Article
Biochemistry & Molecular Biology
Hyeong Sim Choi, Young-Kyun Kim, Pil-Young Yun
Summary: The combination treatment of cisplatin and cetuximab was found to inhibit cell proliferation and migration, decrease N-cadherin expression, and increase E-cadherin and claudin-1 expression in cisplatin-resistant cells. While this combination treatment did not induce apoptosis in cisplatin-resistant cells, it may be beneficial in treating oral cancer patients with cisplatin resistance by controlling cell migration and EMT-related proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Pallavi Mohapatra, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Falak Pahwa, Krushna Chandra Murmu, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Anshuman Dixit, Punit Prasad, Ranjan K. Nanda, Rupesh Dash
Summary: The study identified RRBP1 as a major driver of cisplatin-resistance in oral squamous cell carcinoma, regulating YAP1 expression to mediate chemoresistance, and demonstrated that targeting RRBP1 could reverse cisplatin-induced chemoresistance.
BRITISH JOURNAL OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Mingchuang Sun, Zhaoxing Li, Xiaoyuan Wang, Meirong Zhao, Yuan Chu, Zehua Zhang, Kang Fang, Ziying Zhao, Anqi Feng, Zhuyun Leng, Jianing Shi, Li Zhang, Tao Chen, Meidong Xu
Summary: TAOK3 promotes autophagy and chemoresistance in ESCC cells by phosphorylating KMT2C and promoting the interaction between KMT2C and ETV5. The inhibitor SBI-581 can suppress autophagy mediated by TAOK3 and synergize with cisplatin to treat ESCC.
Article
Chemistry, Medicinal
Hyeong Sim Choi, Young-Kyun Kim, Pil-Young Yun
Summary: This study aimed to identify the gene expressions related to cisplatin resistance in oral squamous cell carcinoma (OSCC) cell lines. RNA sequencing (RNA-Seq) analysis was used to determine differentially expressed genes and perform functional enrichment and signaling pathway analyses. Several genes related to cell adhesion molecules and proteoglycans in cancer pathways were found to have altered expression in cisplatin-resistant samples. These findings may provide new insights for improving the clinical therapeutic outcomes of OSCC.
Article
Immunology
Jusi Wang, Tingyu Chen, Weifeng Tang, Mingqiang Kang, Shuchen Chen
Summary: The study found that the rs2227282 (C > G) and rs2243283 (C > G) loci in the IL4 gene play protective roles in the development of ESCC, reducing the risk for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Yali Cheng, Shaoming Li, Ling Gao, Keqian Zhi, Wenhao Ren
Summary: Oral squamous cell carcinoma is a malignant tumor with low survival rate and high risk of metastasis and recurrence. Cisplatin-based chemotherapy is considered as the first-line treatment, but resistance to cisplatin limits its efficacy. This review outlines the mechanisms of cisplatin resistance and strategies to overcome it.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Teng Xu, Yuemei Yang, Zhihong Chen, Jinsong Wang, Xiaolei Wang, Yang Zheng, Chao Wang, Yachen Wang, Zaiou Zhu, Xu Ding, Junbo Zhou, Gang Li, Hongchuang Zhang, Wei Zhang, Yunong Wu, Xiaomeng Song
Summary: This study found that tumor necrosis factor alpha-induced protein 2 (TNFAIP2) plays a crucial role in cisplatin-based chemotherapy resistance in head and neck squamous cell carcinoma (HNSCC). TNFAIP2 protects cancer cells from cisplatin-induced apoptosis by inhibiting ROS-mediated c-JUN N-terminal kinase (JNK) phosphorylation. Moreover, TNFAIP2 competes with KEAP1 to prevent the degradation of NRF2, resulting in NRF2 accumulation and cisplatin resistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jiajie Ren
Summary: BRD4 is highly expressed in oral squamous cell carcinoma and regulates the efficacy of chemotherapy and radiotherapy by impacting PD-L1 expression. The BRD4 inhibitor JQ1 enhances the inhibitory effects of cisplatin and radiotherapy on cell proliferation and promotes apoptosis. Inhibition of BRD4 improves the anticancer effect of chemotherapy and radiotherapy by suppressing PD-L1 expression.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Oncology
Fumihiko Kinoshita, Yuka Oku, Shinkichi Takamori, Takatoshi Fujishita, Ryo Toyozawa, Kensaku Ito, Fumihiro Shoji, Tatsuro Okamoto
Summary: The efficacy and safety of N + GC in the second-line or later treatment of LSCC patients have been proven. However, the management of adverse events is essential.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Biochemistry & Molecular Biology
In-Song Lee, Dae-Won Kim, Ji-Hyeon Oh, Suk Keun Lee, Je-Yong Choi, Seong-Gon Kim, Tae-Woo Kim
Summary: This study evaluated the effects of 4-hexylresorcinol (4HR) on craniofacial growth, demonstrating its HDACi activity in Saos-2 cells and showing gender-specific responses in body weight and mandibular size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Kathryn Chen, Joel Yong, Roland Zauner, Verena Wally, John Whitelock, Mila Sajinovic, Zlatko Kopecki, Kang Liang, Kieran Francis Scott, Albert Sleiman Mellick
Summary: This review discusses chondroitin sulfate proteoglycan 4 (CSPG4) as a potential tumour biomarker and therapeutic target in squamous cell carcinoma (SCC). Lack of widely agreed upon diagnostic markers for SCCs is problematic, especially for patients who are aged, infirm, or have underlying conditions such as epidermolysis bullosa (EB). CSPG4, acting as a driver of tumourigenesis, regulates the turnover of extracellular matrix to promote tumour cell invasion, migration, inflammation and angiogenesis. The review analyzes the expression of CSPG4 in tissues and pathologies, and evaluates its usefulness as a diagnostic marker and therapeutic target for malignant SCC.
Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jie Yan, Litong Shi, Shan Lin, Yi Li
Summary: miR-624 targets ARRDC3 to inhibit its expression, consequently upregulating YAP expression and activating the HIF1 alpha signaling pathway, leading to increased chemoresistance in ESCC cells.
Article
Oncology
Lichun Sun, Kaixin Wang, Lu Peng, Jinfang Zhang, Jie Yang, Juan Zhao, Jiang Xu, Jun Zheng, Yan Zeng
Summary: This study revealed that Naa10p plays a role in enhancing cisplatin sensitivity in oral squamous cell carcinoma (OSCC) and may serve as a potential target for chemotherapy in OSCC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Wu Lin, Jiong Qian, Haohao Wang, Ling Ren, Yan Yang, Chuanzhi Chen, Xiangliu Chen, Yingying Huang, Jin Liu, Nong Xu, Lisong Teng
Summary: This study investigates the antitumor efficacy of cisplatin plus anti-PD-1 antibody in patients with advanced esophageal squamous cell carcinoma (ESCC). The results demonstrate enhanced antitumor effects and increased CD8(+) tumor-infiltrating lymphocytes with combination therapy. Clinical data analysis shows that cisplatin-based chemotherapy plus anti-PD-1 antibody is an effective and safe option for these patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Seungwon Lee, Jun-Young Park, Jaewon Park, Jian Cheng Bi, Byeongwoo Kang, Young Hyun Hwang, Jiwon Seok, Young Wook Park, Byeong-Kwon Ju
Summary: This study employs exciton diffusion guidance and energy extraction to enhance the optical efficiency and suppress the roll-off characteristics of mixed-host blue TADF OLEDs. The nanopixel array, created by a nanoscale pixel-defining layer (nPDL), separates excitons and polarons, increasing triplet quenching through secure exciton diffusion. Additionally, a corrugated metal cathode structure enables nonradiative energy transfer to surface plasmon polaritons, boosting emission efficiency. The optimized nPDL structure leads to significant improvements in external quantum efficiency, current efficiency, power efficiency, and critical luminance.
ADVANCED ELECTRONIC MATERIALS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Seong-Gon Kim
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, Research & Experimental
Yei-Jin Kang, Sang-Shin Lee, Seong-Gon Kim
Summary: A 75-year-old male patient presented with a 35-mm fluctuant lesion on the floor of the mouth. The lesion was a dome-shaped non-infiltrating angiolipoma, and it was successfully excised using an intraoral approach. This is the first reported case of this type of tumor being treated in this way in an elderly patient.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Seong-Gon Kim, Young-Wook Park, Ji-Hyeon Oh
Summary: This retrospective study analyzed the changes in condylar position following mandibular setback surgery with manual guidance. The results showed significant anterior-lateral-inferior movement of the condyle within 1 week after surgery, but the condyle returned to its original position over time.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Jwa-Young Kim, Yong-Chan Lee, Seong-Gon Kim, Umberto Garagiola
Summary: This comprehensive review explores the integration of 3D printing and Virtual Surgical Planning (VSP) in orthognathic and oral maxillofacial surgery, which enables personalized surgical methods, precise planning through tactile 3D models, and accurately designed surgical guides for improved patient-centric care and predictable outcomes.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Jwa-Young Kim, Seong-Gon Kim, Umberto Garagiola
Summary: The potential of sericin, a protein derived from silkworms, is explored for bone graft applications due to its biocompatibility, hydrophilic nature, and cost-effectiveness. It has antioxidant, anti-inflammatory, and UV-resistant properties that contribute to a healthier bone-healing environment, and its incorporation into 3D-printed grafts could lead to personalized medical solutions. However, gaps still exist in our understanding of sericin's mechanism of action, its long-term biocompatibility in humans, and the best methods for incorporating it into graft materials.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Min Keun Kim, Min Ji Ham, Won Rae Kim, Hyung Giun Kim, Kwang Jun Kwon, Seong Gon Kim, Young Wook Park
Summary: This study aimed to evaluate the accuracy of three-dimensional surgical guides and titanium implants in a rabbit model, as well as the surgical outcomes of mandibulectomy and reconstructive surgery. The accuracy of the implants was within the acceptable error range, while the surgical accuracy varied in different measured areas. The angle between the mandibular lower borders showed the most sensitive results, and the distance between the lingual cusps of the first molars represented the most accurate outcomes. The angle between the mandibular lower borders was found to be a good indicator for evaluating reconstructive surgery outcomes.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Seong-Gon Kim
Summary: This study evaluated the optimal scaffold material for silk sericin-based bone grafts using a critical-sized bone defect model in rat calvaria. The results showed that collagen exhibited better bone regeneration capability in silk sericin-based bone grafts compared to gelatin.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Yei-Jin Kang, Dae-Won Kim, Won-Geun Yang, Weon-Sik Chae, Seong-Gon Kim
Summary: The study demonstrates that pretreatment with 4-hexylresorcinol (4HR) increases the β-sheet structure of silk sericin, induces BMP-2 expression, and enhances bone regeneration ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yong-Chan Lee, Seong-Gon Kim
Summary: Orthognathic surgery has traditionally relied on traditional surgical planning, but the advent of virtual surgical planning (VSP) and 3D printing technologies has revolutionized the field, bringing unprecedented precision and customization. VSP allows for real-time adjustments and reduces planning time, while 3D printing enhances the predictability of surgical outcomes. The integration of VSP and 3D printing offers innovative solutions that surpass the limitations of traditional methods.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Dhouha Gaida, Young-Wook Park, Seong-Gon Kim
Summary: This study investigated the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, specifically in relation to diabetes-induced taste issues. The findings highlight the significant deterioration of taste buds in diabetic rats and suggest the potential therapeutic benefits of 4-HR in improving taste perception.
APPLIED SCIENCES-BASEL
(2023)
Meeting Abstract
Cell & Tissue Engineering
Seong-Gon Kim, Ji-Hyeon Oh, Yei-Jin Kang, HaeYong Kweon
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Seong-Gon Kim, Yei-Jin Kang, HaeYong Kweon, Ji-Hyeon Oh
TISSUE ENGINEERING PART A
(2022)
Article
Nanoscience & Nanotechnology
Cheol Shin, Seungwon Lee, Kwang Wook Choi, Young Hyun Hwang, Young Wook Park, Byeong-Kwon Ju
Summary: In this study, a nanoscale random rubbed structure (nRRS) was evaluated for its application as a scattering layer in OLEDs. The optimized nRRS, fabricated via rubbing, exhibited high transmittance and haze, making it suitable for OLEDs and improving their external quantum efficiency. The optical performance of the nRRS-OLED was predicted through simulation and verified by experimental results.
NANOMATERIALS AND NANOTECHNOLOGY
(2022)
