant enzyme activity. This provides a novel nutritional therapeutic strategy for hepatic injury.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Multidisciplinary
Zhaoqiang Zhang, Chengjun Kang, Shing Bo Peh, Dongchen Shi, Fengxia Yang, Qixing Liu, Dan Zhao
Summary: This study synthesized two novel COFs using ellagic acid and triboronic acid-based building blocks, showing impressive C2H2 adsorption capacity and separation performance, expanding the application of COFs in gas separation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Valeria Sorrenti, Ilaria Buro, Valeria Consoli, Luca Vanella
Summary: This article highlights the abundant sources and various applications of bioactive compounds in agricultural products and their derived foods. These compounds, including terpenoids, polyphenols, alkaloids and other nitrogen-containing constituents, possess antioxidant and anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Antonio Malfa, Francesco Pappalardo, Natalizia Miceli, Maria Fernanda Taviano, Simone Ronsisvalle, Barbara Tomasello, Simone Bianchi, Federica Davi, Vivienne Spadaro, Rosaria Acquaviva
Summary: Brassica incana subsp. raimondoi is an endemic taxon found in eastern Sicily, growing on steep limestone cliffs. This research investigated the phytochemical profile, antioxidant properties, cytotoxicity, and Artemia salina toxicity of its leaf extract. The extract contained various phenolic acids, flavonoids, and carotenoids, and showed different antioxidant properties. It was non-toxic to normal cells, but exhibited cytotoxic effects on colon cancer and hepatoma cells. It also protected against oxidative stress caused by hydrogen peroxide. These findings suggest that B. incana subsp. raimondoi could be a potential source of bioactive molecules.
Article
Pharmacology & Pharmacy
Stefano Russo, Cristina Torrisi, Nunzio Cardullo, Vera Muccilli, Alfonsina La Mantia, Francesco Castelli, Rosaria Acquaviva, Maria Grazia Sarpietro
Summary: Colorectal cancer is a common tumor disease, and the use of naturally derived products for its treatment can be beneficial. The research focused on the encapsulation of ethyl protocatechuate (PCAEE) in solid lipid nanoparticles (SLN) to assess its effectiveness. SLN prepared with Tween 80 showed promising physicochemical properties and encapsulation efficiency, effectively penetrated and released PCAEE, and exhibited greater cytotoxicity on tumor cells. Therefore, further studies on this formulation for colorectal cancer treatment are suggested.
Article
Nanoscience & Nanotechnology
Grazia M. L. Consoli, Giuseppe Forte, Ludovica Maugeri, Valeria Consoli, Valeria Sorrenti, Luca Vanella, Gianpiero Buscarino, Simonpietro Agnello, Massimo Camarda, Giuseppe Granata, Loredana Ferreri, Salvatore Petralia
Summary: This study presents a novel method to prepare water-dispersible gold nanostructures with near-infrared localized surface plasmon resonance (LSPR) properties. These nanostructures were synthesized using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (CholCalix) forming micelles as a template. Characterization of the CholCalix-Au nanostructures was performed using UV-visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. The agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. The CholCalix-AuNPs demonstrated effective anticancer photothermal-induced effect on human breast cancer cells irradiated with biofriendly light at 808 nm.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Luca Vanella, Valeria Consoli, Ilaria Buro, Maria Gulisano, Manuela Stefania Giglio, Ludovica Maugeri, Salvatore Petralia, Angela Castellano, Valeria Sorrenti
Summary: Several studies have found that snail mucus has emollient, regenerative, and protective properties for maintaining healthy skin conditions. The mucus from Helix aspersa muller has shown beneficial properties like antimicrobial activity and wound repair capacity. By enriching snail mucus with antioxidant compounds derived from edible flower waste, researchers have demonstrated that the flower waste extract boosts the antioxidant activity of snail mucus, providing cytoprotective effects against UVB radiation in keratinocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Valeria Sorrenti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Federica Davi, Maria Fernanda Taviano, Rosaria Acquaviva, Giuseppe Antonio Malfa, Emilia Cavo, Paola Arena, Salvatore Ragusa, Francesco Cacciola, Yassine Oulad El Majdoub, Luigi Mondello, Natalizia Miceli
Summary: Our research team conducted a study on Brassica fruticulosa subsp. fruticulosa, an edible plant used for treating various ailments. We found that the leaf extract exhibited good antioxidant properties, with the secondary compounds being more potent than the primary ones. Further investigation revealed that the phenolic compounds in the extract possessed antioxidant properties and inhibited the proliferation of human colorectal epithelial adenocarcinoma cells.
Article
Biochemistry & Molecular Biology
Rosaria Acquaviva, Giuseppe Antonio Malfa, Rosa Santangelo, Simone Bianchi, Francesco Pappalardo, Maria Fernanda Taviano, Natalizia Miceli, Claudia Di Giacomo, Barbara Tomasello
Summary: This study investigated the phenolic profile and antioxidant properties of the leaf aqueous extract of wild artichokes grown in Sicily, Italy. The extract showed promising antioxidant power and was able to counteract oxidative stress caused by fatty acid exposure. It also modulated gene expression related to antioxidant defense and inflammation.
Correction
Immunology
G. Li Volti, V. Sorrenti, P. Murabito, F. Galvano, M. Veroux, A. Gullo, R. Acquaviva, A. Stacchiotti, F. Bonomini, L. Vanella, C. Di Giacomo
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Pharmacology & Pharmacy
Debora Santonocito, Ignazio Barbagallo, Alfio Distefano, Giuseppe Sferrazzo, Maria Vivero-Lopez, Maria Grazia Sarpietro, Carmelo Puglia
Summary: The aim of this study was to investigate the capability of MGN-NLC as a potential drug delivery system for ocular administration. The in vitro and ex vivo results showed that MGN-NLC exhibited no cytotoxic effects, maintained the antioxidant role of MGN, and could permeate and accumulate in ocular tissues. These findings suggest a potential application of MGN-NLC in the treatment of oxidative stress-related ocular diseases.
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Alfio Distefano, Angela Maria Amorini, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Giuseppe Lazzarino, Anna Nicolosi, Amer M. Alanazi, Concetta Saoca, Vincenzo Macaione, M'hammed Aguennouz, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Giovanni Li Volti, Giacomo Lazzarino
Summary: This study aimed to investigate the effects of lipoic acid on lipotoxicity and mitochondrial dynamics in an in vitro model of liver steatosis. The results showed that lipoic acid treatment reduced lipotoxicity and improved mitochondrial functions, suggesting its potential as a pharmacological tool for NAFLD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Alessandra Coscia, Lorenzo Riboldi, Elena Spada, Enrico Bertino, Stefano Sottemano, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo, Chiara Peila
Summary: This study investigated the effects of preeclampsia on activin A levels and found that the lactation phase had a significant effect on the concentration of activin A, while there were no significant differences between preeclamptic and normotensive women. The results suggest that the beneficial properties of breast milk can be maintained even if preeclampsia occurs.
Article
Biochemistry & Molecular Biology
Maria Concetta Tenuta, Monica Rosa Loizzo, Rosa Tundis, Annabelle Dugay, Chouaha Bouzidi, Arul Marie, Rosaria Acquaviva, Anna Rita Cappello, Brigitte Deguin
Summary: This study analyzed extracts of Cornus sanguinea and Cornus mas fruits and compared their inhibitory effects on key enzymes and their impact on health. Flavonoids, iridoids, and phenolic acids were identified as the main healthy compounds. The extracts from Cornus sanguinea showed significant antioxidant effects and promising enzyme inhibitory activity.
Article
Biochemistry & Molecular Biology
Maria Concetta Tenuta, Monica Rosa Loizzo, Rosa Tundis, Annabelle Dugay, Chouaha Bouzidi, Arul Marie, Rosaria Acquaviva, Anna Rita Cappello, Brigitte Deguin
Summary: In this study, extracts of Cornus sanguinea and Cornus mas fruits were analyzed using different extraction methods. The results showed that these extracts exhibited significant antioxidant activity and inhibited key enzymes associated with metabolic disorders. The findings suggest the potential use of Cornus species in the development of functional foods and nutraceuticals.
